Maddela / Pabbati / Reddy Kondakindi Quorum Quenching

A Chemical Biological Approach for Microbial Biofilm Mitigation and Drug Development
1. Auflage 2023
ISBN: 978-1-83767-139-7
Verlag: Royal Society of Chemistry
Format: EPUB
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, Band Volume 22

Reihe: Chemical Biology

Antibiotic resistance is a global health concern. Strains of pathogenic microorganisms that have developed resistance to multiple antibiotics, such as MRSA, are extremely difficult to treat, and alternative methods for tackling pathogenic microorganisms are in demand. One potential target for new therapeutics is inhibition of quorum sensing: how microorganisms communicate and form biofilms in a density-dependent manner. Inhibiting this system via ‘quorum quenching’ (QQ) is a promising route to new pharmaceuticals and for controlling biofilm formation and growth. Quorum sensing also provides interesting possibilities in synthetic biology for producing novel products, biosensors, bioactive molecules, and so on.

This book covers the biology of quorum sensing and quenching, and potential sources of QQ enzymes and other inhibitors, as well as an overview of their mechanism and potential biotech applications. The book also covers the potential for new drug development from QQ, covering a range of related topics including protein engineering, imaging and computational studies, and integrated systems. This book is an ideal companion to researchers in chemical biology and medicinal chemistry, particularly those interested in biofilm formation, quorum sensing, novel antimicrobial development, synthetic biology and enzymology.

Autoren/Hrsg.

Maddela, Naga Raju

Pabbati, Ranjit

Reddy Kondakindi, Venkateswar

Weitere Mitwirkende

Weissman, Kira J

Fachgebiete

• Naturwissenschaften Chemie Organische Chemie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Naturwissenschaften Biowissenschaften Bakteriologie

Inhaltsverzeichnis

Chemical Formation of Biofilms in Drug Development;Anti-quorum Sensing Therapies' Issues and Limitations;Antipseudomonal Therapy and Quorum Quenching: A Prospective Mark;Trends in Quorum Sensing and Quorum Quenching;Natural QSIs for Biofilm Control in Pathogenic Bacteria;Plant-based Quorum Sensing Inhibitors for Biofilm Control in Drug Resistant Staphylococcus aureus;Antibiotic Resistance in Pathogens – A Global Concern;Antibiotic Resistance in Microorganisms – Current Status;Antibiotic Resistance in Aquatic Environmental Systems: Implications on Global Public Health;Role of Quorum Quenching in Pathogen Control in Aquaculture;Quorum Sensing: A New Target for Anti-infective Drug Therapy;Molecular Identification and Detection of Quorum Quenching Pathogenic Microorganisms;Isolation of Quorum Quenching Microorganisms and Screening Methods;Quorum Quenching in Anti-virulence Therapy;Quorum Quenching Applications in Plant Biotechnology;Integrated QQ with Nano-techniques – A Potent Antibacterial Therapy;Methods for Extenuating Biofilms Associated Drug Resistance by Micro and Nano-techno Effectiveness and Progress of Anti-BFS Therapy Stratagems and Proceeded Perspective by Micro-crystals and Nano-crystals