Lundblad / Macdonald Handbook of Biochemistry and Molecular Biology

5. Auflage 2018
ISBN: 978-1-315-31443-3
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 1017 Seiten

Edited by renowned protein scientist and bestselling author Roger L. Lundblad, with the assistance of Fiona M. Macdonald of CRC Press, this fifth edition of the Handbook of Biochemistry and Molecular Biology gathers a wealth of information not easily obtained, including information not found on the web.
Presented in an organized, concise, and simple-to-use format, this popular reference allows quick access to the most frequently used data. Covering a wide range of topics, from classical biochemistry to proteomics and genomics, it also details the properties of commonly used biochemicals, laboratory solvents, and reagents. An entirely new section on Chemical Biology and Drug Design gathers data on amino acid antagonists, click chemistry, plus glossaries for computational drug design and medicinal chemistry. Each table is exhaustively referenced, giving the user a quick entry point into the primary literature.
New tables for this edition:

Chromatographic methods and solvents

Protein spectroscopy

Partial volumes of amino acids

Matrix Metalloproteinases

Gene Editing

Click Chemistry

Autoren/Hrsg.

Lundblad, Roger L.

Macdonald, Fiona

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Biochemie (med.)
• Naturwissenschaften Biowissenschaften Molekularbiologie
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie Medizinische Biotechnologie

Inhaltsverzeichnis

SECTION I: AMINO ACIDS, PEPTIDES, AND PROTEINS
Properties of Amino Acids
Data on the Naturally Occurring Amino Acids
Coefficients of Solubility Equations of Certain Amino Acids in Water
Heat Capacities, Absolute Entropies, and Entropies of Formation of Amino Acids and Related Compounds
Heat of Combustion, Enthalpy, and Free Energy of Formation of Amino Acids and Related Compounds
Solubilities of Amino Acids in Water at Various Temperatures
Heats of Solution of Amino Acids in Aqueous Solution at 25°C
Free Energies of Solution and Standard Free Energy of Formation of Amino Acids in Aqueous Solution at 25°C
Far Ultraviolet Absorption Spectra of Amino Acids
UV Absorption Characteristics of N-Acetyl Methyl Esters of the Aromatic Amino Acids, Cystine, and of N-Acetylcysteine
Numerical Values of the Absorbances of the Aromatic Amino Acids in Acid, Neutral, and Alkaline Solutions
Hydrophobicities of Amino Acids and Proteins
Partial Volumes of Amino Acids
Deamidation of Asparagine
Michael Reactions of Proteins
Molecular Weights of Proteins and Some Other Materials Including Sedimentation, Diffusion, and Frictional Coefficients and Partial Specific Volumes
Molar Absorptivity and A1cm 1% Values for Proteins at Selected Wavelengths of the Ultraviolet and Visible Region
Temperature Coefficients of Apparent Partial Specific Volumes of Proteins Expressed in ml/g/deg (dV/dT)
Protein pK Values
Intrinsic Viscosity of Proteins
Infrared Spectra of Proteins
Volume Changes for Some Macromolecule Association Reactions
Assay of Solution Protein Concentration
Spectrophotometric Determination of Protein Concentration in the Short-Wavelength Ultraviolet
SECTION II: ENZYMES
Turnover of Enzymes in Tissues
Molecular Turnover of Cytochromes in Animals
Matrix Metalloproteinases
Proteases in the Interstitial Space
Enzymes in Synthetic OrganicChemistry
Therapeutic Enzymes
Protease Inhibitors and Protease Inhibitor Cocktails
SECTION III: LIPIDOMICS AND LIPIDOMES
Evolution of the Classification and Nomenclature of Lipids
A Brief Glossary for Lipidomics
A Comprehensive Classification System for Lipids
Properties of Fatty Acids and Their Methyl Esters
Densities, Specific Volumes, and Temperature Coefficients of Fatty Acids from C8 to C12
Composition and Properties of Common Oils and Fats
Spectral Properties of Fatty Acids
IR Active Bands of Phosphatidylethanolamines (PE)
Concentration of Some Fatty Acids in Human Blood, Blood Plasma or Blood Serum
Some Unusual Fatty Acid Structures
SECTION IV: VITAMINS AND COE NZYMES
Properties of Vitamins
Biological Characteristics of Vitamins
Vitamers
Vitamin Names Discarded
SECTION V: NUCLEIC ACIDS
Some Definitions for Nucleic Acids
UV Spectral Characteristics and Acidic Dissociation Constants of 280 Alkyl Bases, Nucleosides, and Nucleotides
Ultraviolet Absorbance of Oligonucleotides Containing 2'-O-Methylpentose Residues
Spectrophotometric Constants of Ribonucleotides
Purines, Pyrimidines, Nucleosides, and Nucleotides: Physical Constants and Spectral Properties
Chemical Modification of Nucleic Acids
Polymerase Chain Reaction
Gene Editing
SECTION VI: GLYCOSCIENCE
Nomenclature of Carbohydrates
Chemical Modification of Carbohydrates
Some Properties of Glycosaminoglycans
Sugar Mimetics
Intrinsic Viscosity of Polysaccharides
SECTION VII: CHEMICAL BIOLOGY AND DRUG DESIGN
Unnatural Amino Acids for Incorporation into Proteins
Structures and Symbols for Synthetic Amino Acids Incorporated into Synthetic Polypeptides
Properties of the a-Keto Acid Analogs of Amino Acids
a,ß-Unsaturated Amino Acids
Amino Acid Antagonists
Particle Diameter
Weights of Cells and Cell Constituents
Click Chemistry
A Listing of Log P Values, Water Solubility, and Molecular Weight for Some Selected Chemicals
SECTION VIII: PHYSICAL AND CHEMICAL DATA
IUBMB-IUPAC Joint Commission on Biochemical Nomenclature (JCBN) Recommendations for Nomenclature and Tables in Biochemical Thermodynamics
Standard Transformed Gibbs Energies of Formation for Biochemical Reactants
Enthalpy, Entropy, and Free Energy Values for Biochemical Redox Reactions
Oxidation-Reduction Pot

Über Autor(innen)

Roger L. Lundblad, Ph.D.
Roger L. Lundblad is a native of San Francisco, California. He received his undergraduate education at Pacific Lutheran University and his PhD degree in biochemistry at the University of Washington. After postdoctoral work in the laboratories of Stanford Moore and William Stein at the Rockefeller University, he joined the faculty of the University of North Carolina at Chapel Hill. He joined the Hyland Division of Baxter Healthcare in 1990. Currently Dr. Lundblad is an independent consultant and writer in biotechnology in Chapel Hill, North Carolina. He is an adjunct Professor of Pathology at the University of North Carolina at Chapel Hill and Editor-in-Chief of the Internet Journal of Genomics and Proteomics.
Fiona M. Macdonald, Ph.D., F.R.S.C.
Fiona M. Macdonald received her BSc in chemistry from Durham University, UK. She obtained her PhD in inorganic biochemistry at Birkbeck College, University of London, studying under Peter Sadler. Having spent most of her career in scientific publishing, she is now at Taylor and Francis and is involved in developing chemical information products.