Llop / Gomez-Vallejo Isotopes in Nanoparticles

Fundamentals and Applications
Erscheinungsjahr 2016
ISBN: 978-981-4669-09-2
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 544 Seiten

The field of nanotechnology has attracted ever-increasing interest over the last few decades. There is currently large-scale incorporation of NPs into many industrial and commercial products, and multi-decorated particles are continuously being evaluated as potential biomedical agents. One of the main challenges to the biological evaluation of NPs (both in vitro and especially in vivo) is the difficulty associated with their tracking. Isotopic labelling, and especially radiolabelling, is a very useful and powerful strategy to determine non-invasively the biodistribution and biological fate of NPs in vivo after administration or involuntary incorporation into living organisms.

This book starts with an introduction to the different types of nanomaterials most commonly used in both the biomedical and industrial areas. It then compiles and discusses the various methods reported to date for the radiolabelling of nanomaterials with imaging purposes, and provides illustrative examples of potential applications of the labelled species. Finally, the use of nanomaterials in radiotherapy, stable isotopic labeling strategies, and operational health and safety aspects related with the manipulation of NPs in radioactive facilities are discussed. This book will appeal to anyone involved in nanotechnology, molecular imaging, radiochemistry, and nanomedicine.

Autoren/Hrsg.

Llop, Jordi

Gomez-Vallejo, Vanessa

Fachgebiete

• Technische Wissenschaften Maschinenbau | Werkstoffkunde Technische Mechanik | Werkstoffkunde
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Bildgebende Verfahren, Nuklearmedizin, Strahlentherapie Radiologie, Bildgebende Verfahren
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizintechnik, Biomedizintechnik, Medizinische Werkstoffe
• Technische Wissenschaften Sonstige Technologien | Angewandte Technik Medizintechnik, Biomedizintechnik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Bildgebende Verfahren, Nuklearmedizin, Strahlentherapie Nuklearmedizin, PET, Radiotherapie

Inhaltsverzeichnis

Introduction; S. E. Moya

Inorganic Nanoparticles; R. F. Ziolo

Oxide and Bioceramic Nanoparticles; V. Corral-Flores

Graphene, Carbon Nanotubes, and BCN Nanostructures; R. F. Ziolo

Polymeric Nanoparticles: Description, Synthesis, and Applications; Mauro Comes-Franchini

A Brief Overview of Radioactivity; Vanessa Gómez-Vallejo

In vivo Evaluation of Nanoparticle Pharmacokinetics by Molecular Imaging: Technical Aspects; Juan D. Gispert

Radiolabelling of NPs Using Radiometals: 99mTc, 68Ga, 67Ga, 89Zr, and 64Cu; Isabel García Radiolabelling of Nanoparticles Using Radiohalogens, 13N, and 11C; Jordi Llop

Radiolabelling of liposomes; Peter Laverman

Direct Ion-Beam Activation of Nanoparticles; Neil Gibson

Neutron Activation of Nanoparticles; Giulio Cotogno

7-Beryllium-Recoil Labelling of Nanoparticles; Uwe Holzwarth

Calculation Tools for Isotope Production by Beam Activation; Pedro Arce

Synthesis and Applications of Alpha/Beta Emitter-Labelled Nanoparticles; Adina Elena Stanciu

Radiochemical Stability Studies of Radiolabelled Nanoparticles; Jordi Llop

Labelling Nanoparticles with Non-radioactive Isotopes; Agnieszka Dybowska

Health and Safety Considerations for Radiolabelled Nanoparticles; Torsten Reese