Litwack Vitamins and Hormones

1. Auflage 2001
ISBN: 978-0-08-052284-5
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band Volume 62, 289 Seiten, Web PDF

Reihe: Vitamins and Hormones

Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board reflects expertise in the fields of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Every volume contains comprehensive reviews by leading contributors.

Autoren/Hrsg.

Litwack, Gerald

Inhaltsverzeichnis

1;Cover;1
2;Contents;8
3;Preface;12
4;Chapter 1. Green Tea: Biochemical and Biological Basis for Health Benefits;14
4.1;I. Introduction;15
4.2;II. Catechins and Other Constituents of Green Tea;17
4.3;III. Structure, Pharmacology, and Metabolism of Catechins;18
4.4;IV. Chemical and Biochemical Properties of Catechins;22
4.5;V. Biological Activity of Green Tea Catechins;27
4.6;VI. Molecular and Cellular Bases for Biological Effects of Catechins;65
4.7;VII. Epilog ;82
4.8;References;84
5;Chapter 2. Proteins Regulating the Biosynthesis and Inactivation of Neuromodulatory Fatty Acid Amides;108
5.1;I. Fatty Acid Amides as Endogenous Signaling Molecules;108
5.2;II. The Biosynthesis of Fatty Acid Amides;111
5.3;III. The Enzymatic Inactivation of Fatty Acid Amides;117
5.4;IV. Transport of Fatty Acid Amides;129
5.5;V. Conclusions and Future Challenges;134
5.6;References;136
6;Chapter 3. Three-Dimensional Organization of the Aquaporin Water Channel: What Can Structure Tell Us about Function?;146
6.1;I. Movement of Water across the Membrane„Discovery of Aquaporin-1;146
6.2;II. Mammalian Aquaporins and Their Transport Function;147
6.3;III. Investigations of Amino Acid Residues Involved in Solute Transport in Aquaporins;150
6.4;IV. Structural Studies of Aquaporins;151
6.5;V. Unresolved Questions and Future Directions;171
6.6;References;173
7;Chapter 4. Cytostatic p21 G Protein-Activated Protein Kinase .-PAK;180
7.1;I. Background;181
7.2;II. Comparison of PAK Proteins;183
7.3;III. Autophosphorylation and Activation of .-PAK;186
7.4;IV. .-PAK Has Cytostatic Activity;187
7.5;V. Activation of .-PAK in Response to Stress ;190
7.6;VI. The Individual Roles of .-PAK and SAPK/p38 in the Stress Response ;198
7.7;VII. Substrates for .-PAK;199
7.8;VIII. Working Model—A Role for .-PAK as a Master Switch;202
7.9;IX. Conclusions and Remaining Questions;204
7.10;References;205
8;Chapter 5. Androgen Receptors and Their Biology;212
8.1;I. Mechanism of Androgen Action;212
8.2;II. Sexual Development;217
8.3;III. Androgen Receptors and Disease;220
8.4;IV. Androgen Action and Other Diseases;226
8.5;V. Conclusion;232
8.6;References;232
9;Chapter 6. Transcriptional Activation of Genes by 17ß-Estradiol through Estrogen Receptor–Sp1 Interactions;244
9.1;I. Introduction;245
9.2;II. Transcriptional Activation through Sp1(N)xERE 1/2 and Sp1(N)xERE Motifs;247
9.3;III. Transcriptional Activation by E2 through GC-Rich Sites;250
9.4;IV. E2-Responsive Genes with Functional GC-Rich Promoter Elements;252
9.5;V. ERa/Sp1 Activation by Growth Factors;255
9.6;VI. ERa/Sp1 vs ERß/Sp1 Action and Effects of Ligand Structure and Cell Context;256
9.7;VII. Summary;257
9.8;References;258
10;Chapter 7. Drug Discovery and the Intracellular Receptor Family;266
10.1;I. The History of Intracellular Receptor Ligands as Drugs;267
10.2;II. Diseases in Which Intracellular Receptors Play a Role;267
10.3;III. Intracellular Receptor Ligands with Therapeutic Utility (Agonists and Antagonists);268
10.4;IV. Partial Agonists of Intracellular Receptors;270
10.5;V. Ligand Discovery;273
10.6;VI. Direct Measures of Intracellular Receptor Conformation;279
10.7;VII. Indirect Methods of Conformation Determination;280
10.8;VIII. Cofactor–Receptor Interactions;281
10.9;IX. Assays Used to Measure the Function of the Ligand–Receptor Complex ;283
10.10;X. The in Vitro–in Vivo Connection;285
10.11;XI. Conclusion;287
10.12;References;287
11;Index;294