Litwack Vitamins and Hormones

1. Auflage 2003
ISBN: 978-0-08-049243-8
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band Volume 66, 611 Seiten, Web PDF

Reihe: Vitamins and Hormones

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the Serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines. - First published in 1943, Vitamins and Hormones is AP's longest running serial - Each volume contains cutting edge reviews by leading contributors

Autoren/Hrsg.

Litwack, Gerald

Inhaltsverzeichnis

1;Cover;1
2;Copyright Page;5
3;Contents;8
4;Contributors;16
5;Preface;20
6;Chapter 1. Molecular Biology of Hematopoietic Stem Cells;22
6.1;I. Introduction;23
6.2;II. Immunological and Functional Characteristics;24
6.3;III. Cell Cycle and Differentiation Control;27
6.4;IV. Adhesion Molecules in Hematopoiesis and Stem Cell Trafficking;31
6.5;V. Aging and Telomeres;34
6.6;VI. Trandifferentiation and Developmental Plasticity;38
6.7;VII. Conclusions;40
6.8;References;40
7;Chapter 2. Aldosterone: Its Receptor, Target Genes, and Actions;50
7.1;I. Introduction;51
7.2;II. Physiological Actions of Aldosterone;53
7.3;III. Molecular Basis of Mineralocorticoid Action;58
7.4;IV. Aldosterone Action in Epithelia: Afforded by 11B-Hydroxysteroid Dehydrogenase 2;63
7.5;V. Genetic Mouse Models in the Investigation of Aldosterone Action;67
7.6;VI. Aldosterone Target Genes That Mediate Physiological Responses;69
7.7;VII. Controversies with Aldosterone;78
7.8;VIII. Concluding Remarks;82
7.9;References;83
8;Chapter 3. Corticosteroid Receptors, 11B-Hydroxysteroid Dehydrogenase, and the Heart;98
8.1;I. Introduction;100
8.2;II. Corticosteroid Hormones;100
8.3;III. Corticosteroid Receptors;101
8.4;IV. Mechanism of Action of Corticosteroid Receptor;105
8.5;V. Modulators of Corticosteroid Signaling;108
8.6;VI. Heart;112
8.7;VII. Summary;122
8.8;References;123
9;Chapter 4. Forms of Mineralocorticoid Hypertension;134
9.1;I. Introduction;135
9.2;II. Evolution, Salt, and the Renin-Angiotensin-Aldosterone System;136
9.3;III. Key Elements of Mineralocorticoid Activity;138
9.4;IV. Mineralocorticoid Hypertension;145
9.5;V. Primary Aldosteronism;146
9.6;VI. Genetic Forms of Mineralocorticoid Hypertension;156
9.7;VII. Aldosterone–Dependent Essential Hypertension;163
9.8;References;164
10;Chapter 5. Peroxisome Proliferator-Activated Receptors and the Cardiovascular System;178
10.1;I. Introduction;179
10.2;II. Discovery, Structure, and Tissue Distribution of PPARs,;180
10.3;III. PPARs Ligands;181
10.4;IV. Mechanisms of Action of PPARs;183
10.5;V. PPARy in the Cardiovascular System;184
10.6;VI. PPARa in the Cardiovascular System;191
10.7;VII. PPARd in the Cardiovascular System;194
10.8;VIII. Conclusions;196
10.9;References;197
11;Chapter 6. Serotonin and the Neuroendocrine Regulation of the Hypothalamic-Pituitary- Adrenal Axis in Health and Disease;210
11.1;I. Overview of Serotonin;211
11.2;II. Neuroanatomy of the Hypothalamic-Pituitary-Adrenal Axis;216
11.3;III. Serotonin and the Hypothalamic-Pituitary-Adrenal Axis;224
11.4;IV. Physiological Interactions ;233
11.5;V. Pathophysiological Interactions;241
11.6;VI. Concluding Remarks;249
11.7;References;250
12;Chapter 7. The Thymosins: Prothymosin a, Parathymosin, and B-Thymosin: Structure and Function;278
12.1;I. Introduction;279
12.2;II. Polypeptide B1;280
12.3;III. a-Thymosins and Prothymosin a;281
12.4;IV. Parathymosin;291
12.5;V. B -Thymosins;294
12.6;VI. Conclusions;305
12.7;References;306
13;Chapter 8. Thymosin B4 Interactions;318
13.1;I. B-Thymosin Structure;319
13.2;II. Thymosin B4 and the Actin Cytoskeleton;320
13.3;III. Assays for Thymosin B4-Actin Interactions;327
13.4;IV. Ternary Complexes;330
13.5;V. Thymosin B4 Ligands in Immunity and Inflammation;333
14;Chapter 9. Polypeptide Hormones: Signaling Molecules in Plants;338
14.1;I. Introduction;339
14.2;II. Systemin and Systemin-like Peptides;339
14.3;III. Rapid Alkalinization Factor (RALF);342
14.4;IV. ENOD40 and Root Nodulation;343
14.5;V. CLAVATA3 and Meristem Organization;345
14.6;VI. Phytosulfokines;348
14.7;VII. Brassica Self-Incompatibility;351
14.8;VIII. Polaris (PLS);355
14.9;IX. Conclusion;358
14.10;References;358
15;Chapter 10. Parathyroid Hormone-Related Protein (PTHrP): A Nucleocytoplasmic Shuttling Protein with Distinct Paracrine and Intracrine Roles;366
15.1;I. Introduction;367
15.2;II. Paracrine and Intracrine Actions of PTHrP;368
15.3;III. The Nuclear Import Mechanism of PTHrP;377
15.4;IV. Nuclear Transport of Polypeptide Ligands;389
15.5;V. Nuclear Export Pathway of PTHrP;391
15.6;VI. Functional Role of PTHrP in the Nucleus/Nucleolus;393
15.7;VII. Future Prospects;395
15.8;References;396
16;Chapter 11. Nerve Growth Factor-Dependent Regulation of Nade-Induced Apoptosis;406
16.1;I. Background;407
16.2;II. Structural Features of NADE;410
16.3;III. NADE Isoforms;411
16.4;IV. Genomic Structure of NADE Genes;412
16.5;V. Expression of NADE;413
16.6;VI. Association of NADE with P75NTR;414
16.7;VII. 14-3-3 Protein Interacts with NADE;416
16.8;VIII. NADE Is Involved in NGF-Induces Apoptosis via P75NTR;416
16.9;IX. Future Directions;419
16.10;References;420
17;Chapter 12. Membrane Transport of Folates;424
17.1;I. Introduction;426
17.2;II. Reduced Folate Carrier (RFC), a Member of the SLC19 Family of Transporters;426
17.3;III. Transport of Folates by SLC21 Organic Anion Carriers;448
17.4;IV. Folate Transporters That Operate Optimally at Low pH: The Mechanism of Folate Transport in Intestinal Cells;449
17.5;V. The Family of Folate Receptors (FRs);451
17.6;VI. Multidrug Resistance-Associated Proteins (MRPs) and Their Impact on the Transport of Folates;455
17.7;VII. Transport of Folates by Other ABC Exporters;457
17.8;VIII. Factors That Influence Concentrative Folate Transport in Cells;458
17.9;IX. The Localization of Folate Transport in Epithelia;460
17.10;X. The Role if Folate Transporters in Mouse Development;462
17.11;References;462
18;Chapter 13. Vitamin A and Infancy: Biochemical, Functional, and Clinical Aspects;478
18.1;I. A Premise;479
18.2;II. Vitamin A: Intestinal Digestion, Absorption, and Tissue Delivery;480
18.3;III. Intracellular Metabolism;485
18.4;IV. Retinol and Embryogenesis: Mechanism of Action and Importance;491
18.5;V. Retinol and Infancy;520
18.6;VI. Altered Vitamin A Levels and Childhood Pathologies;530
18.7;VII. Few Final Considerations;556
18.8;References;557
19;Index;614