Li / Zhang / Tse Handbook of LC-MS Bioanalysis

Best Practices, Experimental Protocols, and Regulations
1. Auflage 2013
ISBN: 978-1-118-67134-4
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 704 Seiten, E-Book

Consolidates the information LC-MS bioanalytical scientistsneed to analyze small molecules and macromolecules
The field of bioanalysis has advanced rapidly, propelled by newapproaches for developing bioanalytical methods, new liquidchromatographic (LC) techniques, and new mass spectrometric (MS)instruments. Moreover, there are a host of guidelines andregulations designed to ensure the quality of bioanalyticalresults.
Presenting the best practices, experimental protocols, and thelatest understanding of regulations, this book offers acomprehensive review of LC-MS bioanalysis of small molecules andmacromolecules. It not only addresses the needs of bioanalyticalscientists working on routine projects, but also explores advancedand emerging technologies such as high-resolution mass spectrometryand dried blood spot microsampling.
Handbook of LC-MS Bioanalysis features contributions froman international team of leading bioanalytical scientists. Theircontributions reflect a review of the latest findings, practices,and regulations as well as their own firsthand analyticallaboratory experience. The book thoroughly examines:
* Fundamentals of LC-MS bioanalysis in drug discovery, drugdevelopment, and therapeutic drug monitoring
* The current understanding of regulations governing LC-MSbioanalysis
* Best practices and detailed technical instructions for LC-MSbioanalysis method development, validation, and stabilityassessment of analyte(s) of interest
* Experimental guidelines and protocols for quantitative LC-MSbioanalysis of challenging molecules, including pro-drugs, acylglucuronides, N-oxides, reactive compounds, and photosensitive andautooxidative compounds
With its focus on current bioanalytical practice, Handbook ofLC-MS Bioanalysis enables bioanalytical scientists to developand validate robust LC-MS assay methods, all in compliance withcurrent regulations and standards.

Autoren/Hrsg.

Li, Wenkui

Zhang, Jie

Tse, Francis L. S.

Über Autor(innen)

WENKUI LI, PhD, is Senior Fellow in the Department ofDrug Metabolism & Pharmacokinetics at Novartis Institutes forBioMedical Research, where he focuses on regulated LC-MS/MSbioanalysis for the toxicokinetic and pharmacokinetic assessment ofdrug candidates. Dr. Li is a member of the editorial board ofBiomedical Chromatography.
JIE ZHANG, PhD, is Senior Fellow in the Department ofDrug Metabolism & Pharmacokinetics at Novartis Institutes forBioMedical Research, where he focuses on regulated LC-MSbioanalysis for the toxicokinetic and pharmacokinetic assessment ofdrug candidates. In addition, Dr. Zhang evaluates and implementsnovel technologies and processes in regulated LC-MSbioanalysis.
FRANCIS L. S. TSE, PhD, is Vice President of DrugMetabolism & Bioanalytics at Novartis Institutes for BioMedicalResearch, overseeing the unit's strategy and operations in NorthAmerica and Asia. Dr. Tse is a Fellow of the American Associationof Pharmaceutical Scientists, APhA Academy of PharmaceuticalResearch and Science, and American College of ClinicalPharmacology.