Li / Tian Drug Delivery Applications of Noninvasive Imaging

Validation from Biodistribution to Sites of Action
1. Auflage 2013
ISBN: 978-1-118-35682-1
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 478 Seiten, E-Book

Cost-effective strategies for designing novel drug deliverysystems that target a broad range of disease conditions
In vivo imaging has become an important tool for thedevelopment of new drug delivery systems, shedding new light on thepharmacokinetics, biodistribution, bioavailability, localconcentration, and clearance of drug substances for the treatmentof human disease, most notably cancer. Written by a team ofinternational experts, this book examines the use of quantitativeimaging techniques in designing and evaluating novel drug deliverysystems and applications.
Drug Delivery Applications of Noninvasive Imaging offersa full arsenal of tested and proven methods, practices andguidance, enabling readers to overcome the many challenges increating successful new drug delivery systems. The book begins withan introduction to molecular imaging. Next, it covers:
* In vivo imaging techniques and quantitativeanalysis
* Imaging drugs and drug carriers at the site of action,including low-molecular weight radiopharmaceuticals, peptides andproteins, siRNA, cells, and nanoparticles
* Applications of imaging techniques in administration routesother than intravenous injection, such as pulmonary and oraldelivery
* Translational research leading to clinical applications
* Imaging drug delivery in large animal models
* Clinical applications of imaging techniques to guide drugdevelopment and drug delivery
Chapters are based on a thorough review of the currentliterature as well as the authors' firsthand experience workingwith imaging techniques for the development of novel drug deliverysystems.
Presenting state-of-the-technology applications of imaging inpreclinical and clinical evaluation of drug delivery systems,Drug Delivery Applications of Noninvasive Imaging offerscost-effective strategies to pharmaceutical researchers andstudents for developing drug delivery systems that accuratelytarget a broad range of disease conditions.

Autoren/Hrsg.

Li, Chun

Tian, Mei

Inhaltsverzeichnis

Preface ix
contributors xi
1 Introduction to Molecular Imaging 1
Vikas Kundra
2 PET/SPECT: Instrumentation and Imaging Techniques 12
Yuan-Chuan Tai
3 Photoacoustic Tomography and Its Applications in Drug Deliveryand Photothermal Therapy 45
Liang Song and Lihong V. Wang
4 Raman Microspectral Imaging for Label-Free Detection ofNanoparticle-Mediated Cellular and Subcellular Drug Delivery70
Tatyana Chernenko, Lara Milane, Christian Matthäus, MaxDiem, and Mansoor Amiji
5 A natomical and Functional MRI91
Edward F. Jackson
6 Quantitative Imaging in Drug Delivery 125
Kooresh I. Shoghi
7 PET Imaging of the Pharmacokinetics of Small Molecular-WeightDrugs 147
Stephen M. Moerlein and Zhude Tu
8 Imaging Peptides, Proteins, and Antibody Delivery 192
Frederik L. Giesel and Clemens Kratochwil
9 In Vivo Imaging and Delivery of siRNA199
Zdravka Medarova and Anna Moore
10 Imaging Cell Therapy 223
Yajie Liang and Jeff W. M. Bulte
11 Radiolabeled Liposomes as Drug Delivery Nanotheranostics252
William T. Phillips, Ande Bao, Keitaro Sou, Shihong Li, and BethGoins
12 Polymeric Micelles as Imaging Agents and Drug DeliverySystems 268
Jun Zhao and Chun Li
13 Perfluorocarbon Nanoparticles: Translating BenchOpportunities to the Clinic 296
G. M. Lanza, P. M. Winter, S. D. Caruthers, A. H. Schmieder, andS. A. Wickline
14 Cancer Theranostics with Hollow Gold Nanospheres 308
Wei Lu and Chun Li
15 Imaging Pulmonary Drug Delivery 333
Stephen P. Newman
16 In Vivo Imaging for Validation of Oral Dose Performance367
Fiona J. McInnes and Howard N. E. Stevens
17 Role of Large Animal Models in Translational Studies ofImaging and Targeted Drug Delivery 389
Rajesh K. Uthamanthil and Mei Tian
18 Imaging Transcatheter Delivery to Liver Tumors 412
Adil Al-Nahhas, Meeran Naji, and Imene Zerizer
19 Direct Visualization of Therapeutic Radionuclide DistributionUsing Nuclear Medicine Imaging: I-131 in Metastatic ThyroidCarcinoma 426
Ho Young Lee, June-Key Chung, So Won Oh, Jong Jin Lee, Keon WookKang, Do Joon Park, Bo Youn Cho, and Myung Chul Lee
20 Imaging Drug Delivery to the CNS Using Translational PositronEmission Tomography Studies 432
Chi-Ming Lee, Katarina Varnäs, and Lars Farde
Index 449

Über Autor(innen)

CHUN LI, PhD, is Professor and Ad Interim Chief,Chemistry Section, in the Department of Cancer Systems Imaging atthe University of Texas MD Anderson Cancer Center. He is AssociateEditor of Cancer Nanotechnology and a member of theeditorial boards of American Journal of Nuclear Medicine andMolecular Imaging and Quantitative Imaging in Medicine andSurgery. Dr. Li has more than 120 peer-reviewed publicationsand holds twenty-eight patents.
MEI TIAN, MD, is Vice President of Hangzhou BinjiangHospital and Professor of Diagnostic Imaging and Nuclear Medicineat The Second Hospital, Zhejiang University School of Medicine. Dr.Tian is also an editorial consultant for The Lancet. She isa member of the editorial boards of Journal of Nuclear Medicine,European Journal of Nuclear Medicine and Molecular Imaging, NuclearMedicine Communications, and Oncology.