Labouesse Forces and Tension in Development

1. Auflage 2011
ISBN: 978-0-12-385066-9
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band Volume 95, 328 Seiten, Web PDF

Reihe: Current Topics in Developmental Biology

This book presents some of the most advanced experimental systems in which the role of forces has been dissected. It explores the physical principles accounting for how forces can affect soft matter such as our cells, and presents some of the methods used to measure or assess the role of forces. - Presents some of the most advanced experimental systems in which the role of forces has been dissected - Explores the physical principles accounting for how forces can affect soft matter such as our cells, and presents some of the methods used to measure or assess the role of forces - Appeals to both physicists eager to get familiar with biological systems and to biologists curious about the physical principles behind what they observe

Autoren/Hrsg.

Labouesse, Michel

Inhaltsverzeichnis

1;Front Cover;1
2;Forces and Tension in Development;4
3;Copyright;5
4;Contents;6
5;Contributors;10
6;Preface;12
6.1;Microtubule-Generated Flows;14
6.2;Actomyosin-Based and Adhesion-Based Forces;14
6.3;Additional Foreword to Physicists;15
6.4;References;16
7;Chapter 1: Experimental Evidence for the Geometric Clutch Hypothesis;18
7.1;1. Introduction;19
7.2;2. Experimental Support;26
7.3;3. The Underlying Assumptions;29
7.4;4. Support for the Four Basic Assumptions;29
7.5;5. Discussion;39
7.6;Acknowledgments;44
7.7;References;44
8;Chapter 2: From Cilia Hydrodynamics to Zebrafish Embryonic Development;50
8.1;1. Introduction;51
8.2;2. Motile Cilia and Zebrafish Development;52
8.3;3. Structure of Motile Cilia in the Developing Zebrafish;55
8.4;4. The Physics Side of Cilia-Mediated Flow: From Modeling to Experiment;58
8.5;5. Experimental Investigation of Cilia-Driven Fluid Flow in Developing Embryos;68
8.6;6. Role of Cilia-Driven Flow in the Kupffer's Vesicle in Zebrafish;74
8.7;7. Role of Cilia-Driven Flow in the Developing Inner Ear in Zebrafish;75
8.8;8. Conclusion;78
8.9;Acknowledgments;79
8.10;References;79
9;Chapter 3: Spontaneous Mechanical Oscillations...;84
9.1;1. Introduction;85
9.2;2. Part I: Molecular Motors and Oscillations;86
9.3;3. Part II: Oscillations Related to Myosin Motors in Cells and in Embryos;93
9.4;4. Conclusions;102
9.5;Acknowledgments;104
9.6;References;104
10;Chapter 4: Cortical Forces in Cell Shape Changes and Tissue Morphogenesis;110
10.1;1. Introduction;111
10.2;2. Molecular Origins of Cortical Forces;112
10.3;3. Cortical Forces Controlling Cell Shapes During Tissue Morphogenesis;118
10.4;4. Dynamic Spatiotemporal Distribution of Cortical Forces and Cell Shape Changes;128
10.5;5. Methods;138
10.6;6. Concluding Remarks;154
10.7;Acknowledgments;154
10.8;References;154
11;Chapter 5: Tension and Epithelial Morphogenesis in Drosophila Early Embryos;162
11.1;1. Introduction;163
11.2;2. Anatomy and Cell Biology of the Early Embryo: An Overview;164
11.3;3. Cell-Autonomous Behaviors and Intrinsic Forces in the Gastrulating Embryo;171
11.4;4. Passive Cell Behaviors and Extrinsic Forces in the Gastrulating Drosophila Embryo;180
11.5;5. Tension and Supracellular Actomyosin Structures in the Early Embryo;187
11.6;6. Final Remarks;195
11.7;Acknowledgments;197
11.8;References;197
12;Chapter 6: Cell Sorting in Development;206
12.1;1. Introduction;207
12.2;2. Principles of Cell Sorting;207
12.3;3. Measuring Tissue Surface Tension (TST);210
12.4;4. Cell Sorting in Development;214
12.5;5. Outlook;224
12.6;References;225
13;Chapter 7: Embryo Mechanics...;232
13.1;1. Introduction;233
13.2;2. Mechanics of Development;234
13.3;3. Morphology and Kinematics: The Foundations of a Biomechanical Analysis;237
13.4;4. Materials and Structures Responsible for the Mechanical Resistance of Embryonic Tissues;243
13.5;5. Approaches for Measuring Stress and Force Production;249
13.6;6. Mechanical Hypothesis Building from Histology and Compositional Analysis;250
13.7;7. Challenges in Integrative Biomechanics: From Molecular to Whole Organism;251
13.8;8. Discussion and Conclusion: Biomechanical Variability, Robustness, and the Origin of Birth Defects;254
13.9;Acknowledgments;255
13.10;References;255
14;Chapter 8: Mechanotransduction in Development;260
14.1;1. Introduction;261
14.2;2. Mechanotransduction in Cultured Cells;262
14.3;3. Mechanotransduction in Embryonic Development;265
14.4;4. Perspectives in Evolution and Cancer;276
14.5;Acknowledgments;277
14.6;References;277
15;Index;284
16;Contents of Previous Volumes;292
17;Colour Plate;328