Kresina An Introduction to Molecular Medicine and Gene Therapy

1. Auflage 2004
ISBN: 978-0-471-46104-3
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 416 Seiten, E-Book

Gene therapy, or the use of genetic manipulation for diseasetreatment, is derived from advances in genetics, molecular biology,clinical medicine, and human genomics. Molecular medicine, theapplication of molecular biological techniques to disease treatmentand diagnosis, is derived from the development of human organtransplantation, pharmacotherapy, and elucidation of the humangenome. An Introduction to Molecular Medicine and GeneTherapy provides a basis for interpreting new clinical andbasic research findings in the areas of cloning, gene transfer, andtargeting; the applications of genetic medicine to clinicalconditions; ethics and governmental regulations; and the burgeoningfields of genomics, biotechnology, and bioinformatics. By dividingthe material into three sections - an introduction to basicscience, a review of clinical applications, and a discussion of theevolving issues related to gene therapy and molecular medicine-thiscomprehensive manual describes the basic approaches to the broadrange of actual and potential genetic-based therapies.
In addition, An Introduction to Molecular Medicine andGene Therapy:
* Covers new frontiers in gene therapy, animal models, vectors,gene targeting, and ethical/legal considerations
* Provides organ-based reviews of current studies in gene therapyfor monogenetic, multifactoral or polygenic disorders, andinfectious diseases
* Includes bold-faced terms, key concepts, summaries, and listsof helpful references by subject in each chapter
* Contains appendices on commercial implications and a review ofthe history of gene therapy
This textbook offers a clear, concise writing style, drawingupon the expertise of the authors, all renowned researchers intheir respective specialties of molecular medicine. Researchers ingenetics and molecular medicine will all find An Introductionto Molecular Medicine and Gene Therapy to be an essentialguide to the rapidly evolving field of gene therapy and itsapplications in molecular medicine.

Autoren/Hrsg.

Kresina, Thomas F.

Inhaltsverzeichnis

Molecular Medicine and Gene Therapy: An Introduction (T. Kresina& A. Branch).
Nuclear Transplantation and New Frontiers in Genetic MolecularMedicine (D. Jerry, et al.).
Building a Better Mouse: Genetically Altered Mice as Models forGene Therapy (E. Sandgren & W. Kisseberth).
Vectors in Gene Therapy (K. Ponder).
Gene Targeting (E. Kmiec).
Gene Therapy of Hematological Disorders (C. Dunbar & T.Wu).
Gene Therapy for Liver Disease (C. Schilling, et al.).
Gene Therapy in Cardiovascular Disease (V. Dzau, et al.).
Components of Cell and Gene Therapy for Neurological Disorders (L.Doering).
Gene Therapy in the Treatment of Cancer (S. Hall, et al.).
Gene Therapy for HIV Infection (B. Bunnell).
Gene Therapy Approaches for Rheumatoid Arthritis (R. Gay, etal.).
Federal Oversight of Gene Therapy Research (T. Kresina).
Ethical Issues in Molecular Medicine and Gene Therapy (L.Fleck).
Epilogue: Personal Genetic Medicine-The Future Is Now (T.Kresina).
Appendix.
Index.