Krauss / Welschof | Recombinant Antibodies for Cancer Therapy | Buch | 978-1-61737-250-6 | sack.de

Buch, Englisch, Band 207, 481 Seiten, Previously published in hardcover, Format (B × H): 155 mm x 235 mm, Gewicht: 744 g

Reihe: Methods in Molecular Biology

Krauss / Welschof

Recombinant Antibodies for Cancer Therapy

Methods and Protocols
1. Auflage. Softcover version of original hardcover Auflage 2003
ISBN: 978-1-61737-250-6
Verlag: Humana Press

Methods and Protocols

Buch, Englisch, Band 207, 481 Seiten, Previously published in hardcover, Format (B × H): 155 mm x 235 mm, Gewicht: 744 g

Reihe: Methods in Molecular Biology

ISBN: 978-1-61737-250-6
Verlag: Humana Press


In Recombinant Antibodies for Cancer Therapy: Methods and Protocols, Martin Welschoff and Jürgen Krauss present a collection of carefully selected protocols for the design, construction, and characterization of novel anticancer therapeutics based on recombinant antibody technology. These readily reproducible methods include coverage of hybridoma-derived recombinant antibodies, recombinant antibody fragments from phagemid-displayed antibody repertoires, antibody fragments with additional properties, and large-scale production of recombinant antibodies for clinical applications. Concise review articles also survey the current status of recombinant antibodies in cancer therapy, as well as the generation of antibody molecules through antibody engineering.

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Zielgruppe


Research

Weitere Infos & Material


Part I. Introduction

Generation of Antibody Molecules Through Antibody Engineering
Sergey M. Kipriyanov

Application of Recombinant Antibodies in Cancer Patients
Jürgen Krauss, Michaela Arndt, and Michael Pfreundschuh

Part II. Hybridoma-Derived Antibodies

DNA Immunization as a Means to Generate Antibodies to Proteins
Partha S. Chowdhury

Chimerization of a Monoclonal Antibody for Treating Hodgkin's Lymphoma
Jürgen Krauss, Hans Heinrich Förster, Barbara Uchanska-Ziegler, and Andreas Ziegler

Humanization of Monoclonal Antibodies by CDR Grafting
Siobhan O'Brien and Tarran Jones

Part III. Recombinant Antibody Fragments from Phagemid-Displayed Antibody Repertoires

Generation and Screening of a Modular Human scFv Expression Library from Mulitple Donors
Martin Welschof, Christiane Christ, Ingrid Hermes, Armin Keller, Christian Kleist, and Michael Braunagel

Construction of Semisynthetic Antibody Libraries
Michael Braunagel

Single-Domain VH Antibody Fragments from a Phage Display Library
Liat Binyamin, Daniel Plaksin, and Yoram Reiter

Isolation of Human Fab Fragments Against Ovarian Carcinoma Using Guided Selection
Mariangela Figini, Andrew Green, Francesco Colotta, and Silvana Canevari

Human Recombinant Fab Antibodies with T-Cell Receptor-Like Specificities Generated from Phage Display Libraries
Jan Engberg, Ali F. Yenidunya, Rikke Clausen, Liselotte B. Jensen, Peter Sørensen, Pernille Kops, and Erik Riise

Engineering Hot Spots for Affinity Enhancement of Antibodies
Partha S. Chowdhury

Simultaneous Humanization and Affinity Optimization of Monoclonal Antibodies
Herren Wu

Tailoring Kinetics of Antibodies Using Focused Combinatorial Libraries
Herren Wu and Ling-Ling An

Part IV. Antibody Fragments with Additional Properties

Engineering scFvs for Improved Stability
Partha S. Chowdhury and George Vasmatzis

Recombinant Single-Chain and Disulfide-Stabilized Fv Immunotoxins for Cancer Therapy
Revital Niv, Dina Segal, and Yoram Reiter

Generation of Recombinant Immunotoxins for Specific Targeting of Tumor-Related Peptides Presented by MHC Molecules
Cyril J. Cohen, Galit Denkberg, Dina Segal, and Yoram Reiter

Construction and Characterization of RNase-Based Targeted Therapeutics
Dianne L. Newton, Junichiro Futami, Dale Ruby, and Susanna M. Rybak

Bispecific Diabodies for Cancer Therapy
Michaela Arndt and Jürgen Krauss

Generation and Characterization of Bispecific Tandem Diabodies for Tumor Therapy
Sergey M. Kipriyanov

Generation of Recombinant Multimeric Antibody Fragments for Tumor Diagnosis and Therapy
Barbara E. Power, Alexander A. Kortt, and Peter J. Hudson

Construction and Characterization of Minibodies for Imaging and Therapy of Colorectal Carcinomas
Paul J. Yazaki and Anna M. Wu

Generation, Expression, and Monitoring of Recombinant Immune Receptors for Use in Cellular Immunotherapy
Andreas Hombach, Claudia Heuser, and Hinrich Abken

Tailoring Natural Effector Functions: Antibody Engineering Beyond Humanization
Ole H. Brekke and John E. Thommesen

Single-Chain Fv-Based Affinity Purification of the Cellular Stress Protein gp96 for Vaccine Development
Christian Kleist, Daniele Arnold-Schild, Martin Welschof, Martina Finger, Gerhard Opelz, Hans-Georg Rammensee, Hansjörg Schild, and Peter Terness

Recombinant Adenoviruses for In Vivo Expression of Antibody Fragments
Roland E. Kontermann, Tina Korn, and Valérie Jérôme

Part V. Large Scale Production of Recombinant Antibodies for Clinical Application

Production of Antibody Fragments in a Bioreactor
Halldis Hellebust.

Large Scale Production of Recombinant Antibodies by Utilizing Cellulose-Binding Domains
Itai Benhar and Yevgeny Berdichevsky

Production of Tumor-Specific Antibodies in Tobacco
Carmen Vaquero-Martin and Rainer Fischer

Index



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