Koopman Organogenesis in Development

1. Auflage 2010
ISBN: 978-0-12-380913-1
Verlag: Elsevier Science & Techn.
Format: EPUB
Kopierschutz: 6 - ePub Watermark

E-Book, Englisch, Band Volume 90, 456 Seiten

Reihe: Current Topics in Developmental Biology

Understanding organogenesis is central to current efforts to direct stem cell differentiation and function in the context of a complex organ. Defects in organogenesis are often the major manifestations of human genetic disease syndromes. This volume describes the development of 10 major organ systems, reviewed by experts in each, to provide an up-to-date overview for researchers within and outside the field, students, teachers and clinicians. - Summarizes the key morphological and cellular events - Emphasizes up-to-date research relating to molecular control mechanisms - Draws on a range of model vertebrates and contemporary experimental approaches, including lessons learnt from human developmental disease - Distils common themes and differences for comparative studies - Highlights key remaining questions and sets the agenda for future research

Autoren/Hrsg.

Koopman, Peter

Inhaltsverzeichnis

1;Cover;1
2;Current Topics in Developmental Biology;2
3;Copyright;5
4;Contents;6
5;Contributors;10
6;Preface;14
7;Chapter 1. How to Make a Heart: The Origin and Regulation of Cardiac Progenitor Cells;16
7.1;1. Introduction;17
7.2;2. The Origin of the Heart Fields and Cardiac ProgenitorCell Behavior;20
7.3;3. Markers of Cardiac Progenitors and the Distinction Between Firstand Second Heart Fields (FHF and SHF);22
7.4;4. Cardiac Progenitor Contributions to the Cell Types of the Heart;25
7.5;5. Subdomains of the SHF;29
7.6;6. Molecular Mechanisms that Govern SHF Cell Behavior—Transcriptional Regulators and Signaling Pathways;33
7.7;7. Conclusion;44
7.8;Acknowledgments;45
7.9;References;45
8;Chapter 2. Vascular Development—Genetic Mechanisms and Links to Vascular Disease;58
8.1;1. Introduction;59
8.2;2. VEGF in Vascular Development;64
8.3;3. BMP in Vascular Development;68
8.4;4. Notch/Delta/Jagged in Vascular Development;70
8.5;5. Perspectives;75
8.6;Acknowledgments;77
8.7;References;77
9;Chapter 3. Lung Organogenesis;88
9.1;1. Introduction;89
9.2;2. Developmental Anatomy of the Lung;90
9.3;3. Molecular Embryology of the Lung;96
9.4;4. Mechanobiology of the Developing Lung;126
9.5;5. Stem/Progenitor Cell Biology of the Lung;133
9.6;6. Postnatal and Adult Lung;143
9.7;7. Conclusions;145
9.8;Acknowledgments;146
9.9;References;146
10;Chapter 4. Transcriptional Networks and Signaling Pathways that Govern Vertebrate Intestinal Development;174
10.1;1. Introduction;175
10.2;2. Formation of the Definitive Endoderm;177
10.3;3. The Formation and Regionalization of the Primitive Gut Tube 1654. Establishment of the Crypt–Villus Axis;180
10.4;4. Establishment of the Crypt–Villus Axis;190
10.5;5. Establishing the Stem Cell Niche and Homeostasis in the Intestinal Epithelium;194
10.6;6. Role of Intestinal Development Pathways in Cancer;200
10.7;Acknowledgments;201
10.8;References;201
11;Chapter 5. Kidney Development: Two Tales of Tubulogenesis;208
11.1;1. Introduction: How You Get a Kidney;209
11.2;2. The First Tale of Tubulogenesis: a Branching Tree;212
11.3;3. Tubulogenesis Via MET—Tube One Induces Tube Two;218
11.4;4. Patterning the Resulting Tubules;222
11.5;5. Moving From Structure to a Functional Filter;228
11.6;6. Disruptions to Kidney Tubulogenesis in Human Disease;232
11.7;7. Conclusion;235
11.8;Acknowledgments;236
11.9;References;236
12;Chapter 6. The Game Plan: Cellular and Molecular Mechanisms of Mammalian Testis Development;246
12.1;1. Introduction;247
12.2;2. Introducing the Players: Cell Biology and Morphologyof the Gonads;248
12.3;3. Origin of Sertoli Cells;250
12.4;4. Kickoff in Testis Determination: Sry and Sertoli Cell Specification;250
12.5;5. The Goalkeeper: Sox9 and Sertoli Cell Differentiation;252
12.6;6. Forward Players: Beyond Sox9;256
12.7;7. The Sweepers: Peritubular Myoid Cells;258
12.8;8. Interplay Between PM and Other Testicular Cells;260
12.9;9. The Midfielders: Leydig Cells;260
12.10;10. The White Lines: Endothelial Cells;264
12.11;11. What All the Fuss Is About: Germ Cells;266
12.12;12. Concluding Remarks;268
12.13;Acknowledgments;269
12.14;References;269
13;Chapter 7. Building Pathways for Ovary Organogenesis in the Mouse Embryo;278
13.1;1. Evolution of the Hypotheses for Ovary Organogenesis in Mammals;279
13.2;2. Building the Foundation: Morphogenesis of the Ovary;281
13.3;3. Making Eggs: Establishment of the Female Germline;283
13.4;4. Determination of the Ovarian Identity: Differentiation ofGranulosa Cells;287
13.5;5. Emerging Pathways for the Establishment of Female SomaticEnvironment and Maintenance of Female Germ Cells;291
13.6;6. Conclusion and Perspectives;293
13.7;References;298
14;Chapter 8. Vertebrate Skeletogenesis;306
14.1;1. Introduction;307
14.2;2. Structural Organization and Advantages of the Vertebrate Skeleton;308
14.3;3. Development of Skeletogenic Cells;309
14.4;4. Development of Cartilage Anlagen;313
14.5;5. Development of Cartilage Growth Plates;315
14.6;6. Bone Development;317
14.7;7. Synovial Joint Formation;321
14.8;8. Skeleton Variation;324
14.9;9. Perspectives;325
14.10;Acknowledgments;326
14.11;References;326
15;Chapter 9. The Molecular Regulation of Vertebrate Limb Patterning;334
15.1;1. Introduction;335
15.2;2. The Early Limb;337
15.3;3. Patterning Along the AP Axis;340
15.4;4. Proximal–Distal Patterning and Outgrowth;343
15.5;5. Interaction Between the ZPA and the AER;347
15.6;6. Towards a Systems Biology Approach to Limb Patterning;349
15.7;Acknowledgments;350
15.8;References;350
16;Chapter 10. Eye Development;358
16.1;1. Introduction;359
16.2;2. Overview of Eye Development;361
16.3;3. Early Stage: The Eye Field;361
16.4;4. Lens Development;369
16.5;5. The Cornea;378
16.6;6. The Iris and the Ciliary Body;381
16.7;7. The Retina;382
16.8;8. The Optic Nerve;389
16.9;9. Conclusion and Perspectives;392
16.10;Acknowledgments;393
16.11;References;393
17;Index;402
18;Contents of Previous Volumes;424