Klyosov / Witczak / Platt Galectins

1. Auflage 2008
ISBN: 978-0-470-37778-9
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 288 Seiten, E-Book

The comprehensive guide to the current understanding of galectinsand their promising potential in drug design
This is the first book focusing on galectins. It was inspired bytopics discussed at the symposium "Galectins: Structures,Functions, and Therapeutic Targets" that was a part of the 234thAmerican Chemical Society meeting in 2007. To help chemists,biochemists, and others understand the challenges inherent in thestudy of galectins and build on recent advances in the field, theeditors have compiled articles from leading experts on galectinsand their biomedical applications. Galectins includes:
* An overview of early galectin research
* An explanation of the nature of galectins
* A discussion of the structure and functions of galectins, theirligand specificity and molecular mechanisms of action, and thelocalization of galectins in the cell
* An exploration of the roles galectins play in tumor growth andcancer, fibrosis, inflammation, and immunity
* A discussion of the effect of galectins on cell migration,angiogenesis, and chemoresistance
* An introduction to new approaches to designing galectininhibitors
This is the premier reference on galectins for organic, medicinal,carbohydrate, and pharmaceutical chemists, biochemists, molecularand cell biologists, pharmacologists, cancer researchers, andgraduate-level students in these disciplines, as well as cliniciansand drug developers.

Autoren/Hrsg.

Klyosov, Anatole A.

Witczak, Zbigniew J.

Platt, David

Inhaltsverzeichnis

Preface.
1. Stumbling on Galectins (Samuel H. Barondes).
2. Galectins and their Functions in Plain Language (Anatole A.Klyosov).
3. Understanding Galectin Structure-Function Relationships toDesign Effective Antagonists (Irina V. Nesmelova, Ruud P.M. Dingsand Kevin H. Mayo).
4. Galectins as Regulators of Tumor Growth and Invasion byTargeting Distinct Cell Surface Glycans and Implications for DrugDesign (Hans-J. Gabius and Albert M. Wu).
5. Nuclear and Cytoplasmic Localization of Galectin-1 andGalectin-3 and their Roles in pre-mRNA Splicing (John L. Wang,Kevin C. Haudek, Patricia G. Voss and Ronald J. Patterson).
6. Galectins in Regulation of Inflammation and Immunity (Fu-TongLiu, Daniel K. Hsu, Ri-Yao Yang, Huan-Yuan Chen and JunSaegusa).
7. Galectins as Danger Signals in Host-Pathogen and Host-TumorInteractions: New Members of the Growing Group of "Alarmins"(Sachiko Sato and Gabriel Rabinovich).
8. The Role of Galectins in Organ Fibrosis (Neil C. Hendersonand Tariq Sethi).
9. Galectin-1, Cancer Cell Migration, Angiogenesis andChemoresistance (Florence Lefranc, Marie Le Mercier, VéroniqueMathieu and Robert Kiss).
10. Galectin-3 in the Progression and Metastasis of ColorectalNeoplasia (James C. Byrd and Robert S. Bresalier).
11. Galectins in Malignant Gliomas: Expression, Functions andPossible Therapeutic Options (Herwig M. Strik and AnnaHoffman).
12. Food-Related Carbohydrate Ligands for Galectins (Valeri V.Mossine, Vladislav V. Glinsky and Thomas P. Mawhinney).
Index.

Über Autor(innen)

Anatole A. Klyosov, PhD, is Chief Scientist and cofounder ofPro-Pharma-ceuticals, Inc. He has published more than 290peer-reviewed articles in scientific journals; authored and editedbooks on enzymes, carbohydrates, and biotechnology, includingWood-Plastic Composites (Wiley); and holds thirty-nine patents.
Zbigniew J. Witczak, PhD, has extensive industrial and academicexperience in carbohydrates. He has published more than ninetyresearch papers and holds six patents in the fields ofcarbohydrate, medicinal, and biological chemistry. In 2000, Dr.Witczak was awarded the Melville L. Wolfrom Award of the ACSDivision of Carbohydrate Chemistry for his outstanding researchcontribution to carbohydrate chemistry and service to thedivision.
David Platt, PhD, is Chief Executive Officer and cofounder ofPro-Pharmaceuticals, Inc. He has published peer-reviewed articlesand holds many patents, primarily in the field of carbohydratechemistry. Dr. Klyosov, Dr. Witczak, and Dr. Platt coedited the ACSsymposium book Carbohydrate Drug Design.