Karlin / Itoh / Rokita Copper-Oxygen Chemistry

1. Auflage 2011
ISBN: 978-1-118-09435-8
Verlag: John Wiley & Sons
Format: EPUB
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, Band 4, 480 Seiten, E-Book

Reihe: Wiley Series of Reactive Intermediates

Covers the vastly expanding subject of oxidative processesmediated by copper ions within biological systems
Copper-mediated biological oxidations offer a broad range offundamentally important and potentially practical chemicalprocesses that cross many chemical and pharmaceutical disciplines.This newest volume in the Wiley Series on ReactiveIntermediates in Chemistry and Biology is divided into threelogical areas within the topic of copper/oxygen chemistry--biological systems, theory, and bioinorganic models andapplications--to explore the biosphere for its highly evolvedand thus efficient oxidative transformations in the discovery ofnew types of interactions between molecular oxygen and copper ion.Featuring a diverse collection of subject matter unified in onecomplete and comprehensive resource, Copper-Oxygen Chemistry probesthe fundamental aspects of copper coordination chemistry, syntheticorganic chemistry, and biological chemistry to reveal both thebiological and chemical aspects driving the current excitingresearch efforts behind copper-oxygen chemistry. In addition,Copper-Oxygen Chemistry:
* Addresses the significantly increasing literature on oxygen-atominsertion and carbon-carbon bond-forming reactions as well asenantioselective oxidation chemistries
* Progresses from biological systems to spectroscopy and theory,and onward to bioinorganic models and applications
* Covers a wide array of reaction types such as insertion anddehydrogenation reactions that utilize the cheap, abundant, andenergy-containing O2 molecule
With thorough coverage by prominent authors and researchersshaping innovations in this growing field, this valuable referenceis essential reading for bioinorganic chemists, as well as organic,synthetic, and pharmaceutical chemists in academia andindustry.

Autoren/Hrsg.

Karlin, Kenneth D.

Itoh, Shinobu

Rokita, Steven

Inhaltsverzeichnis

Preface to Series vii
Introduction ix
Contributors xi
1 Insights into the Proposed Copper-Oxygen Intermediatesthat Regulate the Mechanism of Reactions Catalyzed by Dopamineb-Monooxygenase, Peptidylglycine a-Hydroxylating Monooxygenase, andTyramine b-Monooxygenase 1
Robert L. Osborne and Judith P. Klinman
2 Copper Dioxygenases 23
Jozsef Kaizer, Jozsef Sandor Pap, and Gabor Speier
3 Amine Oxidase and Galactose Oxidase 53
Dalia Rokhsana, Eric M. Shepard, Doreen E. Brown, and David M.Dooley
4 Energy Conversion and Conservation by Cytochrome Oxidases107
Angela Paulus and Simon de Vries
5 Multicopper Proteins 131
Takeshi Sakurai and Kunishige Kataoka
6 Structure and Reactivity of Copper-Oxygen SpeciesRevealed by Competitive Oxygen-18 Isotope Effects 169
Justine P. Roth
7 Theoretical Aspects of Dioxygen Activation in Dicopper Enzymes197
Kazunari Yoshizawa
8 Chemical Reactivity of Copper Active-Oxygen Complexes225
Shinobu Itoh
9 Cytochrome c Oxidase and Models 283
Zakaria Halime and Kenneth D. Karlin
10 Supramolecular Copper Dioxygen Chemistry 321
Jean-Noel Rebilly and Olivia Reinaud
11 Organic Synthetic Methods Using Copper Oxygen Chemistry361
Marisa C. Kozlowski
Index 445

Über Autor(innen)

Kenneth D. Karlin is Ira Remsen Professor of Chemistry atJohns Hopkins University. His bioinorganic research focuses oncoordination chemistry relevant to biological and environmentalprocesses, involving copper or heme (porphyrin-iron) complexes. Dr.Karlin's main approach involves synthetic modeling, i.e.,biomimetic chemistry. He is the winner of the prestigious F. AlbertCotton Award in Synthetic Inorganic Chemistry and the Sierra NevadaDistinguished Chemist Award, both awarded in 2009.
Shinobu Itoh focuses his current research on chemicalmodeling and application of novel active sites in biologicalsystems. He was formerly an assistant professor at OsakaUniversity, where he worked on the chemistry of coenzyme PQQ andcofactor TTQ as well as model compounds of galactose oxidase. In1994, he was promoted to associate professor at Osaka University,where he collaborated with Professor Shunichi Fukuzumi incopper-dioxygen chemistry research. In 1999, he moved to Osaka CityUniversity as a full professor and started biological studies ofdinuclear copper proteins, such as hemocyanin and tyrosinase. Hereturned to Osaka University in 2008 and further expanded hisresearch interests to the design of artificial non-hememetalloenzymes using genetic engineering.