Jackson / Wunner Rabies

1. Auflage 2002
ISBN: 978-0-08-052513-6
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 800 Seiten, Web PDF

Rabies offers a complete account of one of the oldest known diseases threatening public health today. Unlike most research-oriented descriptions of rabies, this book provides a narrative about the disease and its etiologic agent, encompassing the historical background to recent developments. The emphasis on the basic biology and molecular virology of the disease is intended to convey an understanding of the underlying mechanisms involved in the disease - essential information for diagnosis and prevention strategies. Current methods used in defining geographic origins and animal species of rabies viruses in wildlife are presented, along with diagnostic methods for identifying the strain of virus based on its genomic sequence and antigenic structure. The latest approved methods for controlling rabies in wildlife species are also covered. This account of rabies will interest clinicians, public health advisors, epidemiologists, research scientists, and anyone involved in diagnosing, treating, controlling, and preventing this disease.Key Features* A history of rabies from antiquity to the modern era* Basic biology and molecular virology* Epidemiological aspects* Pathogenesis and pathology of the disease* Clinical manifestations and diagnostic evaluation in humans and animals* Preventive measures in humans and animals

Autoren/Hrsg.

Jackson, Alan C.

Wunner, William H.

Inhaltsverzeichnis

1;Front Cover;1
2;Rabies;4
3;Copyright Page;5
4;Contents;6
5;Contributors;12
6;Foreword;14
7;Preface ;18
8;Chapter 1. History;20
8.1;I. Text;20
8.2;References ;40
9;Chapter 2. Rabies Virus;42
9.1;I. Introduction ;42
9.2;II. Rabies Virus Structure;44
9.3;III. Intracellular Life Cycle of Rabies Virus;54
9.4;IV. Genome Variability;64
9.5;V. Virus Spread;65
9.6;VI. Molecular Biology of Rabies Virus Proteins;66
9.7;References;80
10;Chapter 3. Molecular Epidemiology;98
10.1;I. Introduction;98
10.2;II. Methods and Definition of Terms;100
10.3;III. Insights: Aspects of Rabies Epidemiology and Pathogenesis Revealed by Molecular Methods of Epidemiologic Investigation ;117
10.4;IV. Conclusions;127
10.5;References;127
11;Chapter 4. Epidemiology;132
11.1;I. Introductory Concepts;133
11.2;II. The Epidemiology of Human Rabies;135
11.3;III. Epidemiology of Rabies in Domestic Animals;145
11.4;IV. Epidemiology of Rabies in Wildlife;154
11.5;V. Epidemiology of Other Lyssaviruses;164
11.6;References;168
12;Chapter 5. Animal Rabies;182
12.1;I. Introduction;182
12.2;II. Host Range;183
12.3;III. Susceptibility and Transmission;184
12.4;IV. Clinical Course ;187
12.5;V. Differential Diagnosis;249
12.6;VI. A Question of Immunity?;192
12.7;VII. Reservoirs and Other Lyssaviruses;193
12.8;VIII. Rabies in Domestic Animals;196
12.9;IX. Wildlife Reservoirs;204
12.10;X. Other Animals as Reservoirs;220
12.11;XI. Conclusions;225
12.12;References;226
13;Chapter 6. Human Disease;238
13.1;I. Introduction;238
13.2;II. Exposures and Incubation Period;239
13.3;III. Clinical Forms of Disease;241
13.4;IV. Investigations;246
13.5;V. Differential Diagnosis;249
13.6;VI. Therapy;251
13.7;VII. Recovery from Rabies;251
13.8;VIII. Rabies due to Other Lyssavirus Genotypes;254
13.9;References;256
14;Chapter 7. Pathogenesis;264
14.1;I. Introduction;265
14.2;II. Events at the Site of Exposure;265
14.3;III. Spread to the CNS;271
14.4;IV. Spread within the CNS;272
14.5;V. Spread from the CNS;273
14.6;VI. Animal Models of Rabies Virus Neurovirulence;275
14.7;VII. Rabies Virus Receptors;279
14.8;VIII. Brain Dysfunction in Rabies;281
14.9;IX. Recovery from Rabies and Chronic Rabies Virus Infection;291
14.10;X. Summary;293
14.11;References;293
15;Chapter 8. Pathology;302
15.1;I. Introduction;302
15.2;II. Histopathology of Rabies Encephalomyelitis;303
15.3;III. Involvement of the Peripheral Nervous System;309
15.4;IV. Involvement of Extraneural Organs;311
15.5;V. Pathology of Paralytic Rabies;312
15.6;VI. Ultrastructural Observations;313
15.7;VII. Conclusions;321
15.8;References;322
16;Chapter 9. Diagnostic Evaluation;326
16.1;I. Introduction;327
16.2;II. Postmortem Diagnosis of Rabies in Animals;328
16.3;III. Virus Isolation;341
16.4;IV. Detection of Viral RNA by Molecular Methods;342
16.5;V. Diagnosis of Rabies in Humans;356
16.6;VI. Rabies Antibody Assays;361
16.7;References;363
17;Chapter 10. Immunology;370
17.1;I. Introduction;370
17.2;II. Molecular Components of a Specific Immune Response;371
17.3;III. Immune Responses during Rabies Virus Infection;372
17.4;IV. Immunologic Basis for Postexposure Vaccination Efficiency;380
17.5;V. Conclusions;383
17.6;References;384
18;Chapter 11. Vaccines;390
18.1;I. Human Rabies Vaccines;391
18.2;II. Rabies Vaccines for Domestic Animals;397
18.3;III. The Next Generation of Rabies Vaccines;404
18.4;References;411
19;Chapter 12. Public Health Management of Humans at Risk;420
19.1;I. Introduction;420
19.2;II. Preexposure Vaccination;423
19.3;III. Postexposure Treatment;428
19.4;IV. Travel to Developing Countries;436
19.5;V. Adverse Reactions to Cell-Culture Vaccines;438
19.6;VI. Interchangeability of Vaccines;438
19.7;VII. Large-Scale Human Exposures;439
19.8;VIII. Rabies Vaccination of Animals;439
19.9;IX. Postexposure Treatment in Developing Countries;440
19.10;References;442
20;Chapter 13. Control of Dog Rabies;448
20.1;I. Introduction;448
20.2;II. History;449
20.3;III. Dog Accessibility: A New Term in Canine Rabies Control;454
20.4;IV. Present Approaches to Dog Rabies Control;456
20.5;V. Significance of Public Awareness and Interdisciplinary Collaboration;458
20.6;VI. Research on Oral Vaccination;459
20.7;VII. Summary;460
20.8;References ;461
21;Chapter 14. Rabies Control in Wildlife;464
21.1;I. The Concept of Controlling Rabies in Wildlife;465
21.2;II. Chiropteran Rabies Control;466
21.3;III. Initiation of Wildlife Rabies Control Programs;466
21.4;IV. Diagnosis of Suspect Wildlife;468
21.5;V. Animal Population Reduction: The First Call for Control;468
21.6;VI. Vector Species Biology, Epidemiology, and Genetics;469
21.7;VII. Transportation of Wildlife;470
21.8;VIII. Oral Rabies Vaccine Development;470
21.9;IX. Vaccine Bait Development;470
21.10;X. Biomarkers;471
21.11;XI. ORV Initiation;473
21.12;XII. Importance of the Home Range of Vector Species in Bait Distribution;474
21.13;XIII. Large-Scale Vaccine Bait Distribution Technology;475
21.14;XIV. Postdrop Surveillance of Target Species;477
21.15;XV. Vaccine Baiting Costs;478
21.16;XVI. Vaccine Baiting Efficiency and Cost Reduction;479
21.17;XVII. Baiting Success Guidelines;480
21.18;XVIII. Modeling;482
21.19;XIX. Program Perpetuation ;483
21.20;References;484
22;Chapter 15. Future Developments and Challenges ;492
22.1;I. Introduction;492
22.2;II. Pathogenesis;493
22.3;III. Epidemiology and Molecular Epidemiology;493
22.4;IV. Prevention of Human Rabies and Control of Animal Rabies;494
22.5;V. Diagnosis and Therapy of Human Disease;496
22.6;VI. Summary;496
22.7;References;497
23;Index;500