Computer Techniques in Preclinical and Clinical Drug Development

1. Auflage 2019
ISBN: 978-0-367-40128-3
Verlag: CRC Press

Buch, Englisch, 256 Seiten, Format (B × H): 156 mm x 234 mm, Gewicht: 363 g

It is estimated that 80 to 90% of drugs under development never make it to the marketplace due to insufficient clinical activity, unacceptable toxicity, rapid appearance of drug resistance, or other factors that should be, at least partially, predictable from preclinical testing. This new text asks the question, "How can we use computational methods to improve the success rate in drug development?" Computer Techniques in Preclinical and Clinical Drug Development shows how modeling makes it possible to extract the maximum amount of information and predictive value from preclinical data. Computer modeling methods from the areas of pharmacokinetics, pharmacodynamics, cytokinetics, and inhibition kinetics of multi-enzyme pathways are all discussed in this unique reference source.

Zielgruppe

Academic and Professional Practice & Development

Autoren/Hrsg.

Jackson, Robert C

Fachgebiete

• Naturwissenschaften Chemie Chemie Allgemein
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie

Inhaltsverzeichnis

Introduction: The Preclinical and Clinical Drug Development Process Physiological Pharmacokinetic Modeling Interspecies Scaling Prediction of Drug Metabolism and Toxicity Pharmacodynamic Modeling Cytokinetic Modeling Prediction of Drug Resistance Conclusions: The Virtual Clinical Trial References Appendix: Computational Pharmacology Software Suppliers Abbreviations Index

Über Autor(innen)

Jackson, Robert C.