Inhibitors of the Ras Superfamily G-proteins, Part A

Erscheinungsjahr 2013
ISBN: 978-0-12-416749-0
Verlag: William Andrew Publishing

Buch, Englisch, 364 Seiten, Format (B × H): 152 mm x 229 mm, Gewicht: 710 g

This special volume of The Enzymes is targeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer. This thematic volume discusses inhibitors of the Ras superfamily G-proteins.

Zielgruppe

Researchers in biochemistry, molecular and cell biology, pharmacology, and cancer

Autoren/Hrsg.

Weitere Mitwirkende

Tamanoi, Fuyuhiko

Fachgebiete

• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
• Naturwissenschaften Biowissenschaften Enzymologie
• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Biowissenschaften Zellbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie

Inhaltsverzeichnis

- The Ras superfamily G-proteins

Fuyuhiko Tamanoi
- NMR Study to Identify a Ligand-Binding Pocket in Ras

Till Maurer and Weiru Wang
- The Allosteric Switch and Conformational States in Ras GTPase Affected by Small Molecules
Christian W. Johnson and Carla Mattos
- State 1(T) Inhibitors of Activated Ras
Hans Robert Kalbitzer and Michael Spoerner
- Sugar-Based Inhibitors of Ras Activation: Biological Activity and Identification of Ras-Inhibitor Binding Interface

Alessandro Di Domizio and Francesco Peri

- Development of EHop-016, a Small Molecule Inhibitor of Rac
Suranganie Dharmawardhane

- Aptamer-Derived Peptide Inhibitors of Rho Guanine Nucleotide Exchange Factors

Susanne Schmidt and Anne Debant
- Targeting the Dbl and Dock-Family RhoGEFs: a Yeast-Based Assay to Identify Cell-Active Inhibitors of Rho-Controlled Pathways

Anne Blangy and Philippe Fort
- Inhibitors of the ROCK Serine/Threonine Kinases: Key Effectors of the RhoA Small GTPase
Dominico Vigil and Channing J. Der
- A Two-Hybrid Approach to Identify Inhibitors of the RAS-RAF Interaction
Vladimir Khazak, Susanne Eyrisch, Juran Kato, Fuyuhiko Tamanoi and Erica A. Golemis

- Inhibitors of K-Ras Plasma Membrane Localization
Kwang-jin Cho, Dharini van der Hoeven and John F. Hancock

- Ras Chaperons: New Targets for Cancer and Immunotherapy
Yoel Kloog, Galit Elad-Sfadia, Roni Haklai and Adam Mor

Über Autor(innen)

Tamanoi, Fuyuhiko
Fuyu Tamanoi is a biochemist who has served on the UCLA School of Medicine and UCLA College faculty since he joined the Department of Microbiology, Immunology & Molecular Genetics in 1993. He became a full professor in 1997.