Hood Developmental and Reproductive Toxicology

A Practical Approach
3. Auflage 2011
ISBN: 978-1-84184-821-1
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 1168 Seiten

Completely revised and updated, Developmental and Reproductive Toxicology: A Practical Approach, Second Edition draws together valuable information typically scattered throughout the literature, plus some not previously published, into one complete resource. In addition to the traditional aspects of developmental toxicity testing, the book covers evaluating and interpreting data. Originally titled Handbook of Developmental Toxicology, the second edition's new name reflects significant changes in its content and scope.

New coverage in the Second Edition:

- Genomics and proteomics

- Tests for endocrine disruptors

- Testing for male and female reproductive toxicity

- Extensive treatment of the significance, reliability, and interpretation of developmental and reproductive toxicity data

- Toxicity testing in neonatal and juvenile animals

- Postnatal developmental milestones

- FDA perspective on risk assessment

- Extensive glossaries of developmental defect terminology

Previous books on this subject have largely been academically oriented and not intended to guide the practicing developmental or reproductive toxicologist. Useful and informative, this book blends the theoretical foundation with insights gained from hands-on experience. It includes tables of comparative developmental milestones - both pre- and postnatal, glossaries of descriptive terms used in developmental toxicity evaluation, and both US and international regulatory guidelines. Bridging the gap between theory and application, this is a handy single-source of essential information to use in planning, conducting, and interpreting studies.

Zielgruppe

Toxicologists, teratologists, developmental biologists, regulatory personnel in health and environmental agencies, and toxicologic pathologists

Autoren/Hrsg.

Hood, Ronald D

Fachgebiete

• Naturwissenschaften Biowissenschaften Entwicklungsbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Reproduktionsmedizin
• Naturwissenschaften Biowissenschaften Toxikologie

Inhaltsverzeichnis

PRINCIPLES AND MECHANISMS
Principles of Developmental Toxicology Revisited, R.D. Hood
Experimental Approaches to Evaluate Mechanisms of Developmental Toxicity, E.M. Faustman, J.M. Gohlke, R.A. Ponce, T.A. Lewandowski, M.R. Seeley, S.G. Whittaker, and W.C. Griffith
Pathogenesis of Abnormal Development, L.B. Fawcett and R.L. Brent
Maternally-Mediated Effects on Development, R.D. Hood and D.B. Miller
Paternally-Mediated Effects on Development, B.F. Hales and B. Robaire
Comparative Features of Vertebrate Embryology, J.M. DeSesso

HAZARD AND RISK ASSESSMENT AND REGULATORY GUIDANCE
Developmental Toxicity Testing - Methodology, R.W. Tyl and M.C. Marr
Nonclinical Juvenile Toxicity Testing, M.J. Beck, E.L. Padgett, C.J. Bowman, D.T. Wilson, L.E. Kaufman, B.J. Varsho, D.G. Stump, M.D. Nemec, and J.F. Holson
Significance, Reliability, and Interpretation of Developmental and Reproductive Toxicity Study Findings, J. Holson, M.D. Nemec, D.G. Stump, L.E. Kaufman, P. Lindström, and B.J. Varsho
Testing for Reproductive Toxicity, R.M. Parker
The U.S. EPA Endocrine Disruptor Screening Program: In Vitro and In Vivo Mammalian Tier I Screening Assays, S.C. Laws, T.E. Stoker, J.M. Goldman, V. Wilson, L.E. Gray, Jr., and R.L. Cooper
Role of Xenobiotic Metabolism in Developmental and Reproductive Toxicity, A.P. Kulkarni
Use of Toxicokinetics in Developmental and Reproductive Toxicology, P.J. Wier
Cellular, Biochemical, and Molecular Techniques in Developmental Toxicology, B.D. Abbott, M.B. Rosen, and G. Held
Functional Genomics and Proteomics in Developmental and Reproductive Toxicology, O. Spiegelstein, R.M. Cabrera, and R.H. Finnell
In Vitro Methods for the Study of Mechanisms of Developmental Toxicology, C. Harris and J.M. Hansen
Statistical Analysis for Developmental and Reproductive Toxicologists, J.J. Chen
Quality Concerns for Developmental and Reproductive Toxicologists, K.D. Barrowclough and K.L. Reed
Perspectives on the Developmental and Reproductive Toxicity Guidelines, M.S. Christian, A.M. Hoberman, and E.M. Lewis
Human Studies - Epidemiologic Techniques in Developmental and Reproductive Toxicology, B. Källén
Developmental and Reproductive Toxicity Risk Assessment for Environmental Agents, C.A. Kimmel, G.L. Kimmel, and S.Y. Euling
Principles of Risk Assessment-FDA Perspective, T.F.X. Collins, R.L. Sprando, M.E. Shackelford, M.F. Gruber, and D.E. Morse

APPENDICES
A. Terminology of Anatomical Defects
B. Books Related to Developmental and Reproductive Toxicology
C. Postnatal Developmental Milestones