Herceg / Ushijima Epigenetics and Cancer, Part B

1. Auflage 2010
ISBN: 978-0-12-380865-3
Verlag: Elsevier Science & Techn.
Format: EPUB
Kopierschutz: 6 - ePub Watermark

E-Book, Englisch, Band Volume 71, 314 Seiten

Reihe: Advances in Genetics

Genes interact with the environment, experience, and biology of the brain to shape an animal's behavior. This latest volume in Advances in Genetics, organized according to the most widely used model organisms, describes the latest genetic discoveries in relation to neural circuit development and activity. - Explores the latest topics in neural circuits and behavior research in zebrafish, drosophila, C.elegans, and mouse models - Includes methods for testing with ethical, legal, and social implications - Critically analyzes future prospects

Autoren/Hrsg.

Herceg, Zdenko

Ushijima, Toshikazu

Inhaltsverzeichnis

1;Front Cover;1
2;Epigenetics and Cancer, Part B;4
3;Copyright;5
4;Contents;6
5;Contributors;10
6;Preface;12
7;Section I: Epigenetic Changes Induced by Environmental and Dietary/Lifestyle Factors;14
7.1;Chapter 1: Induction of Epigenetic Alterations by Dietary and Other Environmental Factors;16
7.1.1;I. Introduction;17
7.1.2;II. Induction of Epigenetic Alterations by Dietary and Other Environmental Factors;22
7.1.3;III. Conclusions;40
7.1.4;Acknowledgments;42
7.1.5;References;43
7.2;Chapter 2: Induction of Epigenetic Alterations by Chronic Inflammation and Its Significance on Carcinogenesis;54
7.2.1;I. Introduction;55
7.2.2;II. Traditional Views on How Inflammation Leads to Cancers;56
7.2.3;III. Epigenetic Alteration Induced by Inflammation and Its Significance on Carcinogenesis;57
7.2.4;IV. Mechanisms for Induction of Epigenetic Alterations by Inflammation;62
7.2.5;V. Conclusions;65
7.2.6;Acknowledgment;66
7.2.7;References;66
7.3;Chapter 3: In Utero Life and Epigenetic Predisposition for Disease;70
7.3.1;I. Introduction to Programming;71
7.3.2;II. Programming and Cancer;74
7.3.3;III. Dynamic Changes in the Epigenome During Mammalian Development;76
7.3.4;IV. Environmental Perturbation of the Epigenome and the Developmental Origins of Disease;78
7.3.5;V. Mechanisms Involved in Dietary Modulation of Epigenetic Modification;79
7.3.6;VI. Maternal Diet and Risk of Cancer in Offspring: Human Studies;82
7.3.7;VII. The Placenta as a Programming Factor;84
7.3.8;VIII. Conclusions;84
7.3.9;Acknowledgments;85
7.3.10;References;86
7.4;Chapter 4: Folate and One-Carbon Metabolism and Its Impact on Aberrant DNA Methylation in Cancer;92
7.4.1;I. Introduction;93
7.4.2;II. Chemistry and Metabolism of Folate;94
7.4.3;III. Biochemistry of Cellular Folate-Mediated One-Carbon Metabolism;97
7.4.4;IV. Characteristics of DNA Hypomethylation in Cancer;109
7.4.5;V. Folate Deficiency, DNA Hypomethylation, and CRC: A Critical Review;110
7.4.6;VI. Conclusion;122
7.4.7;Acknowledgments;124
7.4.8;References;124
8;Section II: Epigenetic Biomarkers;136
8.1;Chapter 5 Epigenetic Alterations as Cancer Diagnostic, Prognostic, and Predictive Biomarkers;138
8.1.1;I. Introduction;139
8.1.2;II. DNA Methylation;141
8.1.3;III. MicroRNAs;160
8.1.4;IV. Other Epigenetic Alterations;168
8.1.5;V. Prospective and Challenges;169
8.1.6;References;171
8.2;Chapter 6: Detection of DNA Methylation Changes in Body Fluids;190
8.2.1;I. Introduction;191
8.2.2;II. DNA Methylation Detection Techniques and Methodologies;192
8.2.3;III. DNA Methylation Biomarker Discovery and Validation;194
8.2.4;IV. DNA Methylation Detection in Sputum and Bronchial Washings;197
8.2.5;V. DNA Methylation Detection in Saliva;199
8.2.6;VI. DNA Methylation Detection in Blood, Plasma, and Serum;200
8.2.7;VII. DNA Methylation Detection in Urine;202
8.2.8;VIII. DNA Methylation Detection in Pancreatic, Duodenal, and Gastric Juice;208
8.2.9;IX. DNA Methylation Detection in Breast Ductal Fluid;209
8.2.10;X. Conclusions;209
8.2.11;Acknowledgments;210
8.2.12;References;211
9;Section III: Application of Epigenetics in Molecular Epidemiology and Epigenetic Cancer Prevention;222
9.1;Chapter 7: Epigenetics in Molecular Epidemiology of Cancer;224
9.1.1;I. Introduction;225
9.1.2;II. Factors Affecting Epigenetic Statuses;226
9.1.3;III. Blood Leukocyte DNA Methylation Statuses in Cancer Cases and Control;239
9.1.4;IV. Conclusion;243
9.1.5;Acknowledgment;244
9.1.6;References;245
9.2;Chapter 8: Diet, Epigenetic, and Cancer Prevention;250
9.2.1;I. Introduction;251
9.2.2;II. Dietary Compounds Affecting DNA Methylation;252
9.2.3;III. Dietary Compounds Affecting Histone Modification;257
9.2.4;IV. Dietary Compounds Affecting MicroRNA;261
9.2.5;V. Perspectives;262
9.2.6;Acknowledgments;263
9.2.7;Reference;263
10;Section IV: Epigenetic Databases;270
10.1;Chapter 9: Epigenetic Databases and Computational Methodologies in the Analysis of Epigenetic Datasets;272
10.1.1;I. Introduction;273
10.1.2;II. Basic Epigenetic Tools;274
10.1.3;III. Epigenetic Databases;286
10.1.4;IV. Cancer Databases;293
10.1.5;V. Computational Approaches in Epigenetics;295
10.1.6;VI. Applications and Data Analysis in Cancer Epigenetics;297
10.1.7;VII. Conclusions;305
10.1.8;Acknowledgments;306
10.1.9;References;306
11;Index;310