Havlicek / Spizek Natural Products Analysis

Instrumentation, Methods, and Applications
1. Auflage 2014
ISBN: 978-1-118-87602-2
Verlag: John Wiley & Sons
Format: EPUB
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 624 Seiten, E-Book

This book highlights analytical chemistry instrumentation andpractices applied to the analysis of natural products and theircomplex mixtures, describing techniques for isolating andcharacterizing natural products.
* Applies analytical techniques to natural productsresearch - an area of critical importance to drugdiscovery
* Offers a one-stop shop for most analytical methods:x-ray diffraction, NMR analysis, mass spectrometry, and chemicalgenetics
* Includes coverage of natural products basics andhighlights antibacterial research, particularly important asefforts to combat drug resistance gain prominence
* Covers instrumental techniques with enough detail forboth current practitioners and beginning researchers

Autoren/Hrsg.

Havlicek, Vladimir

Spizek, Jaroslav

Inhaltsverzeichnis

Preface ix
Contributors xi
1. Natural Products Analysis: Instrumentation, Methods, andApplications 1
Vladimír Havlíèek and JaroslavSpí?ek
2. The Need for New Antifungal and Antimalarial Compounds9
Jaroslav Spí?ek and Arnold L. Demain
3. Emerging Instrumental Methods for Antimicrobial Resistanceand Virulence Testing 25
Plamen A. Demirev
4. Plant and Marine Sources: Biological Activity of NaturalProducts and Therapeutic Use 43
Amedeo Amedei and Elena Niccolai
5. Emerging Trends for Stimulating the Discovery of NaturalProducts 115
Navid Adnani, Gregory A. Ellis, Thomas P. Wyche, Tim S. Bugni,Jason C. Kwan, and Eric W. Schmidt
6. Advances and Challenges in Optical Molecular SpectroscopyIncluding Surface Plasmon Resonance-Based Methods for Bioanalysis163
Pavel Matìjka, Blanka Vlèková, LucieBednárová, and Petr Malon
7. Advanced Techniques for NMR Analysis of Complex BiologicalMixtures--From Simple NMR to Hyphenated Techniques 239
Helena Pelantová, Simona Bártová, and MarekKuzma
8. Advances in X-Ray Diffraction: Implications to thePharmaceutical Industry 285
Alexandr Jegorov and Michal HuSák
9. Laser Ablation Inductively Coupled Plasma Mass Spectrometryas a Tool in Biological Sciences 313
Michaela VaSinová Galiová, Jan HavliS, andViktor Kanicky
10. Imaging Mass Spectrometry, Metabolism, and New Views of theMicrobial World 349
B. Christopher Hoefler and Paul D. Straight
11. Structural Separations for Natural Product Characterizationby Ion Mobility-Mass Spectrometry: Fundamental Theory toEmerging Applications 397
Sarah M. Stow, Nichole M. Lareau, Kelly M. Hines, C. RuthMcNees, Cody R. Goodwin, Brian O. Bachmann, and John A.McLean
12. High-Resolution Tandem Mass Spectrometry for NonribosomalPeptide and Polyketide Analysis 433
Rebecca H. Wills, Manuela Tosin, and Peter B.O'Connor
13. Natural Product Drug Discovery and Analysis Using MassSpectrometry and Affinity-Based Technologies 475
Evelyn H. Wang and Kevin A. Schug
14. Glycosylated Ribosomally Synthesized Peptide Toxins:Discovery, Characterization, and Applications 507
Gillian E. Norris and Mark L. Patchett
15. Using Ultrahigh-Resolution Mass Spectrometry to Unravel theChemical Space of Complex Natural Product Mixtures 545
Constanze Müller, Mourad Harir, Norbert Hertkorn, BasemKanawati, Dimitrios Tziotis, and Philippe Schmitt-Kopplin
16. Functional Amyloid Fibrils: Lessons from Microbes 571
Sally L. Gras and Dennis Claessen
Index 601

Über Autor(innen)

Vladimir Havlicek is a Professor of Analytical Chemistry in the Institute of Microbiology of the Academy of Sciences of the Czech Republic. His laboratory uses analytical tools to characterize molecular structure. He has worked in the field of natural products for over 20 years. Dr. Havlicek is on the editorial or advisory boards of several leading analytical journals and has published over 130 papers in peer-reviewed journals.Jaroslav Spizek is a Professor of Molecular and Cell Biology and Genetics in the Institute of Microbiology of the Academy of Sciences of the Czech Republic, where he was director between1992-2000. He has worked in the field of antibiotics for 50 years. In 2011, he became an Elected Fellow of the American Academy of Microbiology. Professor Spizek has published 98 peer-reviewed papers and edited two books.