Reconstructive Transplantation and Regenerative Surgery

The New Frontier Volume 3
Erscheinungsjahr 2025
ISBN: 978-0-443-30084-4
Verlag: Elsevier Science

Buch, Englisch, 300 Seiten, Format (B × H): 216 mm x 276 mm

Reconstructive Transplantation and Regenerative Surgery: The New Frontier, Volume Three in the Regenerative and Transplant Medicine series-explores this transformative discipline. This integration aims to overcome the limitations of traditional vascularized organ and tissue transplantation, offering innovative solutions through cutting-edge techniques. As regenerative surgery continues to evolve, this volume serves as a comprehensive resource, highlighting the latest advancements in graft immunomodulation, neuroregeneration, gene editing, diagnostic imaging, ischemia mitigation, and graft preservation. Authored by leading experts, this volume delves into crucial topics such as cell therapies, immunobiologics, neurobiologics, and targeted therapeutic strategies like local immunosuppressive implants and immunocloaking.

It also covers cutting-edge diagnostic approaches, including non-invasive molecular imaging, nanotheranostics, and multimodal surveillance techniques. By addressing critical challenges in transplantation and regeneration, this book is an essential reference for surgeons, clinicians, trainees, scientists, and academics dedicated to advancing the field.

Autoren/Hrsg.

Gorantla, Vijay

Kulahci, Yalcin

Zor, Fatih

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften

Inhaltsverzeichnis

Part I - History of Reconstructive Transplantation
1. Emergence of Reconstructive Transplantation and the Evolution of Regenerative Surgery

Part II - Program, Patient and Policy Update
2. Current Status of VCA - A World Update
3. Complications and Mortality in VCA
4. The UNOS - OPTN Mandate for VCA - Emerging Policy and Impact

Part III - Decisions and Dilemmas in Reconstructive Transplantation
5. Lower Limb Transplantation - World Experience
6. Complex Combined VCA - Are We Ready?
7. Face Transplantation versus Conventional Reconstruction

Part IV - The Cutting Edge of Reconstructive Transplantation
8. Surgical Planning in Face Transplants - From Simulation to Execution
9. The Sensitized VCA Recipient - Regimens and Risks
10. Whole Eye Transplantation

Part V - Unique Considerations and Emerging Indications in Reconstructive Transplantation
11. Thyroid Transplantation - Indications and Challenges
12. Tracheal Transplantation - Lessons Learned and Current Progress
13. Penile Transplantation - The Ethics of VCA for Gender Affirmation REGENERATIVE SURGERY

Part VI - Graft Targeted Therapies
14. Local Graft Cellular Therapies for Immunomodulation in VCA
15. Biomaterials for Immune Regulation
16. Microneedles for Targeted Immunosuppressive Drug Delivery

Part VII - Cellular and Regenerative Therapies in Reconstructive Transplantation
17. Mixed Chimerism in Reconstructive Transplantation
18. Novel Senolytic Therapies - Translational Implications in VCA
19. Exosomal Therapies - Potential and Promise

Part VIII - Graft and Patient Monitoring in Reconstructive Transplantation
20. Nanoimaging and Nanotheranostics in Reconstructive Transplantation
21. Biomarker Surrogates for Graft Monitoring
22. Biosensors for Drug Monitoring

Part IX - Composite Tissue Graft Manipulation and Engineering
23. Composite Graft Engineering: Concepts and Challenges
24. Composite Graft Decellularization and Recellularization
25. Whole Graft Gene Editing Part X - Tissue Engineering of VCA Components
26. Bioengineered Scaffolds for VCA
27. Engineered Nervous Tissue Constructs for VCA
28. Thymic Engineering for VCA

Über Autor(innen)

Gorantla, Vijay
Dr. Gorantla is a tenured professor of surgery at Wake Forest University School of Medicine and the Wake Forest Institute for Regenerative Medicine. He is the director of the Vascularized Composite Allotransplantation (VCA) Program at Atrium Health Wake Forest Baptist. His research interests include biosensors and biosensing techniques, cellular therapies, nanomedicine, organ transplantations, reconstructive surgeries, regenerative medicine and its applications in transplantation and regenerative, pharmacology. Additionally, he studies the relationship between the immune system and the regenerative, oncogenic and autoimmune processes. Dr. Gorantla was a key member of the team that performed the nation's first hand transplant at the University of Louisville in 1999. He co-founded the first national society for VCA, the American Society for Reconstructive Transplantation (ASRT). Dr. Gorantla has authored more than 100 scientific papers and 15 book chapters in the field of VCA and is currently co-editing a comprehensive book on the subject of regenerative surgery.

Kulahci, Yalcin
Dr. Yalcin Kulahci is a Plastic and Reconstructive Surgeon with specific expertise in Reconstructive Surgery and Microsurgery. He is dual board-certified in Oral and Maxillofacial Surgery and Hand Surgery and was recruited as faculty in 2008 to the Gulhane Military Medical Academy (GMMA) in Istanbul, affiliated with NATO and USUHS. In 2011, Dr. Kulahci was appointed as an Associate Professor at the same institution. In 2012, he became a founding academic staff member for the Department of Hand and Upper Extremity Surgery in Ankara, Turkiye. In 2019, he was recruited to the Wake Forest Institute for Regenerative Medicine following 22 years of honorable service with the Military Health System in Turkey. Dr. Kulahci is currently a faculty member at the Wake Forest School of Medicine and has a comprehensive publication record in clinical reconstructive surgery and microsurgery, with decades of translational research experience in VCA.

Zor, Fatih
Dr. Zor is a Plastic and Reconstructive Surgeon with specific expertise in Reconstructive Surgery and Microsurgery. He served as assistant professor of Plastic Surgery and chief combat surgeon in Turkish Armed Forces for over 15 years. Dr. Zor established the first military VCA programs in Turkey and obtained approval for both hand and face transplantation in 2011. Given his field experience in battlefield medicine and expertise in complex reconstruction, tissue regeneration, and hand/face transplantation, he was recruited to Wake Forest Institute for Regenerative Medicine as a faculty in 2017. He participated on several collaborative multi-institutional RTRP and PRMRP awards in the area of reconstructive transplantation and tissue generation. Currently, he's working as Burn Surgery Fellow in Indiana University School of Medicine.

My research focus is on immunomodulation, non-invasive VCA monitoring, peripheral and optic nerve regeneration, nanomedicine applications involving transplant and tissue regeneration indications and multimodality imaging strategies for VCA.