Trauma Induced Coagulopathy

Softcover Nachdruck of the original 1. Auflage 2016
ISBN: 978-3-319-80322-7
Verlag: Springer International Publishing

Buch, Englisch, 601 Seiten, Previously published in hardcover, Format (B × H): 178 mm x 254 mm, Gewicht: 1177 g

This text is aimed at defining the current concepts that define trauma induced coagulopathy by critically analyzing the most up-to-date studies from a clinical and basic science perspective. It will serve as a reference source for any clinician interested in reviewing the pathophysiology, diagnosis, and management of the coagulopathic trauma patient, and the data that supports it. By meticulously describing the methodology of most traditional as well as state of the art coagulation assays the reader will have full understanding of the tests that are used to study trauma induced coagulopathy. The evolving use of blood products as well as recently introduced hemostatic medications are reviewed in detail.
Trauma Induced Coagulopathy will also be a valuable source for quick reference to the clinician that is faced with specific clinical challenges when managing coagulopathy.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Gonzalez, Eduardo

Moore, Ernest E.

Moore, Hunter B.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Hämatologie, Transfusionsmedizin
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Chirurgie Orthopädie- und Unfallchirurgie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete AINS Anästhesiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete AINS Intensivmedizin

Inhaltsverzeichnis

Cell-Mediated Hemostasis.- Antithrombin Contributions to Physiological Hemostasis and Thrombosis Prevention, and its Dysregulation in Trauma and TIC.- Physiology of Hemostasis: Plasmin-antiplasmin system.- Thrombin Formation.- Fibrinogen.- Activated Protein C.- Pathogenesis of Trauma Induced Coagulopathy: The Endothelium.- Platelets.- Fibrinolysis.- Neutrophils, Inflammation and Innate Immunity in Trauma-Induced Coagulopathy.- DAMPs: Damage-Associated Molecular Pattern Molecules in Hemostasis.- The Complement System and Coagulation.- Disseminated Intravascular Coagulation.- Prothrombin and Partial Thromboplastin Time.- Fibrinogen Assays.- Platelet Aggregometry.- Thrombelastography.- Rotational Thromboelastometry (ROTEM®).- Red Blood Cell: Manufacture, Storage, and Transfusion.- Plasma Transfusion.- Cryoprecipitate Transfusion.- The Evolving Role of Platelets in Trauma Care.- Massive Transfusion Protocols.- Fibrinogen and Clotting Factor Replacement.- Anti-Fibrinolytics.- Venous Thromboembolism.- Congenital and Acquired Hypercoagulable States.- Coagulopathy in Traumatic Brain Injury (TBI).- Liver Disease.- Hemostatic Abnormalities in Renal Disease.- Pediatrics.- Pregnancy.- Management of Chronically Anticoagulated Patients.- Animal Models.-

Über Autor(innen)

Ernest E. Moore, MD is Editor, Journal of Trauma and Acute Care Surgery (LWW)