Gonsalves / Halberstadt / Laurencin Biomedical Nanostructures

1. Auflage 2007
ISBN: 978-0-470-18582-7
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 450 Seiten, E-Book

Learn to Use Nanoscale Materials to Design Novel Biomedical Devicesand Applications
Discover how to take full advantage of nanoscale materials in thedesign and fabrication of leading-edge biomedical devices. Theauthors introduce you to a variety of possible clinicalapplications such as drug delivery, diagnostics, and cancertherapy. In addition, the authors explore the interface betweenmicron and nanoscale materials for the development of applicationssuch as tissue engineering. Finally, they examine the mechanisms ofcell interactions with material surfaces through the use ofnanotechnology-based material processing and characterizationmethods.
The text's three sections highlight its interdisciplinaryapproach:
* Part One: Nanostructure Fabrication
* Part Two: Bio-Nano Interfaces
* Part Three: Clinical Applications of Nanostructures
Among the key topics covered are nanotechnology in tissueregeneration; biomolecular engineering; receptor-ligandinteractions; cell-biomaterial interactions; nanomaterials indiagnostics, drug delivery, and cancer therapy; and nano- andmicron-level engineering and fabrication.
Throughout the text, clear examples guide you through the chemistryand the processing involved in designing and developing nanoscalematerials for biomedical devices. Each chapter begins with anintroduction and ends with a conclusion highlighting the keypoints. In addition, references at the end of the chapter help youexpand your research on any individual topic. In summary, this bookhelps biomedical researchers and engineers understand the physicalphenomena that occur at the nanoscale in order to design novelcell-based constructs for a wide range of applications.

Autoren/Hrsg.

Gonsalves, Kenneth

Gonsalves, Kenneth E.

Halberstadt, Craig

Halberstadt, Craig R.

Laurencin, Cato T.

Nair, Lakshmi

Nair, Lakshmi S.

Inhaltsverzeichnis

PART I. NANOSTRUCTURE FABRICATION.
1. Nanofabrication Techniques.
2. Micro/ Nano-Machining and Fabrication of Materials forBiomedical Applications.
3. Novel Nanostructures as Molecular Nanomotors.
4. Bioconjugation of Soft Nanomaterials.
5. Nanotechnology and Drug Delivery.
6. Polymeric NanoParticles and Nanopore Membranes for ControlledDrug and Gene Delivery .
7. Development of Nanostructures for Drug DeliveryApplications.
8. Bioconjugated Nanoparticles for Ultrasensitive Detection ofMolecular Biomarkers and Infectious Agents.
PART II. BIO-NANO INTERFACES.
9. ECM Interactions With Cells From The Meso To NanoScale.
10. Cell Behavior Towards Nanostructured Surfaces.
11. Cellular Behavior on Basement Membranes InspiredTopographically Patterned Synthetic Matrices.
12. Focal Adhesions: Self-Assembling Nanoscale MechanochemicalMachines that Control Cell Function.
13. Controlling Cell Behavior via DNA and RNA Transfections.
14. Multi-Scale Co-Culture Models for Orthopaedic InterfaceTissue Engineering.
PART III. CLINICAL APPLICATIONS OF NANOSTRUCTURES.
15. Nanostructures for Tissue Engineering/RegenerativeMedicine.
16. Nanostructures for Cancer Therapy.
17. Clinical Applications of Micro-and NanoScale Biosensors.
18. Nanoscale Iron Compounds Related to NeurodegenerativeDisorders.
19. Application of Nanotechnology into Life Science: Benefit orRisk.

Über Autor(innen)

Kenneth E. Gonsalves, PhD, is Distinguished Professor in the Department of Chemistry at the University of North Carolina at Charlotte. Dr. Gonsalves has more than fifteen years of experience in using photolithography and chemistry to develop materials that have features at both the micron and nanoscale. Working with Dr. Craig Halberstadt, he has successfully demonstrated the ability to create a new material that can be controlled at both these size scales to influence cell behavior. He has also developed active polymeric nanoparticles for delivery of antibiotics and genes. Craig R. Halberstadt, PhD, is Director of Tissue Engineering and Senior Research Scientist at the Cannon Research Center of Carolinas Medical Center. Dr. Halberstadt is a pioneer in the development of a scalable commercial process for the growth of a human skin product. He has also published extensively on cell/biomaterial interactions for cellular transplantation. Cato T. Laurencin, MD, PhD, is Lillian T. Pratt Distinguished Professor and Chair of the Department of Orthopaedic Surgery and Professor of Biomedical Engineering and Chemical Engineering at the University of Virginia. He has also been designated one of fifteen University Professors at the School. He has authored more than 250 peer-reviewed articles and has edited books in the areas of biomaterials, orthopaedic tissue engineering, and nanotechnology. He is the recipient of several national and international awards and was elected to the National Academy of Sciences, Institutes of Medicine. His current research interests include biomaterial synthesis, orthopaedic tissue engineering, gene therapy, drug delivery, and nanotechnology. Lakshmi S. Nair, MPhil, PhD, is Assistant Professor in the Department of Orthopaedic Surgery at the University of Virginia. She has authored more than fifty peer-reviewed articles in the areas of biomaterials, tissue engineering, drug delivery, and nanotechnology. Her research interests include hydrogels for tissue engineering and drug delivery, stimuli sensitive materials, and biomedical nanotechnology.