Gielen / Tiekink Metallotherapeutic Drugs and Metal-Based Diagnostic Agents

The Use of Metals in Medicine
1. Auflage 2005
ISBN: 978-0-470-86404-3
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 638 Seiten, E-Book

There are an astonishing number and variety of roles that metalsplay in contemporary medicine. This book contains information onthe medicinal uses of inorganics, that is, of elements such asboron, lithium, selenium, to name a few, as well asmetal-containing species.
In keeping with the notion that healthy mammals rely on(bio-essential) metals for the normal functioning of approximatelya third of their proteins and enzymes, a large number of drugs aremetal-based and considerable effort is being devoted to developingboth second- and third-generation drugs as well as generating novelmetal-based drugs. While there is no doubt that there is anemphasis on 'Metallotherapeutics' throughout the volume, the use ofmetals in medicine is not restricted to metal-based drugs. Thefollowing are also covered:
* non-invasive radiopharmaceuticals
* Magnetic Resonance Imaging (MRI)
* mineral supplements
From the foregoing and, more importantly, from the contents of thevarious Chapters, the reader will gain an appreciation of the veryreal role metal-based drugs play in modern medicine and of theconsiderable effort being devoted to the development of novelcomplexes with greater efficacy as therapeutic and diagnosticagents.

Autoren/Hrsg.

Gielen, Marcel

Tiekink, Edward R. T.

Inhaltsverzeichnis

List of Contributors.
Preface.
1. 3Li Lithium Metallotherapeutics (RobinS.B. Williams and Adrian J. Harwood).
2. 5B Boron Compounds as TherapeuticDrugs (Geeta Rana, Kamesh Vyakaranam, John A. Maguire and NarayanS. Hosmane).
3. 12Mg The Role of Magnesium as aMetallotherapeutic Drug (Pietro Delva).
4. 13Al Aluminum Metallotherapeutics(Thanos Salifoglou).
5. 14Si Biological Activity ofOrganosilicon Compounds (Edmunds Lukevics and Luba Ignatovich).
6. 20Ca The Role of Calcium as aMetallotherapeutic Drug (Mario Barbagallo and Ligia J.Dominguez).
7. 22Ti Anti-tumor Titanium Drugs (ErichDubler).
8. 23V Insulin-MimeticVanadium-Containing Compounds (Tamds Kiss and TamdsJakusch).
9. 25Mn Manganese Metallotherapeutics(Jeanne H. Freeland-Graves, Tanushree Bose and AbbassKarbassian).
10. 26Fe The Use of Iron-Based Drugs inMedicine (Xiang Wu and Mei Lin Go).
11. 27Co Cobalt Complexes as PotentialPharmaceutical Agents (Hui Chao and Liang-Nian Ji).
12. 29Cu Chemotherapeutic CopperCompounds (Francisco González-Vílchez andRosario Vilaplana).
13. 30Zn The Role of Zinc as aMetallotherapeutic Agent (Jane V. Higdon and Emily Ho).
14. 31Ga Therapeutic Gallium Compounds(Lawrence R. Bernstein).
15. 32Ge Biological Activity ofOrganogermanium Compounds (Edmunds Lukevics and LubaIgnatovich).
16. 33As Metallotherapeutic ArsenicCompounds (Paul C. Ho).
17. 34Se The Use of Selenium-Based Drugsin Medicine (Michael Carland and Tahli Fenner).
18. 43Tc Technetium in Medicine (OyebolaO. Sogbein and John F. Valliant).
19. 44Ru Perspectives of RutheniumComplexes in Cancer Therapy (Olivier Lentzen, CécileMoucheron and Andrée Kirsch-De Mesmaeker).
20. 45Rh Rhodium in Medicine (Florian P.Pruchnik).
21. 46Pd The Use of Palladium Complexesin Medicine (Achilleas Garoufis, Sotiris K. Hadjikakou and NickHadjiliadis).
22. 50Sn Tin Compounds and TheirTherapeutic Potential (Marcel Gielen and Edward R.T. Tiekink).
23. 51Sb Antimony in Medicine (SiucheongYan, Lan Jin and Hongzhe Sun).
24. 75Re Therapeutic RheniumRadiopharmaceuticals (Jonathan R. Dilworth and Paul S.Donnelly).
25. 78Pt Platinum-Based Drugs (ViktorBrabec and Jana Kasparkova).
26. 79Au Gold-Based Metallotherapeutics:Use and Potential (Soo Yei Ho and Edward R.T. Tiekink).
27. 83Bi Bismuth-Based Pharmaceuticals(Neil Burford and Melanie D. Eelman).
28. Paramagnetic Metal Complexes as Contrast Agents for MagneticResonance Imaging (Silvio Aime, Alessandro Barge, Eliana Gianolio,Simonetta Geninatti Crich, Walter Dastrù and FulvioUggeri).
Index.