Brain Targeted Drug Delivery Systems: A Focus on Nanotechnology and Nanoparticulates

Erscheinungsjahr 2018
ISBN: 978-0-12-814001-7
Verlag: ACADEMIC PR INC

Buch, Englisch, 499 Seiten, Format (B × H): 152 mm x 229 mm, Gewicht: 662 g

Brain Targeted Drug Delivery Systems: A Focus on Nanotechnology and Nanoparticulates provides a guide on nanoparticulates to both academic and industry researchers. The book discusses key points in the development of brain targeted drug delivery, summarizes available strategies, and considers the main problems and pitfalls evidenced in current studies on brain targeted drug delivery systems. As the brain is the most important organ in the human body, and disorders of the central nervous system (CNS) are the most serious threat to human life, this book highlights advances and new research in drug delivery methods to the brain.

Zielgruppe

<p>Pharmaceutical industry scientists, graduate students and academic researchers in pharmaceutical science and materials science working in drug delivery and nanotechnology, clinical researchers including neuroscientists and cancer researchers</p>

Autoren/Hrsg.

Gao, Huile

Gao, Xiaoling

Fachgebiete

• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Pharmazeutische Technologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Neuropharmakologie, Psychopharmakologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie

Inhaltsverzeichnis

1. Introduction and overview

Part I Physiology and principles for brain targeting drug delivery

2. Anatomy and physiology of blood-brain barrier

3. Recent progress in blood-brain barrier transportation research

4. In vitro and in vivo models of BBB to evaluate brain targeting drug delivery

Part II Nanoparticles-based brain targeting delivery strategies

5. Receptor-mediated transportation through BBB

6. Carrier-mediated transportation through BBB

7. Brain drug delivery by adsorption-mediated transcytosis

8. Efflux pump inhibition to enhance brain targeting delivery

9. Physically open BBB

10. Nanoparticle systems for nose-to-brain delivery

11. Brain local delivery strategy

Part III Nanoparticles-based brain targeting delivery for CNS disorder management

12.Glioma targeted delivery systems

13.Nanotherapeutic strategies for the treatment of neurodegenerative diseases

14. Savaging brain ischemia by increasing brain uptake of neuroprotectants

Part IV Perspective and pitfalls of nanoparticles-based brain targeting delivery

15. Neurotoxicity concern about the brain targeting delivery systems

16. The intra-brain distribution of brain targeting delivery systems

17. The elimination of brain-targeted nanomaterials

18. Perspective on brain targeting drug delivery systems

Über Autor(innen)

Gao, Xiaoling
Xiaoling Gao is a Professor at Department of Pharmacology and Chemical Biology, Shanghai Jiaotong University School of Medicine. Her research has been focused on developing novel nanomedicines and nanoparticulate drug delivery systems for the management of brain diseases, especially Alzheimer's disease and glioma. She has authored or co-authored more than 50 papers in peer-reviewed journals, which have been cited more than 1500 times. Her work has been highlighted in ACS Nano Perspective and reported by Chemical and Engineering News. She received the nomination award of China Top 100 Excellent Doctoral Dissertations in 2009, and won the 2nd prize for Progress in Science and Technology awarded by Chinese Pharmaceutical Association in 2010. As a main contributor, she also won the 1st Prize for Progress in Science and the 1st Prize for Progress in Technology, awarded by the Chinese Ministry of Education. In 2017, she won the Excellent Youth Award from the National Natural Science Foundation, and was enrolled in National Youth Talent Support Program.