Advancement of Phenolic Acids in Drug Discovery

Fundamentals and Applications
Erscheinungsjahr 2024
ISBN: 978-0-443-18538-0
Verlag: Elsevier Science Publishing Co Inc

Buch, Englisch, 538 Seiten, Format (B × H): 228 mm x 153 mm, Gewicht: 860 g

Advancement of Phenolic Acids in Drug Discovery: Fundamental and Applications offers comprehensive coverage of the ADMET profiles of phenolic acids, their extraction method and prospects for drug design and development. Chapters overview phenolic acids and their characterization, discuss the role of phenolic acids in plant systems, present sources and detailed extraction methods of phenolic acids, and cover phenolic acid mechanisms of action as it relates to several key diseases and health conditions, including their role as antioxidant agents, anti-inflammatory and analgesic drugs, anti-microbial drugs, anti-viral drugs, anti-cancer drugs, diabetes and metabolic dysfunctions, neurological disorders, cardiovascular diseases. The book's final chapters cover nanoscience aspects of phenolic acids, biomedical applications, and concludes with challenges and opportunities presented by phenolic acids. This is the ideal reference for researchers in the fields of drug development, both in academia and corporate settings. Researchers of related areas like food science and medicinal chemistry will also benefit from this in-depth profiling of therapeutical properties of phenolic acids.

Autoren/Hrsg.

Gandara, Jesus Simal

Kumar, Naresh

Goel, Nidhi

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer

Inhaltsverzeichnis

1. Phenolic acids: A Brief Overview
2. Sources and extraction methods of phenolic acids
3. Role of phenolic acids in plant system
4A. Antioxidant methods, in vitro and in vivo studies of phenolic acids
4B. Phenolic acids as potent antioxidant agents
5. Phenolic acids based anti-inflammatory and analgesic drugs
6. Progressive approach of phenolic acids towards the advancement of antimicrobial drugs
7. Promising role of phenolic acids as antimalarial and antiviral drugs
8. Development of phenolic acids-based system as anticancer drugs
9. Utility of phenolic acids in neurological disorders
10. Role of aronia`s phenolic acids in the treatment of diabetes mellitus
11. Phenolic acids in cardiovascular cure and treatment
12. Development of phenolic acids based nanocarriers and nanomedicines
13. Valorization of phenolic compounds delivery through lactic acid fermentation of fruit and vegetable juices: Innovations, challenges and gaps
14. Development of metal-phenolic acid network for biomedical usages
15. Grand challenges and opportunities for phenolic acids

Über Autor(innen)

Goel, Nidhi
Dr. Nidhi Goel received her doctorate in Chemistry, Indian Institute of Technology Roorkee, India. After postdoctoral research from Indian Institute of Science Bangalore, Karnataka, India, she started her independent academic career as Assistant Professor, Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi, India. Her research focuses on developing strategies, based on supramolecular building approaches, for rational construction of functional coordination polymers, Metal-Organic Frameworks and their prospective uses include magnetic, luminescence, and sensing applications. She is also working on drug design, medicinal chemistry natural products chemistry, and chemical biology. Dr. Goel has published more than fifty peer-reviewed research papers and book chapters in reputed international journals and books. She has 15 years research experience along with six years teaching experience at UG and PG level. She has been the Principal Investigator on three research projects from the Government of India. She is also a regular reviewer of a variety of international journals, and has also received several prestigious fellowships and research awards. Moreover, Dr. Goel is editing several books in CRC press Taylor & Francis group, Springer, and Elsevier. She is also acting as Guest Associate Editor in reputed journals.

Gandara, Jesus Simal
Jesus Simal-Gandara is Full Prof in Nutrition and Food Science at the Faculty of Food Science and Technology, University of Vigo (Spain). He is Corresponding Member of the Royal Academy of Medicine and Surgery of Galicia (1991), Member of the Scientific Committee of the Spanish Agency for Consumption, Food Safety and Nutrition (2013-2016), Research Medal of the Royal Galician Academy of Sciences 2020 Antonio Casares Rodriguez (Chemistry and Geology), President of the International Association of Dietary Nutrition and Safety (2020), Full Member of the Royal Academy of Pharmacy of Galicia (2021), and Associate Editor in Food Science and Nutrition (Wiley) and Food Chemistry (Elsevier). He leads a research group of excellence, and was leading CIA3 - Environmental, Agricultural and Food Research Center (2008-2018). He was the Head of the Department of Analytical Chemistry and Food Science (2013-2018), and Vice-Chancellor for Internationalization at the University of Vigo (2018).

Kumar, Naresh
Dr. Naresh Kumar has earned his master's and doctorate degrees in biotechnology from Himachal Pradesh University, Shimla and Indian Institute of Technology Roorkee, respectively. He has 6 years of postdoctoral experience at Indian Institute of Technology Roorkee and Indian Institute of Technology Indore. Dr. Kumar is currently working as an assistant professor at the Department of Biochemistry, Deshbandhu College, University of Delhi, Kalkaji, New Delhi, India. His current research focuses on natural products, chemical biology, computational biology, and drug discovery. With more than 12 years of research and 2 years of teaching experience, he is supervising several doctoral students. He contributed signi? cantly to 21 peer-reviewed publications (his citations: >2200, h-index: 13, i10: 16) in addition to several invited book chapters with reputed international publishers. Dr. Kumar is editing books for Elsevier, Springer Nature, and Bentham Science. He also regularly reviews scienti? c articles for a variety of international publishers. He has also received many prestigious fellowships and research awards.