Friedmann Molecular Genetic Medicine

Volume 1
1. Auflage 2013
ISBN: 978-1-4832-6205-5
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 254 Seiten, Web PDF

Molecular Genetic Medicine, Volume I, provides an overview of the progress in several of the most important areas of modern molecular genetics and medicine. The aim is to present a technical and historical picture of the concept that it is through a thorough understanding of genetics of all kinds of human diseases, even infectious diseases, that effective treatments will finally come. The book opens with a discussion of the origins and development of the Human Genome Project. This is followed by separate chapters on the development of immune-deficient mice as models for human hematopoietic disease; the application of genetic techniques for testing identity and relatedness of persons; and advances in recombinant DNA technology and their applications in drug discovery. The final chapter discusses the impact of molecular biology and molecular evolution on debates about the origin of humans, and about the origins both of the characteristics that they share with other animals and of those that make humans unique.

Autoren/Hrsg.

Friedmann, Theodore

Inhaltsverzeichnis

1;Front Cover;1
2;Molecular Genetic Medicine;4
3;Copyright Page;5
4;Table of Contents;6
5;Contributors;8
6;Foreword;10
7;Preface;12
8;Chapter 1. The Genesis of the Human Genome Project;14
8.1;I. INTRODUCTION;14
8.2;II. TECHNICAL AND SCIENTIFIC BACKGROUND;15
8.3;III. ORIGINS OF GENOME RESEARCH PROGRAMS;24
8.4;IV. CONCLUSIONS;80
8.5;Acknowledgments;82
8.6;References;82
9;Chapter 2. Immune-Deficient Mice as Models for Human Hematopoietic Disease;90
9.1;I. INTRODUCTION;90
9.2;II. HEMATOPOIESIS;91
9.3;III. GENETIC MANIPULATION OF HEMATOPOIETIC STEM CELLS;98
9.4;IV. ENGRAFTMENT OF HUMAN HEMATOPOIETIC CELLS IN IMMUNE-DEFICIENT MICE;103
9.5;V. APPLICATIONS;114
9.6;VI. SUMMARY;122
9.7;Acknowledgments;122
9.8;References;123
10;Chapter 3. An Application of DNA Sequencing to a Human Rights Problem;130
10.1;I. INTRODUCTION: THE HISTORICAL CONTEXT;130
10.2;II. THE CURRENT STATE OF THE ART OF HUMAN IDENTIFICATION USING GENETIC TECHNIQUES;132
10.3;III. SEQUENCING OF MITOCHONDRIAL DNA (MTDNA) AS A GENETIC SYSTEM FOR TESTING RELATIONSHIP;134
10.4;IV. DIVERSITY OF THE CONTROL REGION OF HUMAN MTDNA;136
10.5;V. ISOLATION OF MTDNA FROM VARIOUS HUMAN TISSUES;138
10.6;VI. TESTING RELATIONSHIPS IN ARGENTINA;139
10.7;Acknowledgments;142
10.8;References;142
11;Chapter 4. Molecular Genetics and Drug Discovery;146
11.1;I. INTRODUCTION;146
11.2;II. THERAPEUTICS PRODUCED BY RECOMBINANT DNA TECHNOLOGY;148
11.3;III. SITE-DIRECTED MUTAGENESIS;151
11.4;IV. GENETICALLY ENGINEERED DRUG DISCOVERY TOOLS;157
11.5;V. FUTURE PROSPECTS;169
11.6;Acknowledgments;171
11.7;References;171
12;Chapter 5. The Role of Molecular Biology in Human Evolutionary Studies: Current Status and Future Prospects;182
12.1;I. INTRODUCTION;182
12.2;II. THE UNIQUE FEATURES OF PRIMATE EVOLUTION;186
12.3;III. THE PRIMATE FAMILY TREES;189
12.4;IV. TWO EXTREME GENETIC MODELS FOR HUMAN ORIGINS AND EVOLUTION;194
12.5;V. HUMAN HISTORY AND THE GENETICS OF REGIONAL TRANSITION;199
12.6;VI. MITOCHONDRIA AND HUMAN EVOLUTION;202
12.7;VII. WILL IT BE POSSIBLE TO FIND A Y-CHROMOSOME ADAM?;217
12.8;VIII. THE EXTENT OF HUMAN DIVERSITY;219
12.9;IX. Conclusions;235
12.10;References;237
13;Index;246