Fraser / Martin / Tinsley Measles Virus and Its Biology

1. Auflage 2013
ISBN: 978-1-4832-7214-6
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 260 Seiten, Web PDF

Measles Virus and Its Biology deals with the biological and clinical problems of the viral disease, measles. This book also describes the behavior of the measles virus in terms of its immunological, biochemical, or molecular-biological aspects. The authors review the epidemiology and pathogenesis of measles and discuss how the virus flourishes and mobilizes in the human body through a close association with leukocytes and lymphoid organs. Biological characters and genetic markers of the virus can serve to separate different isolates of the measles virus from one another. Radioactive labeling techniques have detected six structural proteins associated with the virus; a schematic diagram in the book shows the structural components and the biochemical dissection of the virus. The authors also discuss that the various immune responses to the virus can be due to 'variation in the patient' rather than virus mutation. The authors do not discount that the physiological behavior of the virus such as its location, number, or replication can also affect the host. This text is suitable for the clinical research workers dealing with immunology, infectious diseases, cellular chemistry, or molecular biology.

Autoren/Hrsg.

Fraser, K. B.

Martin, S J

Tinsley, T. W.

Brown, F.

Inhaltsverzeichnis

1;Front Cover;1
2;Measles Virus and its Biology;6
3;Copyright Page;7
4;Table of Contents;10
5;PREFACE;8
6;Chapter 1. The biology of measles;12
6.1;THE EPIDEMIOLOGY OF MEASLES;14
6.2;THE PATHOGENESIS OF MEASLES;17
6.3;COMMENT;22
7;Chapter 2. The isolation and adaptation of measles virus;23
7.1;ISOLATION OF MEASLES VIRUS;24
7.2;ADAPTATION TO TISSUE CULTURE AND CHICK EMBRYO;25
7.3;ADAPTATION TO MAMMALIAN HOSTS;30
7.4;SSPE MEASLES VIRUSES;33
7.5;COMMENT;33
8;Chapter 3. Biological characters and genetic markers;36
8.1;HOST RANGE;37
8.2;CYTOPATHIC EFFECT;38
8.3;PATHOGENICITY AND VIRULENCE IN ANIMALS;40
8.4;PLAQUE FORMATION;40
8.5;HAEMAGGLUTINATION;41
8.6;TEMPERATURE-SENSITIVE MUTANTS;46
8.7;SSPE STRAINS;47
8.8;PHYSICAL PROPERTIES;48
8.9;MEASLES, CANINE DISTEMPER AND RINDERPEST VIRUSES;48
8.10;COMMENT;50
9;Chapter 4. Structure and components of measles virus;52
9.1;THE VIRION;52
9.2;NUCLEOCAPSID;55
9.3;VIRION RNA;57
9.4;STRUCTURAL POLYPEPTIDES;58
9.5;COMMENT;63
10;Chapter 5. Non-vegetative functions of measles virus, haemagglutination, haemolysis and cell-fusion;66
10.1;HAEMAGGLUTINATION;67
10.2;HAEMOLYSIS;70
10.3;CELL FUSION FROM WITHOUT THE CELL;73
10.4;COMMENT;76
11;Chapter 6. The growth cycle of measles virus;77
11.1;GENERAL FEATURES;78
11.2;THE ASSAY;79
11.3;ADSORPTION;84
11.4;PENETRATION;85
11.5;THE REPLICATIVE PROCESSES;85
11.6;MATURATION AND RELEASE OF MEASLES VIRUS;97
11.7;MORPHOGENESIS OF MEASLES VIRUS;100
12;Chapter 7. Persistent infection by measles virus;108
12.1;BIOLOGICAL ASPECTS OF PERSISTENT INFECTION;108
12.2;MOLECULAR ASPECTS OF PERSISTENT INFECTION;118
12.3;GENESIS OF PERSISTENT INFECTION;120
12.4;COMMENT—THE FEATURES OF PERSISTENT INFECTION;126
13;Chapter 8. Neuropathogenicity of measles virus;129
13.1;EXPERIMENTAL ENCEPHALITIS;130
13.2;THE EFFECT OF AGE OF THE HOST ON SUSCEPTIBILITY;134
13.3;PATHOGENESIS OF ENCEPHALITIS;135
13.4;SIGNIFICANCE OF FINDINGS;146
14;Chapter 9. Measles virus and subacute sclerosing panencephalitis— SSPE-viruses;149
14.1;ASSOCIATION BETWEEN MEASLES VIRUS AND SSPE;149
14.2;HOST RANGE AND VARIABILITY OF ISOLATES;157
14.3;SYNTHESIS OF VIRUS ANTIGEN;161
14.4;BIOCHEMICAL STUDIES ON SSPE VIRUSES;164
14.5;NEUROPATHOGENICITY;166
14.6;COMMENT;169
15;Chapter 10. Immunology of measles virus—epidemiology; specific antibodies;171
15.1;EPIDEMIOLOGY AND IMMUNITY;172
15.2;TESTS FOR ANTIBODY;173
15.3;APPEARANCE AND DURATION OF CIRCULATING ANTIBODY;174
15.4;CLASSES OF SPECIFIC IMMUNOGLOBULIN;177
15.5;ANTIBODY AND INFECTED CELLS;178
15.6;COMMENT;179
16;Chapter 11. Immunology of measles virus—cell-mediated immunity;181
16.1;CIRCULATING LEUKOCYTES AND MEASLES VIRUS;182
16.2;NON-SPECIFIC RESPONSES FOLLOWING MEASLES IN VIVO;183
16.3;NON-SPECIFIC RESPONSES FOLLOWING INFECTION IN VITRO;188
16.4;SPECIFIC RESPONSES TO MEASLES ANTIGEN;191
16.5;COMMENT;196
17;Chapter 12. Immunology of measles virus—multiple sclerosis and auto-immune diseases;198
17.1;MULTIPLE SCLEROSIS;198
17.2;SYSTEMIC LUPUS ERYTHEMATOSIS AND AUTO-IMMUNE STATES;205
17.3;COMMENT;207
18;Chapter 13. Immunology of measles virus—immunization; immunodeficient states;208
18.1;IMMUNIZATION;208
18.2;IMMUNODEFICIENCY AND IMMUNOSUPPRESSION;212
18.3;COMMENT;214
19;References;216
20;Subject Index;252