Buch, Englisch, 243 Seiten, Format (B × H): 152 mm x 229 mm, Gewicht: 376 g
Buch, Englisch, 243 Seiten, Format (B × H): 152 mm x 229 mm, Gewicht: 376 g
ISBN: 978-3-7091-9227-6
Verlag: Springer Vienna
The structure of eunicillin (89), a carbobicyclic diterpenoid isolated from the Mediterranean gorgonian Eunicella stricta, was reported in 1968 (1). At that time chlorine-containing diterpenoids had been dis covered in the gorgonian Briareum asbestinum (2, 3), but it was not until 1977 that the structure of the first briaran, briarein A (211), was resolved by X-ray analysis (4). The first trinervitane diterpenoid (26), which was isolated from Trinervitermes termites, was reported in 1976 (5). OAc OAc ACO'···· OH 0 89 211 26 The discovery of these compounds marked the appearance of a large and growing group of diterpenoids which are commonly viewed as being formed from cembrane precursors by secondary carbon-carbon bond closures. It should be emphasized, however, that in the absence of biosynthetic evidence the question of which groups of diterpenoids that should be classified as cyclized cembranoids remains ambiguous. In the present article we have included five tobacco diterpenoids (1-5) which. possess prerequisite structural features and co occur with appropriate cembrane precursors in tobacco. Although structurally reminiscent of cyclized cembranoids, verticillanes, taxanes and cleomeolide are not dealt with, since these diterpenoids of plant origin are not believed to arise via preformed cembranoids (6-11).
Zielgruppe
Research
Weitere Infos & Material
Cyclized Cembranoids of Natural Occurrence.- I. Introduction.- II. Cyclized Cembranoids from Tobacco.- III. Cyclized Cembranoids from Insects.- IV. Cyclized Cembranoids from Marine Invertebrates.- Addendum.- Acknowledgements.- References.- Chemical Synthesis of Heparin Fragments and Analogues.- 1. Introduction.- 2. Synthesis of the Antithrombin Binding Site.- 3. Synthesis and Biological Properties of Analogues of the Antithrombin Binding Site.- 4. Conformational Properties.- 5. Interaction of Heparin Pentasaccharide Fragments with Antithrombin III.- Acknowledgements.- References.- Author Index.- General Index Vol. 21–60.
