Fishburn / Linnell / Evans An Introduction to Pharmaceutical Formulation

The Commonwealth and International Library: Pharmacy and Pharmaceutical Chemistry
1. Auflage 2013
ISBN: 978-1-4831-3853-4
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 200 Seiten, Web PDF

An Introduction to Pharmaceutical Formulation describes the various forms in which drugs may be supplied to doctors, patients, and veterinary surgeons. An account is given of the materials which may be added to drugs in order to provide formulated products, and of the methods by which formulations are assessed. The book begins with a background on pharmaceutical formulation, describing manufactured and official formulations, important criteria for a formulation, and technical advances in pharmacy during the post-war period. This is followed by separate chapters on diluents, solvents, and liquid vehicles; thickeners and binders; the chemistry and pharmacology of surface-active agents; and colors, flavors, and preservatives. Subsequent chapters cover solid, liquid, and paste formulations; controlled drug release; the stability of formulations; the importance of the container of the formulation; and large-scale manufacturing of formulated products. This book is intended primarily for students of pharmacy. It is not a textbook of practical or theoretical pharmaceutics but should be read in conjunction with other books on these subjects.

Autoren/Hrsg.

Fishburn, A. G.

Linnell, W. H.

Evans, A. J.

Inhaltsverzeichnis

1;Front Cover;1
2;An Introduction to Pharmaceutical Formulation;4
3;Copyright Page;5
4;Table of Contents;6
5;FOREWORD;8
6;CHAPTER 1. BACKGROUND;10
6.1;The Manufactured Formulation;12
6.2;The Official Formulation;15
6.3;Some Important Criteria;16
6.4;Recent Advances;19
6.5;Recommended Further Reading;23
7;CHAPTER 2. DILUENTS, SOLVENTS AND LIQUID VEHICLES;24
7.1;Powder Diluents;26
7.2;Solvents and Liquid Vehicles;28
7.3;Group A: Water-miscible liquids;29
7.4;Group B: Water-immiscible liquids;34
7.5;Recommended Further Reading;38
8;CHAPTER 3. THICKENERS AND BINDERS; FATS AND WAXES;39
8.1;Thickeners and Binders;39
8.2;Group A: Organic;41
8.3;Group B: Inorganic;48
8.4;Fats and Waxes;50
8.5;Recommended Further Reading;56
9;CHAPTER 4. SURFACE-ACTIVE AGENTS;57
9.1;Chemistry;58
9.2;Pharmacology;59
10;CHAPTER 5. COLOURS, FLAVOURS AND PRESERVATIVES;70
10.1;Colours;70
10.2;Flavours;76
10.3;Preservatives;78
10.4;Recommended Further Reading;89
11;CHAPTER 6. SOLID FORMULATIONS;90
11.1;Group A: Bulk or Multidose;92
11.2;Effect of drug and process on formulation;109
11.3;Modifications to tablets;112
11.4;Pharmacopoeial control;117
11.5;Unofficial tests or standards;118
12;CHAPTER 7. LIQUID FORMULATIONS;126
12.1;Oral;127
12.2;Parenteral;131
12.3;Topical;138
12.4;Body Cavities;140
12.5;Recommended Further Reading;145
13;CHAPTER 8. PASTE FORMULATIONS;146
13.1;A. Non-emulsified;147
13.2;B. Emulsified Creams;151
13.3;Recommended Further Reading;154
14;CHAPTER 9. THE CONTROL OF DRUG RELEASE;155
14.1;The Need for Control;155
14.2;Methods of Control;157
14.3;Routes of Administration;160
14.4;Problems in the Development of a Controlled-release Formulation;164
14.5;Recommended Further Reading;166
15;CHAPTER 10. STABILITY;167
15.1;General;167
15.2;Types of Instability and their Effect;168
15.3;Stability Tests;170
15.4;Scheme of Testing;172
15.5;Stabilization;177
15.6;Assignment of Storage Life;178
15.7;Recommended Further Reading;178
16;CHAPTER 11. CONTAINERS;180
16.1;Protection of Contents;181
16.2;Convenience in Administration;184
16.3;Appearance and Identification;186
16.4;Pharmacopoeial Control;187
16.5;Recommended Further Reading;187
17;CHAPTER 12. PROCESS ESTABLISHMENT;188
17.1;Equipment;188
17.2;Rate of Output;195
17.3;Personnel;196
18;INDEX;200