IgE and Anti-IgE Therapy in Asthma and Allergic Disease

1. Auflage 2002
ISBN: 978-0-8247-0663-0
Verlag: CRC Press

Buch, Englisch, 576 Seiten, Format (B × H): 216 mm x 279 mm, Gewicht: 997 g

Reihe: Lung Biology in Health and Disease

Exploring the role of Immunoglobulin-E (IgE) in human disease, this reference summarizes current research on the mechanisms and utilization of anti-IgE therapeutics in the treatment of IgE-mediated allergic disease, inflammation, and asthma-discussing the structural composition of high- and low-affinity IgE receptors, the airway cells that express these receptors, and the functional activity of IgE-FceRI and IgE-FceRII interactions for improved control and management of allergic disorders.

Compiles previously unpublished data from the first extensive scientific investigations of Xolair!

IgE and Anti-IgE Therapy in Asthma and Allergic Disease
- reviews studies on the distribution of serum IgE levels of normal and asthmatic populations in developed regions of the world such as the United States, Canada, Scandinavia, New Zealand, and Europe

- offers novel methods for the design and formulation of monoclonal antibodies

- discusses the use of allergen bronchoprovocation to identify the characteristics and efficacy of new antiasthma and antiallergy medications

- examines the role of IgE in food and parasitic allergies
and covers

- the pathogenesis of atopic dermatitis and urticaria

- novel strategies to target mast cells and basophils

- murine models of allergic pulmonary inflammation

- the pathophysiology of allergic rhinitis
Supplemented with nearly 2000 contemporary references to facilitate further study, IgE and Anti-IgE Therapy in Asthma and Allergic Disease is an in-depth and timely source for basic and clinical immunologists; allergists; pulmonologists and pulmonary disease specialists; physiologists; molecular, cellular, and lung biologists; pediatricians; internists; and graduate and medical school students in these disciplines.

Zielgruppe

Professional Reference

Autoren/Hrsg.

Fick, Robert

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Physiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Pneumologie, Atmung, Asthma
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Allergologie

Inhaltsverzeichnis

Introduction

James D. Reimann, Sharon Safrin, and Robert B. Fick, Jr.

Understanding the Binding of IgE to Its High-Affinity Receptor and to an Anti-IgE Antibody
Leonard G. Presta and Robert L. Shields

Mediator Release from Basophils and Mast Cells and Its Relationship to FceRI Expression and IgE-Suppressing Therapies
Donald W. MacGlashan, Jr., John T. Schroeder, Lawrence M. Lichtenstein, Sarbjit S. Saini, and Bruce S. Bochner

Expression of IgE Receptors on Eosinophils
David Dombrowicz, André Capron, and Monique Capron

Eosinophil IgE Receptors: Controversy and Consensus
Hirohito Kita and Cheryl R. Adolphson

Murine Models of Asthma: Caveats and Conclusions on the Contribution of IgE and Mast Cells to Allergic Inflammation, Airway Hyperresponsiveness, and Airflow Obstruction
Jeffrey S. Tepper and Daniel B. Tumas

Role of IgE in Asthma: Pathogenesis and Novel Therapeutic Strategies
James Laurence Lordan, Stephen T. Holgate, and Ian Sayers

IgE-Mediated Response to Allergen in the Bronchoprovocation Laboratory
Louis-Philippe Boulet and Donald W. Cockcroft

Pathophysiology of the Airway Response to Inhaled Allergen in Asthmatic Subjects: Role of IgE
John V. Fahy

Efficacy and Safety of Xolair Anti-IgE Monoclonal Antibody in Adult Asthmatics
Robert B. Fick, Jr., and W. James Metzger

The Role of IgE in Pediatric Asthma
Henry Milgrom and Charles Johnson

Anti-inflammatory Activities of Omalizumab (Xolair), a Recombinant Humanized Monoclonal Antibody Binding IgE
Robert B. Fick, Jr.

Pulmonary Delivery of Anti-IgE: Rationale for Topical Delivery to the Airway
Theresa D. Sweeney, Melinda Marian, Jane Ruppel, and Jeanine L. Bussiere

Treatment of Seasonal Allergic Rhinitis
Thomas B. Casale and Patricia W. Rohane

Anti-IgE and Allergic Skin Diseases
Michaël F. Hofer and Donald Y. M. Leung

Role of IgE and Food Allergens
Ricki M. Helm and A. Wesley Burks

Role of IgE in Allergic Bronchopulmonary Aspergillosis
Priscilla S. A. Sarinas and Rajinder K. Chitkara

IgE and Its Role in Parasitic Helminth Infection: Implications for Anti-IgE-Based Therapies
Philip J. Cooper and Thomas B. Nutman

The Rise of Antibodies as Therapeutics
Maureen P. Quan and Paul Carter

Author Index

Über Autor(innen)

Robert Fick