Everitt / Wessely Clinical Trials in Psychiatry

2. Auflage 2008
ISBN: 978-0-470-72384-5
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 248 Seiten, E-Book

At last - a new edition of the highly acclaimed bookClinical Trials in Psychiatry
This book provides a concise but thorough overview of clinicaltrials in psychiatry, invaluable to those seeking solutions tonumerous problems relating to design, methodology and analysis ofsuch trials. Practical examples and applications are used toground theory whenever possible. The Second Edition includes newinformation regarding:
* Recent important psychiatric trials
* More specific discussion of psychiatry in the USA and theparticular problems of trials in the USA, including comments aboutthe FDA (U.S. Food and Drug Administration)
* An extended chapter on meta-analysis
* Further discussion of sub-group analysis
Special features include appendices outlining how to design andreport clinical trials, what websites and software programs areappropriate and an extensive reference section.
From the reviews of the First Edition:
"Everitt & Wessely are to be congratulated onproducing an excellent guide to help overcome the snags in clinicaltrial research. Clearly written and in an engrossing style, thebook is likely to become a classic textbook on clinical trials, andnot just in psychiatry. The authors' enthusiasm and grasp ofclinical trial research make for a gripping and insightfulread...it is one of the very best books that has been writtenon clinical trials." THE BRITISH JOURNAL OFPSYCHIATRY
"The experience of both authors in this area gives the book avery pragmatic approach grounded in reality, with theoreticaloverviews invariably being followed by practical examples andapplications... an invaluable companion to anyone involved in,or contemplating undertaking, clinical trials research."PSYCHOLOGICAL MEDICINE

Autoren/Hrsg.

Everitt, Brian S.

Wessely, Simon

Inhaltsverzeichnis

Preface to the first edition.
Preface to the second edition.
1. Treatments, good, bad or worthless - and how do wetell?
1.1 Treatments worthless - and worse.
1.2 A brief history of treating the mentally ill.
1.3 Summary.
2. The randomized clinical trial.
2.1 Introduction.
2.2 The clinical trial.
2.3 Ethical issues in clinical trials.
2.4 Informed consent.
2.5 Compliance.
2.6 Summary.
3. Design issues in clinical trials.
3.1 Introduction.
3.2 Clinical trial designs.
3.3 Methods of randomization.
3.4 Methods of masking treatments.
3.5 The size of a clinical trial.
3.6 Interim analysis.
3.7 Summary.
4. Special problems of trials in psychiatry.
4.1 Introduction.
4.2 Explanatory versus pragmatic trials.
4.3 Complex interventions.
4.4 Outcome measures in psychiatry.
4.5 Summary.
5. Some statistical issues in the analysis of psychiatrictrials.
5.1 Introduction.
5.2 P-values and confidence intervals.
5.3 Using baseline data.
5.4 Longitudinal data.
5.5 Missing values and dropouts in longitudinal data.
5.6 Multiple outcome measures.
5.7 Intention-to-treat.
5.8 Economic evaluation of trials.
5.9 Number needed to treat.
6. Analysing data from a psychiatric trial: anexample.
6.1 Introduction.
6.2 Beating the Blues.
6.3 Analysis of the post-treatment BDI scores.
6.4 Graphical displays and summary measure analysis oflongitudinal data.
6.5 Random effects models for the BtB data.
6.6 The dropout problem in the BtB data.
6.7 Summary.
7. Systematic reviews and meta-analysis.
7.1 Introduction.
7.2 Study selection.
7.3 Publication bias.
7.4 The statistics of meta-analysis.
7.5 Some examples of meta-analysis of psychiatric trials.
7.6 Summary.
8. RCTs in psychiatry: threats, challenges and thefuture.
8.1 Introduction.
8.2 Can randomized clinical trials in psychiatry bejustified?
8.3 Are randomized clinical trials really necessary?
8.4 Conflicts of interest.
8.5 Scandals, trials and tribulations.
8.6 The future of psychiatric trials.
8.7 Defending the clinical trial.
8.8 Summary.
Appendix A. Issues in the management of clinicaltrials- 'how to do it'.
A.1 Introduction.
A.2 Clinical trial protocols.
A.3 Getting the costs right.
A.4 Collecting and managing the data.
A.5 Writing the patient information sheet.
A.6 Getting informed consent.
A.7 Maintaining recruitment.
A.8 Useful web sites.
Appendix B. Writing a trial report.
B.1 Introduction.
Appendix C. Useful software for clinical trials.
C.1 Introduction.
C.2 Data management.
C.3Design.
C.4 Analysis.
Bibliography.
Index.

Über Autor(innen)

Brian S. Everitt. Professor of Behavioural Statistics,Department of Biostatistics and Computing, Institute of Psychiatry,King's College, London, UK.
Simon Wessely. Professor of Epidemiological andLiaison Psychiatry Director, King's Centre for Military HealthResearch, Institute of Psychiatry, King's College, London,UK; Department of Psychological Medicine, Weston EducationCentre, London, UK.