Oxidative Stress in Mitochondria Disorders of Aging

Mitochondria in Disease States. Special Topic Issue: Biological Signals and Receptors 2001, Vol. 10, No. 3-4
Erscheinungsjahr 2001
ISBN: 978-3-8055-7236-1
Verlag: S.Karger

Buch, Englisch, 142 Seiten, Gewicht: 340 g

Neurons are particularly vulnerable to age-associated decline in mitochondrial function due to their high energy demand. Thus, several models are proposed implicating mtDNA damage and mutation, and subsequent mitochondrial dysfunction, as an underlying factor in a substantial number of human pathologies including aging, neurodegenerative and neuromuscular diseases, and ischemia-reperfusion injury. Furthermore, the results of clinical, biochemical and molecular biology studies suggest that defective mitochondria contribute to neurodegenerative diseases in humans. For example, Friedreich’s ataxia exhibits mitochondrial iron overload, Huntington’s disease is characterized by defects in mitochondrial oxidative phosphorylation and aconitase deficiency, Parkinson’s disease is associated with a deficiency in mitochondrial complex I activity, and Alzheimer’s disease exhibits cytochrome oxidase deficiency. Neurologists, psychiatrists and biochemists will profit most from this special issue.

Autoren/Hrsg.

Ebadi, M.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Geriatrie, Gerontologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pathologie, Cytopathologie, Histopathologie