Heteroaromatic Lipoxin A4 Analogues

Synthesis and Biological Evaluation
2012
ISBN: 978-3-642-43892-9
Verlag: Springer

Buch, Englisch, 130 Seiten, Paperback, Format (B × H): 155 mm x 235 mm, Gewicht: 242 g

Reihe: Springer Theses

In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in  the synthesis of further heteroaromatic analogues for biological evaluation.

Zielgruppe

Research

Autoren/Hrsg.

Duffy, Colm

Fachgebiete

• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Naturwissenschaften Chemie Organische Chemie Biochemie

Inhaltsverzeichnis

Introduction.- Recent advances in the chemistry and biology of stable synthetic Lipoxin analogues.- Synthesis of Heck coupling partner for the preparation of heteroaromatic Lipoxin A4 analogues.- Synthesis and biological evaluation of pyridine-containing Lipoxin A4 analogues.- Thiophene-containing Lipoxin A4 analogues: synthesis and their effect on the production of key cytokines.- Towards the synthesis of various heteroaromatic Lipoxin A4 analogues.