Buch, Englisch, Band 2014,38, 178 Seiten, PB, Format (B × H): 148 mm x 210 mm, Gewicht: 267 g
Reihe: Schriftenreihe des Lehrstuhls Lebensmittel pflanzlicher Herkunft
Buch, Englisch, Band 2014,38, 178 Seiten, PB, Format (B × H): 148 mm x 210 mm, Gewicht: 267 g
Reihe: Schriftenreihe des Lehrstuhls Lebensmittel pflanzlicher Herkunft
ISBN: 978-3-8440-3347-2
Verlag: Shaker
The plants Hamamelis virginiana L. and Helleborus niger L. are both used for pharmaceutical purposes with a long traditional use in folk medicine. Surprisingly, up to date, the constituents of these plants are only poorly characterized. In complementary medicine, fermented extracts prepared from H. virginiana and H. niger according to the German Homoeopathic Pharmacopoeia (GHP) are used for pharmaceutical purposes, but the knowledge about the influence of the fermentation process on their secondary metabolites is mostly unknown.
Therefore, the intention of the recent thesis was a detailed analytical study to uncover the corresponding secondary metabolite spectra of H. virginiana leaves and in the aerial parts as well as the roots from H. niger. Furthermore, the conversion of these constituents was monitored for 6 months during processing according to the GHP. By HPLC-DAD and LC-MSn, the secondary metabolites in H. virginiana were identified as 27 phenolic compounds of the groups hydroxycinnamic acid derivatives, flavonol glycosides and tannins. During fermentation of H. virginiana leaf extracts, hydroxycinnamic acids remained stable. The flavonol glycosides and gallotannins were both transformed to low molecular weight substances. The secondary metabolites of H niger leaves were 15 acylated flavonol glycosides, ranunculin derivatives, beta-ecdysone and 19 steroidal sapoinins. The roots contained two subgroups of altogether 38 steroidal saponins: diosgenyl-type saponins and acetylated polyhydroxysaponins. During fermentation diosgenyl-type saponins were successively deglycosylated. The acetylated polyhydroxysaponins lost their acetyl groups, but were further cleaved only in parts.
Duckstein
Hamamelis virginiana L. and Helleborus niger L. – Characterization of their genuine constituent profiles and fermented extracts by high-performance liquid chromatography-tandem mass spectrometry (LC-MSn) jetzt bestellen!
Therefore, the intention of the recent thesis was a detailed analytical study to uncover the corresponding secondary metabolite spectra of H. virginiana leaves and in the aerial parts as well as the roots from H. niger. Furthermore, the conversion of these constituents was monitored for 6 months during processing according to the GHP. By HPLC-DAD and LC-MSn, the secondary metabolites in H. virginiana were identified as 27 phenolic compounds of the groups hydroxycinnamic acid derivatives, flavonol glycosides and tannins. During fermentation of H. virginiana leaf extracts, hydroxycinnamic acids remained stable. The flavonol glycosides and gallotannins were both transformed to low molecular weight substances. The secondary metabolites of H niger leaves were 15 acylated flavonol glycosides, ranunculin derivatives, beta-ecdysone and 19 steroidal sapoinins. The roots contained two subgroups of altogether 38 steroidal saponins: diosgenyl-type saponins and acetylated polyhydroxysaponins. During fermentation diosgenyl-type saponins were successively deglycosylated. The acetylated polyhydroxysaponins lost their acetyl groups, but were further cleaved only in parts.
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