Harnessing Endogenous Mechanisms for Targeted Drug Delivery

Erscheinungsjahr 2025
ISBN: 978-0-443-27429-9
Verlag: Elsevier Science

Buch, Englisch, 550 Seiten, Format (B × H): 191 mm x 235 mm

Harnessing Endogenous Mechanisms for Targeted Drug Delivery explores the cutting-edge advancements in the world of targeted drug delivery leveraging human biological mechanisms. This essential guide addresses the urgent need to enhance the efficiency of drug delivery and foster safe and effective therapies, particularly for biological agents like proteins, peptides, and nucleic acid molecules. The book offers a comprehensive exploration of tissue- and cell-specific delivery methods, emphasizing endogenous or biological techniques that can be utilized to improve drug delivery. It identifies the challenges associated with delivering complex molecules and accessing hard-to-reach sites, and provides practical solutions through endogenous strategies. Topics such as exploiting disease-specific stimuli to enhance delivery efficiency, the role of plasma proteins in drug delivery, and the utilization of extracellular vesicles to boost delivery efficiency are presented. Harnessing Endogenous Mechanisms for Targeted Drug Delivery emphasizes the clinical and commercial translation of these techniques, making this book an ideal resource for researchers, clinicians, and anyone interested in the future of drug delivery.

Autoren/Hrsg.

D'Souza, Anisha A

Milane, Lara Scheherazade

Amiji, Mansoor M.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Wirtschaftswissenschaften Wirtschaftssektoren & Branchen Fertigungsindustrie

Inhaltsverzeichnis

Section 1: Drug Delivery Challenges and Opportunities
1. Contemporary Drug Delivery Challenges
2. Delivery Barriers
3. Strategies for Targeted Drug Delivery

Section 2: Endogenous Strategies
4. Stimuli-Responsive Delivery
5. Glyco-Targeting using Lectins
6. Delivery using Plasma Proteins or Endogenous Peptides
7. Utilizing Virus Engineering in Drug Delivery
8. Living or artificial Cells as Trojan Horse-Cloaking Particles
9. Augmenting Cellular Cargo Capacity
10. Cell- and Bacterial-Derived Extracellular Vesicles-Based Targeted Delivery
11. Nucleic acid based delivery systems

Section 3: Clinical Translation
13. Challenges Associated with Endogenous Targeting - Preclinical to clinical, scalability, toxicity
14. Current Clinical Trials
15. Clinical and Commercial Translational Challenges

Über Autor(innen)

Amiji, Mansoor M.
Mansoor M. Amiji is the Distinguished Professor and Chairman of the Department of Pharmaceutical Sciences at the Bouvé College of Health Sciences at Northeastern University. Dr. Amiji has edited a number of books and is a frequently published author. His research focuses on the synthesis of novel polymeric materials for medical and pharmaceutical applications, drug delivery systems and nanomedical technologies, and his contributions in research advising, grant reviews for various organizations and editorial work for journals are invaluable.

Milane, Lara Scheherazade
Dr. Lara Milane is Assistant Teaching Professor in Biotechnology at the Bouvé College of Health Sciences at Northeastern University. She is interested in Mitochondrial Medicine. She is working on developing nanomedicines for a range of diseases (cancer, neurodegenerative disease, aging) that manipulate mitochondria for therapeutic outcomes. Dr. Milane was trained as a National Cancer Institute/ National Science Foundation Nanomedicine Fellow at Northeastern University, Boston, MA. Dr. Milane is an intuitive cancer biologist with research interests in developing translational nanomedicines that exploit the hallmarks of cancer.