In Quest of Tomorrow's Medicines

Softcover Nachdruck of the original 1. Auflage 1999
ISBN: 978-0-387-95542-1
Verlag: Springer

Buch, Englisch, 272 Seiten, Format (B × H): 155 mm x 235 mm, Gewicht: 429 g

An eminent scientist talks about the pharmaceutical industry, biotechnology and the future of drug research. In the course of our busy, technologically-driven lives, it is taken for granted that we respond to minor fluctuations in our health by taking pills – pills for headache and for toothache; sleeping pills and tranquilizers; pills to lower fever, quiet coughs, and clear the sinuses; medicines to reduce appetite; preparations to relieve heartburn; and many more. In the war against serious disease, medicines are an indispensable weapon in the physician's arsenal: they save lives, or at least prolong them and make them more bearable. Despite the important role that pharmaceuticals play in our lives, few of us know where medicines come from or how the pharmaceutical industry discovers and develops new drugs. Jürgen Drews, an acclaimed leader in the pharmaceutical industry, tells the fascinating story of drug discovery and development from his years of successfully leading international research teams at Hoffman-LaRoche. Drews traces the history of modern drug development from pharmacies, chemical companies, and individual entrepreneurs in Switzerland, Germany and the U.S. to the mega-corporations that dot the landscape of Europe, Japan and America. He describes the process by which new drugs are tested and brought to market, including a provocative look at how AIDS activism stimulated the approval process in the U.S. Drews' commentary on the role of clinical trials – the time involved and their cost – is sobering testimony to the complexity of bringing innovation to the marketplace. In the final two chapters of "In Quest of Tomorrow's Medicines", Drews offers an important and critical analysis of research in the pharmaceutical industry, pointing to strategies that work and management practices that impede progress.

Zielgruppe

Research

Autoren/Hrsg.

Drews, Jürgen

Weitere Mitwirkende

Kramer, D.

Fachgebiete

• Naturwissenschaften Physik Angewandte Physik Biophysik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Pharmazeutische Technologie
• Naturwissenschaften Biowissenschaften Angewandte Biologie Biophysik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Geschichte der Medizin
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien

Inhaltsverzeichnis

Drugs, Patients and the Pharmaceutical Industry: The Role of Drugs in the Practice of Medicine; The Role of the Pharmaceutical Industry in the Medical Use of Drugs.- THE HISTORY OF THE PHARMACEUTICAL INDUSTRY: The Development of the Pharmaceutical Industry; Natural Substances as Drugs.- DRUG RESEARCH MERGING EXPERIMENTAL PHARMACOLOGY AND CHEMISTRY: The Origins of Heterocyclic Chemistry; Dyes as Drugs: The Birth of Chemotherapy.- TECHNOLOGICAL ADVANCES AND A PARADIGM SHIFT IN DRUG RESEARCH: Technological Advance – Positive Crises; The Influence of Molecular Biology on Medicine.- A MEDICINE IS BORN – RESEARCH, DEVELOPMENT AND REGISTRATION: Research Strategies; What is Development? Requirements for Drug Approval and Safety; Development as Process.- MANAGEMENT OF INNOVATION: DIRECTING RESEARCH AND DEVELOPMENT: Two Cultures; Management of Research.- THE FUTURE OF RESEARCH AND DEVELOPMENT IN THE PHARMACEUTICAL INDUSTRY: Strategic Options; Focus of Innovation: The Biotechnology Industry; Centers of Innovation in the University; Future Pharmaceuticals Scenarios; Connections Between Basic Research and Pharmaceutical Innovation.