Buch, Englisch, 1146 Seiten, Format (B × H): 160 mm x 241 mm, Gewicht: 1859 g
Buch, Englisch, 1146 Seiten, Format (B × H): 160 mm x 241 mm, Gewicht: 1859 g
ISBN: 978-1-4614-1399-8
Verlag: Springer Us
This volume covers all aspects of the antibiotic discovery and development process through Phase II/III. The contributors, a group of highly experienced individuals in both academics and industry, include chapters on the need for new antibiotic compounds, strategies for screening for new antibiotics, sources of novel synthetic and natural antibiotics, discovery phases of lead development and optimization, and candidate compound nominations into development. Beyond discovery, the handbook will cover all of the studies to prepare for IND submission: Phase I (safety and dose ranging), progression to Phase II (efficacy), and Phase III (capturing desired initial indications). This book walks the reader through all aspects of the process, which has never been done before in a single reference. With the rise of antibiotic resistance and the increasing view that a crisis may be looming in infectious diseases, there are strong signs of renewed emphasis in antibiotic research. The purpose of the handbook is to offer a detailed overview of all aspects of the problem posed by antibiotic discovery and development.
Zielgruppe
Professional/practitioner
Autoren/Hrsg.
Fachgebiete
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
- Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Medizinische Mikrobiologie & Virologie
Weitere Infos & Material
Introductory History of Antimicrobial Drugs.- Marketed Major Classes of Compounds.- The Rise of Antibiotic Resistance/Resistance Mechanisms to Major Classes.- Clinical Issues of Resistance: “Worst Offenders” List of Problematic Microbes.- Antibiotic Discovery.- Antibiotic Drug Development.- The Economics and Incentives of Antibiotic Drug Discovery.
