Applied Organic Chemistry

Reaction Mechanisms and Experimental Procedures in Medicinal Chemistry
1. Auflage 2020
ISBN: 978-3-527-34785-8
Verlag: WILEY-VCH

Buch, Englisch, 758 Seiten, Format (B × H): 168 mm x 252 mm, Gewicht: 1882 g

An indispensable guide for all synthetic chemists who want to learn about the most relevant reactions and reagents employed to synthesize important heterocycles and drugs!

The synthesis of natural products, bioactive compounds, pharmaceuticals, and drugs is of fundamental interest in modern organic chemistry. New reagents and reaction methods towards these molecules are being constantly developed. By understanding the mechanisms involved and scope and limitations of each reaction applied, organic chemists can further improve existing reaction protocols and develop novel efficient synthetic routes towards frequently used drugs, such as Aspirin or Penicillin.

Applied Organic Chemistry provides a summary of important (name) reactions and reagents applied in modern organic chemistry and drug synthesis. It covers rearrangement, condensation, olefination, metathesis, aromatic electrophilic substitutions, Pd-catalyzed C-C bond forming reactions, multi-component reactions, as well as oxidations and reductions. Each chapter is clearly structured, providing valuable information on reaction details, step-by-step mechanism, experimental procedures, applications, and (patent) references. By providing mechanistic information and representative experimental procedures, this book is an indispensable guide for researchers and professionals in organic chemistry, natural product synthesis, pharmaceutical, and medicinal chemistry, as well as post-graduates preparing themselves for a job in the pharmaceutical industry.
- Hot Topic: Reviews important classes of organic reactions (incl. name reactions) and reagents in medicinal chemistry.
- Useful: Provides information on reaction details, common reagents, and functional group transformations used to synthesize natural products, bioactive compounds, drugs, and pharmaceuticals, e.g. Aspirin, Penicillin.
- Unique: For every reaction the mechanism is explained step by step, and representative experimental procedures are given, unlike most books in this area.
- User-friendly: Chapters are clearly structured making it easy for the reader to compare different reactions.

Applied Organic Chemistry is an indispensable guide for researchers and professionals in organic chemistry, natural product synthesis, pharmaceutical, and medicinal chemistry, as well as post-graduates preparing themselves for a job in the pharmaceutical industry.

Autoren/Hrsg.

De, Surya K.

Fachgebiete

• Naturwissenschaften Chemie Organische Chemie
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Verfahrenstechnik, Chemieingenieurwesen
• Naturwissenschaften Chemie Physikalische Chemie Chemische Reaktionen, Katalyse

Inhaltsverzeichnis

Preface
1) Rearrangement Reactions
2) Condensation Reactions
3) Olefination, Metathesis, and Epoxidation Reactions
4) Miscellaneous Reactions
5) Aromatic Electrophilic Substitution Reactions
6) Pd-catalyzed C-C bond Forming Reactions
7) Multi-component Reactions
8) Oxidations and Reductions
9) Nomenclature and Application of Heterocyclic Compounds
10) Synthesis of Heterocyclic Compounds using Name Reactions
11) Protection and Deprotection of Common Functional Groups
12) Amino Acids and Peptides
13) Functional Group Transformation
14) Synthesis of Some Drug Molecules
15) Common Laboratory Methods
16) Use of Common Reagents in Organic Synthesis
 

Über Autor(innen)

Surya K. De is the director at Supra Sciences, prior to this role, he was a principal scientist at Plex Pharmaceuticals and Collidion Inc. in San Diego, California (USA). He obtained his Ph.D. in Organic Chemistry from Jadavpur University, Kolkata (India). His research interests focus on the development of new synthetic methodology in organic synthesis (e.g. multi-step reactions), catalyst development, drug design and discovery, as well as medicinal chemistry. He has authored more than 100 peer reviewed international journal contributions, fifteen patents, and one book. He is an Editorial board member of Current Organic Synthesis, Letters in Organic Chemistry, Current Catalysis, Anti-Cancer Agents in Medicinal Chemistry. He has been an elected fellow of the Royal Society of Chemistry (UK) and an Alternate Councilor in the American Chemical Society (San Diego section).