Díaz Lantada Microsystems for Enhanced Control of Cell Behavior

Fundamentals, Design and Manufacturing Strategies, Applications and Challenges
1. Auflage 2016
ISBN: 978-3-319-29328-8
Verlag: Springer International Publishing
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band 18, 457 Seiten, eBook

Reihe: Studies in Mechanobiology, Tissue Engineering and Biomaterials

This handbook focuses on the entire development process of biomedical microsystems that promote special interactions with cells. Fundamentals of cell biology and mechanobiology are described as necessary preparatory input for design tasks. Advanced design, simulation, and micro/nanomanufacturing resources, whose combined use enables the development of biomedical microsystems capable of interacting at a cellular level, are covered in depth. A detailed series of chapters is then devoted to applications based on microsystems that offer enhanced cellular control, including microfluidic devices for diagnosis and therapy, cell-based sensors and actuators (smart biodevices), microstructured prostheses for improvement of biocompatibility, microstructured and microtextured cell culture matrices for promotion of cell growth and differentiation, electrophoretic microsystems for study of cell mechanics, microstructured and microtextured biodevices for study of cell adhesion and dynamics, and biomimetic microsystems (including organs-on-chips), among others. Challenges relating to the development of reliable in vitro biomimetic microsystems, the design and manufacture of complex geometries, and biofabrication are also discussed.

Zielgruppe

Research

Autoren/Hrsg.

Díaz Lantada, Andrés

Inhaltsverzeichnis

Some introductory notes
to cell behavior.- Brief introduction to the field of biomedical microsystems.- Brief
introduction to bio-microsystems for interacting with cells.- Common bioengineering resources for interacting with cells.- Methodologies
for the development of bio-microsystems.- Addressing the complexity of
biomaterials by biomimetic CAD.- Multi-scale and
multi-physical/biochemical modeling in bio-MEMS.- Rapid prototyping of
bio-MEMS for interacting with cells.- Nanomanufacturing for biomedical
MEMS.- Issues linked to the mass-production of biomedical microsystems.- Biomedical
microsystems for disease management.- Overview of microsystems for
studying cell behavior under culture.- Microsystems for
studying cell adhesion, dynamics and and overall
mechanobiology.- Smart microsystems for active cell culture
toward relevant tissues.- Tissue engineering scaffolds for 3D cell
culture.- Tissue engineering scaffolds for bone repair: General aspects.- Tissue
engineering scaffolds for bone repair: Dental repair.- Tissue engineering
scaffolds for repairing soft tissues.- Tissue engineering scaffolds for
osteochondral repair.- From labs-on-chips to microfluidic cell culture.- Cell-based
sensors and cell-based actuators.- Towards reliable organs-on-chips and
humans-on-chips.- Towards effective and efficient biofabrication
technologies.- Project-based learning in the field of biomedical
microsystems.- Annexes.

Über Autor(innen)

Andrés Díaz Lantada is Associate Professor at Technical University of Madrid (UPM), Spain, teaching 'Design and manufacture with polymers', 'Computer-aided engineering', and 'Bioengineering. He carries out research at the UPM Product Development Laboratory linked to the development of biomedical devices based on smart/multifunctional materials, biomimetic fractal and non-Euclidean designs, and mechanical metamaterials for enhanced performance and adequate tissue interaction.