Current Topics in Developmental Biology

1. Auflage 2004
ISBN: 978-0-08-049437-1
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 280 Seiten, Web PDF

Current Topics in Developmental Biology provides a comprehensive survey of the major topics in the field of developmental biology. The volumes are valuable to researchers in animal and plant development, as well as to students and professionals who want an introduction to cellular and molecular mechanisms of development. The series has recently passed its 30-year mark, making it the longest-running forum for contemporary issues in developmental biology.
This volume contains nine important contributions from leading minds in developmental biology.
* Presents major contemporary issues and astonishing discoveries at the forefront of modern developmental biology, stem cells, cloning, and regenerative medicine
* Series Editor Gerald Schatten is one of the leading minds in reproductive and developmental science
* The longest-running forum for current issues in developmental biology with over 30 years of coverage

Autoren/Hrsg.

Inhaltsverzeichnis

1;Cover ;1
2;Contents;6
3;Contributors;10
4;Preface;12
5;Chapter 1. Stem/Progenitor Cells in Lung Morphogenesis, Repair, and Regeneration;14
5.1;I. Introduction;14
5.2;II. Background;16
5.3;III. Symposium Presentations and Discussion;20
5.4;IV. Summary and Conclusions;23
5.5;References;24
6;Chapter 2. Lessons from a Canine Model of Compensatory Lung Growth;30
6.1;I. Structure–Function Considerations during Compensation;31
6.2;II. Dysanaptic Lung Growth;36
6.3;III. Signals for Compensatory Lung Growth;39
6.4;IV. Application to Human Lung Growth;42
6.5;Acknowledgments;42
6.6;References;43
7;Chapter 3. Airway Glandular Development and Stem Cells;46
7.1;I. Introduction and Scope;47
7.2;II. Airway Submucosal Gland Structure/Function and Its Relationship to Human Diseases;48
7.3;III. Species-Specific Differences in Conducting Surface Airway Epithelial Cell Types and Submucosal Gland Abundance;50
7.4;IV. Evidence for Human Adult Proximal Airway Stem Cells Capable of Developing Submucosal Glands;54
7.5;V. Mouse Tracheal Injury Models Suggest Submucosal Gland Ducts Are a Niche for Proximal Airway Stem Cells;58
7.6;VI. Developmental Molecular Markers of Glandular Stem Cell Phenotypes;59
7.7;VII. Concluding Remarks and Future Challenges;64
7.8;Acknowledgments;65
7.9;References;65
8;Chapter 4. Gene Expression Studies in Lung Development and Lung Stem Cell Biology;70
8.1;I. Introduction;70
8.2;II. Verifying and Challenging Old Concepts;72
8.3;III. Establishing New Concepts;74
8.4;IV. A Model for Lung Alveogenesis;75
8.5;V. Development and Stem Cells;76
8.6;VI. Applying Developmental Transcriptional Modules to Adult Disease;78
8.7;VII. Lung Cancer;78
8.8;VIII. Conclusion;79
8.9;Acknowledgments;80
8.10;References;80
9;Chapter 5. Mechanisms and Regulation of Lung Vascular Development;86
9.1;I. Introduction;86
9.2;II. Overview of Pulmonary Vessel Formation;87
9.3;III. Regulation of Lung Vasculature Formation;90
9.4;IV. Epithelial–Mesenchymal Interactions during Lung Vascular Development;98
9.5;V. Specification of Arterio-Venous Identity;99
9.6;VI. Endothelial Stem Cells in Lung Regeneration and Repair;103
9.7;VII. Conclusions;104
9.8;Acknowledgments;105
9.9;References;105
10;Chapter 6. The Engineering of Tissues Using Progenitor Cells;114
10.1;I. The Parenchyma: An Interactive Cell Population;115
10.2;II. A Working Hypothesis for Understanding Parenchymal Cell Interaction and Response;116
10.3;III. The Epidermis;118
10.4;IV. The Liver;129
10.5;V. The Pancreas and Generation of Pancreatic Islets;138
10.6;VI. Conclusions and Future Directions;143
10.7;References;144
11;Chapter 7. Adult Bone Marrow-Derived Hemangioblasts, Endothelial Cell Progenitors, and EPCs;154
11.1;I. Introduction;155
11.2;II. Stem and Progenitor Cells;156
11.3;III. Embryonic Hemangioblasts;158
11.4;IV. Adult Angioblasts;161
11.5;V. Adult Hemangioblasts;165
11.6;VI. Physiological Significance of Bone Marrow-Derived Endothelium;167
11.7;VII. Endothelial Cell Progenitors;169
11.8;VIII. Mobilization;173
11.9;IX. Bone Marrow-Induced Functional Improvements in Ischemic Tissue;176
11.10;X. Are We Ready for Human Trials?;178
11.11;XI. Looking to the Future;180
11.12;Acknowledgments;181
11.13;References;181
12;Chapter 8. Synthetic Extracellular Matrices for Tissue Engineering and Regeneration;194
12.1;I. Introduction;195
12.2;II. Inductive and Cell Transplantation Strategies;200
12.3;III. Engineering Vascular Structures;204
12.4;IV. Bone Regeneration;209
12.5;V. Conclusions and Future Directions;212
12.6;Acknowledgments;213
12.7;References;213
13;Chapter 9. Integrins and Angiogenesis;220
13.1;I. Introduction;221
13.2;II. Endothelial Cell Integrins;222
13.3;III. Initiation of Angiogenesis;227
13.4;IV. Alterations in Integrin–ECM Interactions During Angiogenesis;231
13.5;V. Integrin Antagonists Effects versus the Phenotype of Knockout Animals;240
13.6;VI. Perspective and Conclusions;241
13.7;References;243
14;Index;252
15;Contents of Previous Volumes;262