Current Topics in Developmental Biology

1. Auflage 2006
ISBN: 978-0-08-046552-4
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band Volume 76, 304 Seiten, Web PDF

Reihe: Current Topics in Developmental Biology

Current Topics in Developmental Biology provides a comprehensive survey of the major topics in the field of developmental biology. These volumes are valuable to researchers in animal and plant development, as well as to students and professionals who want an introduction to cellular and molecular mechanisms of development. The series has recently passed its 30-year mark, making it the longest-running forum for contemporary issues in developmental biology. - Includes many descriptive figures - Topics covered include Wnt signaling, controlling regulatory networks, cartilage growth plates, and more - Latest volume in the series that covers seven reviews in 300 pages

Autoren/Hrsg.

Inhaltsverzeichnis

1;Cover Page;1
2;Contents;6
3;Contributors;10
4;Chapter 1: BMP Signaling in the Cartilage Growth Plate;12
4.1;I. Introduction;13
4.2;II. Signaling Pathways Regulating Chondrogenesis;16
4.3;III. Overview of the BMP Signaling Pathway;19
4.4;IV. Regulation of TGF-beta/BMP Signaling;21
4.5;V. Expression of TGF-beta Superfamily Members, Their Receptors, and Inhibitors in Precartilaginous and Cartilaginous Elements;25
4.6;VI. TGF-betas and BMPs in Chondrogenesis;27
4.7;VII. Downstream Effectors of BMP Signaling: Smads and p38;36
4.8;VIII. Interactions with Other Signaling Pathways;39
4.9;IX. Perspectives;43
4.10;Acknowledgments;46
4.11;References;46
5;Chapter 2: The CLIP-170 Orthologue Bik1p and Positioning the Mitotic Spindle in Yeast;60
5.1;I. Introduction;61
5.2;II. Structure of the Bik1 Protein;61
5.3;III. Bik1p Interactions with Other Proteins;71
5.4;IV. Phenotypes and Activities;72
5.5;V. Role of Bik1p in Spindle Positioning;74
5.6;VI. Models for Plus-End Binding;81
5.7;VII. Regulation of CLIP-170 and Bik1p by Phosphorylation;86
5.8;VIII. Bik1p at the Kinetochore;87
5.9;IX. Bik1p in Genomic Studies;87
5.10;X. Concluding Remarks and Perspective;89
5.11;Acknowledgments;90
5.12;References;90
6;Chapter 3: Aggregate-Prone Proteins Are Cleared from the Cytosol by Autophagy: Therapeutic Implications;100
6.1;I. Proteinopathies;101
6.2;II. Intracytoplasmic Aggregate-Prone Proteins Are Cleared by Autophagy;104
6.3;III. Autophagy Induction Has Additional Antiapoptotic Consequences;106
6.4;IV. A New mTOR-Independent Autophagy Pathway;106
6.5;V. A Protective Role for Aggregates: Autophagy Upregulation;108
6.6;VI. Conclusions;109
6.7;Acknowledgments;109
6.8;References;110
7;Chapter 4: Wnt Signaling: A Key Regulator of Bone Mass;114
7.1;I. Introduction;115
7.2;II. The Wnt Signaling Pathway;116
7.3;III. LRP5 and -6: Structure and Function;119
7.4;IV. Human Genetic Evidence for the Role of Wnt Signaling in Bone Metabolism;121
7.5;V. How Is the HBM Mutation Constitutively Activating LRP5 and Wnt Signaling?;122
7.6;VI. Mouse Genetics Confirms the Essential Role of the Wnt/beta-Catenin Pathway in Bone;123
7.7;VII. How Is Wnt Signaling Affecting Bone Homeostasis?;126
7.8;VIII. Effects of Wnts on Osteoblasts;127
7.9;IX. Is the Wnt Pathway the Final Common Pathway of Bone Morphogens?;128
7.10;X. Is Wnt Signaling the Pathway Linking Mechanosensing to Bone Remodeling?;130
7.11;XI. Pharmacological Manipulation of Wnt Signaling in Bone;131
7.12;XII. Conclusion and Perspectives;132
7.13;References;132
8;Chapter 5: Eukaryotic DNA Replication in a Chromatin Context;140
8.1;I. Chromatin Structure Regulates Access to the DNA;141
8.2;II. Replication Origins and Origin-Binding Proteins;148
8.3;III. Assembly of the Prereplication Complex on Chromatin;155
8.4;IV. Origin Activation and Replication;161
8.5;V. Replication Elongation Through Chromatin;165
8.6;VI. Conclusions;173
8.7;Acknowledgments;173
8.8;References;174
9;Chapter 6: The Regulatory Network Controlling the Proliferation-Meiotic Entry Decision in the Caenorhabditis elegans Germ Line;196
9.1;I. Introduction;197
9.2;II. Temporal and Spatial Pattern of Proliferation and Initiation of Meiotic Development;198
9.3;III. Summary of the Core Regulatory Pathway Controlling the Proliferation-Meiotic Development Decision;203
9.4;IV. Control of the Adult Pattern of Proliferation and Meiotic Entry;207
9.5;V. Regulation of the Activity of the GLD-1 and GLD-2 Pathways;211
9.6;VI. Additional Components and Pathways Regulating the Proliferation-Meiotic Entry Decision;217
9.7;VII. Conclusions;221
9.8;Acknowledgments;222
9.9;References;222
10;Chapter 7: Regulation of Angiogenesis by Hypoxia and Hypoxia-Inducible Factors;228
10.1;I. Introduction;229
10.2;II. Mechanisms of Angiogenesis;230
10.3;III. The Hypoxia-Inducible Factor Family;232
10.4;IV. The Role of HIF in Developmental Angiogenesis;239
10.5;V. The Role of HIF in Adult Tissues;242
10.6;VI. HIF and Ischemic Injury;243
10.7;VII. HIF and Cancer;245
10.8;VIII. Conclusions;251
10.9;Acknowledgments;252
10.10;References;252
11;Index;270
12;Contents of Previous Volumes;284