Crawley / Trost Applications of Transition Metal Catalysis in Drug Discovery and Development

An Industrial Perspective
1. Auflage 2012
ISBN: 978-1-118-30986-5
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 384 Seiten, E-Book

This book focuses on the drug discovery and developmentapplications of transition metal catalyzed processes, which canefficiently create preclinical and clinical drug candidates as wellas marketed drugs. The authors pay particular attention tothe challenges of transitioning academically-developed reactionsinto scalable industrial processes. Additionally, the book lays thegroundwork for how continued development of transition metalcatalyzed processes can deliver new drug candidates. This workprovides a unique perspective on the applications of transitionmetal catalysis in drug discovery and development - it is aguide, a historical prospective, a practical compendium, and asource of future direction for the field.

Autoren/Hrsg.

Crawley, Matthew L.

Trost, Barry M.

Inhaltsverzeichnis

Preface vii
Contributors ix
About the Authors xi
1 Transition Metal Catalysis in the Pharmaceutical Industry1
Carl A. Busacca, Daniel R. Fandrick, Jinhua J. Song, and ChrisH. Senanayake (Boehringer Ingelheim Pharmaceuticals)
2 Selected Applications of Transition Metal-CatalyzedCarbon-Carbon Cross-Coupling Reactions in the PharmaceuticalIndustry 25
Hong C. Shen (Roche)
3 Selected Applications of Pd- and Cu-CatalyzedCarbon-Heteroatom Cross-Coupling Reactions in thePharmaceutical Industry 97
Jingjun Yin (Merck)
4 Asymmetric Cross-Coupling Reactions 165
Vince Yeh (Novartis) and William A. Szabo (Consultant in DrugDevelopment)
5 Metathesis Reactions 215
Oliver R. Thiel (Amgen)
6 Transition Metal-Catalyzed Synthesis of Five- and Six-MemberedHeterocycles 257
Cheol K. Chung (Merck) and Matthew L. Crawley (Main LineHealth)
7 Oxidative Catalysis 277
Lamont Terrell (GlaxoSmithKline)
8 Industrial Asymmetric Hydrogenation 315
Hans-Ulrich Blaser (Solvias)
Index 343

Über Autor(innen)

MATTHEW L. CRAWLEY, PhD, is the Director of the CommunityPhysician Electronic Medical Records Program at Main Line Health.Previously, he has worked as a medicinal chemist at Pfizer andWyeth Research. Dr. Crawley is an author of more than twentypublications, and his discoveries have resulted in severalpatents.
BARRY M. TROST, PhD, is Tamaki Professor of Humanitiesand Sciences in the Department of Chemistry at Stanford University.Dr. Trost has been elected a Fellow of the American Academy ofSciences and member of the National Academy of Sciences. He hasserved as chairman of the NIH Medicinal Chemistry Study Section,held over 120 university lectureships, and presented over 260plenary lectures at national and international meetings.