Coleman / Tsongalis Essential Concepts in Molecular Pathology

1. Auflage 2010
ISBN: 978-0-08-092218-8
Verlag: Elsevier Science & Techn.
Format: EPUB
Kopierschutz: 6 - ePub Watermark

E-Book, Englisch, 462 Seiten

This streamlined 'essential' version of the Molecular Pathology (2009) textbook extracts key information, illustrations and photographs from the main textbook in the same number and organization of chapters. It is aimed at teaching students in courses where the full textbook is not needed, but the concepts included are desirable (such as graduate students in allied health programs or undergraduates). It is also aimed at students who are enrolled in courses that primarily use a traditional pathology textbook, but need the complementary concepts of molecular pathology (such as medical students). Further, the textbook will be valuable for pathology residents and other postdoctoral fellows who desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school.
Offers an essential introduction to molecular genetics and the 'molecular' aspects of human diseaseTeaches from the perspective of 'integrative systems biology,' which encompasses the intersection of all molecular aspects of biology, as applied to understanding human diseaseIn-depth presentation of the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease using histopathology. 'Traditional' pathology section provides state-of-the-art information on the major forms of disease, their pathologies, and the molecular mechanisms that drive these diseases.Explains the practice of 'molecular medicine' and the translational aspects of molecular pathology: molecular diagnostics, molecular assessment, and personalized medicineStudent web site hosts 'self-assessment' questions; Professor web site hosts all figures from bookEach chapter ends with Key Summary Points and Suggested Readings

Autoren/Hrsg.

Coleman, William B.

Tsongalis, Hcld

Inhaltsverzeichnis

1;Front Cover;1
2;Essential Concepts in Molecular Pathology;4
3;Copyright Page;5
4;Dedication;6
5;Contents;8
6;List of Contributors;14
7;Preface;18
8;Foreword;20
9;Acknowledgements;22
10;Part I: Essential Pathology - Mechanisms of Disease;24
10.1;Chapter 1: Molecular Mechanisms of Cell Death;26
10.1.1;Introduction;26
10.1.2;Modes of Cell Death;26
10.1.3;Structural Features of Necrosis and Apoptosis;26
10.1.4;Cellular and Molecular Mechanisms Underlying Necrotic Cell Death;28
10.1.5;Pathways to Apoptosis;31
10.1.6;Mitochondria;33
10.1.7;Nucleus;35
10.1.8;Endoplasmic Reticulum;35
10.1.9;Lysosomes;36
10.1.10;Concluding Remark;36
10.1.11;Acknowledgments;36
10.1.12;Key Concepts;36
10.1.13;Suggested Readings;37
10.2;Chapter 2: Acute and Chronic Inflammation Induces Disease Pathogenesis;38
10.2.1;Introduction;38
10.2.2;Leukocyte Adhesion, Migration, and Activation;38
10.2.3;Acute Inflammation and Disease Pathogenesis;40
10.2.4;Pattern Recognition Receptors and Inflammatory Responses;41
10.2.5;Chronic Inflammation and Acquired Immune Responses;43
10.2.6;Tissue Remodeling During Acute and Chronic Inflammatory Disease;45
10.2.7;Key Concepts;47
10.2.8;Suggested Readings;47
10.3;Chapter 3: Infection and Host Response;48
10.3.1;Microbes and Hosts-Balance of Power?;48
10.3.2;The Structure of the Immune Response;48
10.3.3;Regulation of Immunity;49
10.3.4;Pathogen Strategies;49
10.3.5;The African Trypanosome and Antibody Diversity: Dueling Genomes;50
10.3.6;Staphylococcus Aureus: the Extracellular Battleground;52
10.3.7;Mycobacterium Tuberculosis and the Macrophage;57
10.3.8;Herpes Simplex Virus: Taking Over;59
10.3.9;HIV: The Immune Guerilla;61
10.3.10;Perspectives;65
10.3.11;Key concepts;65
10.3.12;Suggested Readings;65
10.4;Chapter 4: Neoplasia;68
10.4.1;Introduction;68
10.4.2;Cancer Statistics and Epidemiology;68
10.4.3;Classification of Neoplastic Diseases;73
10.4.4;Characteristics of Benign and Malignant Neoplasms;79
10.4.5;Clinical Aspects of Neoplasia;82
10.4.6;Key Concepts;83
10.4.7;Suggested Readings;84
11;Part II: Concepts in Molecular Biology and Genetics;86
11.1;Chapter 5: Basic Concepts in Human Molecular Genetics;88
11.1.1;Introduction;88
11.1.2;Molecular Structure of DNA;88
11.1.3;Modes of Inheritance;89
11.1.4;Central Dogma and Rationale for Genetic Testing;94
11.1.5;Allelic Heterogeneity and Choice of Analytical Methodology;97
11.1.6;Conclusion;98
11.1.7;Key Concepts;99
11.1.8;Suggested Readings;99
11.2;Chapter 6: The Human Genome: Implications for the Understanding of Human Disease;100
11.2.1;Introduction;100
11.2.2;Structure and Organization of the Human Genome;100
11.2.3;Overview of the Human Genome Project;102
11.2.4;Impact of the Human Genome Project on the Identification Of Disease-Related Genes;104
11.2.5;Sources of Variation in the Human Genome;106
11.2.6;Types of Genetic Diseases;106
11.2.7;Genetic Diseases and Cancer;107
11.2.8;Perspectives;109
11.2.9;Key Concepts;109
11.2.10;Suggested Readings;110
11.3;Chapter 7: The Human Transcriptome: Implications for the Understanding of Human Disease;112
11.3.1;Introduction;112
11.3.2;Gene Expression Profiling: The Search for Candidate Genes Involved in Pathogenesis;112
11.3.3;Transcriptome Analysis Based on Microarrays: Technical Prerequisites;114
11.3.4;Microarrays: Applications in Basic Research and Translational Medicine;115
11.3.5;Perspectives;124
11.3.6;Key concepts;124
11.3.7;Suggested readings;126
11.4;Chapter 8: The Human Epigenome: Implications for the Understanding of Human Disease;128
11.4.1;Introduction;128
11.4.2;Epigenetic Regulation of the Genome;128
11.4.3;Genomic Imprinting;129
11.4.4;Cancer Epigenetics;131
11.4.5;Human Disorders Associated with Epigenetics;133
11.4.6;Key Concepts;135
11.4.7;Suggested Readings;135
11.5;Chapter 9: Clinical Proteomics and Molecular Pathology;136
11.5.1;Understanding Cancer at the Molecular Level: An Evolving Frontier;136
11.5.2;Microdissection Technology Brings Molecular Analysis to the Tissue Level;136
11.5.3;Serum Proteomics: an Emerging Landscape for Early Stage Cancer Detection;141
11.5.4;Key concepts;145
11.5.5;Suggested Readings;145
11.6;Chapter 10: Integrative Systems Biology: Implications for the Understanding of Human Disease;148
11.6.1;Introduction;148
11.6.2;Data Generation;149
11.6.3;Data Integration;151
11.6.4;Modeling Systems;152
11.6.5;Implications for Understanding Disease;153
11.6.6;Discussion;155
11.6.7;Key Concepts;156
11.6.8;Suggested Readings;156
12;Part III: Principles and Practice of Molecular Pathology;158
12.1;Chapter 11: Pathology: The Clinical Description of Human Disease;160
12.1.1;Current Practice of Pathology;160
12.1.2;The Future of Diagnostic Pathology;163
12.1.3;Conclusion;164
12.1.4;Key Concepts;164
12.1.5;Suggested Readings;164
12.2;Chapter 12: Understanding Molecular Pathogenesis: The Biological Basis of Human Disease and Implications for Improved Treatment of Human Disease;166
12.2.1;Introduction;166
12.2.2;Hepatitis C Virus Infection;166
12.2.3;Acute Myeloid Leukemia;169
12.2.4;Cystic Fibrosis;171
12.2.5;Key Concepts;174
12.2.6;Suggested Readings;174
12.3;Chapter 13: Integration of Molecular and Cellular Pathogenesis: A Bioinformatics Approach;176
12.3.1;Introduction;176
12.3.2;Overview of Bioinformatics;177
12.3.3;Database Resources;178
12.3.4;Data Analysis;179
12.3.5;The Future;180
12.3.6;Key Concepts;181
12.3.7;Suggested Readings;181
13;Part IV: Molecular Pathology of Human Disease;182
13.1;Chapter 14: Molecular Basis of Cardiovascular Disease;184
13.1.1;General Molecular Principles of Cardiovascular Diseases;184
13.1.2;The Cells of Cardiovascular Organs;184
13.1.3;Atherosclerosis;187
13.1.4;Ischemic Heart Disease;190
13.1.5;Aneurysms;190
13.1.6;Valvular Heart Disease;191
13.1.7;Cardiomyopathies;192
13.1.8;Key Concepts;196
13.1.9;Suggested Readings;196
13.2;Chapter 15: Molecular Basis of Hemostatic and Thrombotic Diseases;198
13.2.1;Introduction and Overview of Coagulation;198
13.2.2;Disorders of Soluble Clotting Factors;200
13.2.3;Disorders of Platelet Number or Function;205
13.2.4;Thrombophilia;208
13.2.5;Key concepts;210
13.2.6;Suggested Readings;210
13.3;Chapter 16: Molecular Basis of Lymphoid and Myeloid Diseases;212
13.3.1;Development of the Blood and Lymphoid Organs;212
13.3.2;Myeloid Disorders;216
13.3.3;Lymphocyte Disorders;221
13.3.4;Key concepts;225
13.3.5;Suggested Readings;225
13.4;Chapter 17: Molecular Basis of Diseases of Immunity;228
13.4.1;Introduction;228
13.4.2;Normal Immune System;228
13.4.3;Major Syndromes;231
13.4.4;Key Concepts;238
13.4.5;Suggested Readings;238
13.5;Chapter 18: Molecular Basis of Pulmonary Disease;240
13.5.1;Introduction;240
13.5.2;Neoplastic lung and pleural diseases;240
13.5.3;Obstructive Lung Diseases;251
13.5.4;Interstitial Lung Diseases;258
13.5.5;Pulmonary Vascular Diseases;261
13.5.6;Developmental Abnormalities;263
13.5.7;Key Concepts;265
13.5.8;Suggested Readings;265
13.6;Chapter 19: Molecular Basis of Diseases of the Gastrointestinal Tract;266
13.6.1;Gastric Cancer;266
13.6.2;Colorectal Cancer;271
13.6.3;Key Concepts;283
13.6.4;Suggested Readings;284
13.7;Chapter 20: Molecular Basis of Liver Disease;286
13.7.1;Introduction;286
13.7.2;Molecular Basis of Liver Development;286
13.7.3;Molecular Basis of Liver Regeneration;288
13.7.4;Adult Liver Stem Cells in Liver Health and Disease;289
13.7.5;Molecular Basis of Hepatocyte Death;290
13.7.6;Molecular Basis of Nonalcoholic Fatty Liver Disease;291
13.7.7;Molecular Basis of Alcoholic Liver Disease;294
13.7.8;Molecular Basis of Hepatic Fibrosis and Cirrhosis;295
13.7.9;Molecular Basis of Hepatic Tumors;297
13.7.10;Key Concepts;300
13.7.11;Suggested Readings;300
13.8;Chapter 21: Molecular Basis of Diseases of the Exocrine Pancreas;302
13.8.1;Acute Pancreatitis;302
13.8.2;Chronic and Hereditary Pancreatitis;307
13.8.3;Key concepts;310
13.8.4;Suggested readings;311
13.9;Chapter 22: Molecular Basis of Diseases of the Endocrine System;312
13.9.1;Introduction;312
13.9.2;The Pituitary Gland;312
13.9.3;The Thyroid Gland;315
13.9.4;Familial Nonautoimmune Hyperthyroidism;318
13.9.5;The Parathyroid Gland;319
13.9.6;The Adrenal Gland;322
13.9.7;Puberty;325
13.9.8;Key Concepts;329
13.9.9;Suggested Readings;329
13.10;Chapter 23: Molecular Basis of Gynecologic Diseases;332
13.10.1;Introduction;332
13.10.2;Benign and Malignant Tumors of the Female Reproductive Tract;332
13.10.3;Disorders Related to Pregnancy;342
13.10.4;Key Concepts;344
13.10.5;Suggested Readings;345
13.11;Chapter 24: Molecular Pathogenesis of Diseases of the Kidney;346
13.11.1;Introduction;346
13.11.2;Normal Kidney Function;346
13.11.3;Focal Segmental Glomerulosclerosis;346
13.11.4;Fabry Disease;348
13.11.5;Polycystic Kidney Disease;350
13.11.6;Disorders of Renal Tubular Function;353
13.11.7;Key Concepts;355
13.11.8;Suggested Readings;355
13.12;Chapter 25: Molecular Pathogenesis of Prostate Cancer: Somatic, Epigenetic, and Genetic Alterations;358
13.12.1;Introduction;358
13.12.2;Hereditary Component of Prostate Cancer Risk;359
13.12.3;Somatic Alterations in Gene Expression;359
13.12.4;Epigenetics;361
13.12.5;Conclusion;362
13.12.6;Acknowledgments;362
13.12.7;Key Concepts;363
13.12.8;Suggested Readings;363
13.13;Chapter 26: Molecular Biology of Breast Cancer;364
13.13.1;Introduction;364
13.13.2;Traditional Breast Cancer Classification;364
13.13.3;Biomarkers;366
13.13.4;Gene Expression Profiling;369
13.13.5;Conclusion;371
13.13.6;Key Concepts;371
13.13.7;Suggested Readings;371
13.14;Chapter 27: Molecular Basis of Skin Disease;374
13.14.1;Molecular basis of healthy skin;374
13.14.2;Skin development and maintenance provide new insight into molecular mechanisms of disease;375
13.14.3;Molecular pathology of Mendelian genetic skin disorders;377
13.14.4;Molecular pathology of common inflammatory skin diseases;382
13.14.5;Skin proteins as targets for inherited and acquired disorders;384
13.14.6;Molecular pathology of skin cancer;387
13.14.7;Molecular diagnosis of skin disease;391
13.14.8;New molecular mechanisms and novel therapies;393
13.14.9;Key concepts;395
13.14.10;Suggested Readings;395
13.15;Chapter 28: Molecular Pathology: Neuropathology;396
13.15.1;Anatomy of the Central Nervous System;396
13.15.2;Neurodevelopmental Disorders;399
13.15.3;Neurological Injury: Stroke, Neurodegeneration, and Toxicants;403
13.15.4;Neoplasia;413
13.15.5;Disorders of Myelin;417
13.15.6;Key Concepts;420
13.15.7;Suggested Readings;420
14;Part V: Practice of Molecular Medicine;422
14.1;Chapter 29: Molecular Diagnosis of Human Disease;424
14.1.1;Introduction;424
14.1.2;History of Molecular Diagnostics;424
14.1.3;Molecular Laboratory Subspecialties;426
14.1.4;Key Concepts;434
14.1.5;Suggested Readings;434
14.2;Chapter 30: Molecular Assessment of Human Disease in the Clinical Laboratory;436
14.2.1;Introduction;436
14.2.2;The Current Molecular Infectious Disease Paradigm;437
14.2.3;A New Paradigm for Molecular Diagnostic Applications;438
14.2.4;BCR-ABL: A Model for the New Paradigm;441
14.2.5;Conclusion;443
14.2.6;Key Concepts;443
14.2.7;Suggested Readings;443
14.3;Chapter 31: Pharmacogenomics and Personalized Medicine in the Treatment of Human Diseases;444
14.3.1;Introduction;444
14.3.2;Conclusion;451
14.3.3;Key Concepts;451
14.3.4;Suggested Readings;451
15;Index;452