New Strategies for N-Heterocyclic Carbenes Catalyzed Annulations

Softcover Nachdruck of the Original 1. 2017 Auflage 2018
ISBN: 978-981-10-9734-8
Verlag: Springer Nature Singapore

Buch, Englisch, 123 Seiten, Previously published in hardcover, Format (B × H): 156 mm x 234 mm, Gewicht: 204 g

Reihe: Springer Theses

This thesis focuses on NHC-catalyzed annulation of nitroalkenes, enals and a,ß-unsaturated carboxylic acids. (1) NHCs were found to be efficient catalysts for the [4+2] annulation of ß-substituted nitroalkenes. The scope of Rauhut–Currier reaction was successfully extended to the most challenging ß-substituted alkenes by this method; (2) Enals were successfully used for [4+2] annulations with azodicarboxylates catalyzed by NHC via ?-addition. Highly enantiopure tetrahydropyridazinones and ?-amino acid derivatives could be easily prepared by subsequent transformations of the resulting dihydropyridazinones. (4) The readily available a,ß-unsaturated carboxylic acids were first successfully employed to generate the a,ß-unsaturated acyl azolium intermediates by using NHC for the enantioselective [3+2] and [3+3] annulations.

Zielgruppe

Research

Autoren/Hrsg.

Chen, Xiangyu

Fachgebiete

• Naturwissenschaften Chemie Organische Chemie
• Naturwissenschaften Chemie Physikalische Chemie Chemische Reaktionen, Katalyse
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie

Inhaltsverzeichnis

Introduction.- NHC-catalyzed Annulations of Nitroalkenes.- NHC-catalyzed Enantioselective Annulations of Enals.- NHC-catalyzed Enantioselective Annulations of a,ß-unsaturated Carboxylic Acids.- Experimental Part.- Research Summary.