Organic Synthesis with Enzymes in Non-Aqueous Media

1. Auflage 2008
ISBN: 978-3-527-31846-9
Verlag: WILEY-VCH

Buch, Englisch, 310 Seiten, Format (B × H): 170 mm x 240 mm, Gewicht: 782 g

Closing a gap in the literature, this comprehensive book examines and discusses different non-aqueous systems from organic solvents to ionic liquids for synthetic applications, thus opening the door to new successful methods for biocatalytic reactions. It gathers into one handy source the information otherwise widely spread throughout the literature, combining useful background information with a number of synthetic examples, including industrial scale processes for pharmaceutical and fine chemicals.
Extremely well structured, the text introduces the fundamentals of non-aqueous enzymology, before going on to new reaction media and synthetic applications using hydrolases and non-hydrolytic enzymes.
The one-stop reference for everyone working in this hot field.

Autoren/Hrsg.

Carrea, Giacomo

Riva, Sergio

Fachgebiete

• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Naturwissenschaften Chemie Organische Chemie Supramolekularchemie
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie Industrielle Biotechnologie

Inhaltsverzeichnis

Introduction (G. Carrea and S. Riva)
PART I: BIOCATALYSIS IN NEAT ORGANIC SOLVENTS - FUNDAMENTALS
Fundamentals of biocatalysis in neat organic solvents (Patrick Adlercreutz)
Effects of organic solvents on enzyme selectivity (Jaap Jongejan)
Activating enzymes for use in organic solvents (Anne Serdakowski and Jonathan Dordick)
PART II: BIOCATALYSIS IN NEAT ORGANIC SOLVENTS - SYNTHETIC APPLICATIONS
Exploiting enantioselectivity of hydrolases in organic solvents (Hans-Erik Hogberg)
Enzymatic dynamic kinetic resolution processes (Jan Backvall)
Exploiting enzyme regioselectivity and chemoselectivity (Sergio Riva)
Industrial scale applications of enzymes in non aqueous solvents (David Pollard and Birgit Kosjek)
PART III: BIOCATALYSIS IN BIPHASIC AND NEW REACTION MEDIA
Biocatalysis in biphasic systems: general (Pedro Fernandes and Joaquim Cabral)
Biocatalysis in biphasic systems: oxynitrilases (Manuela Avi and Herfried Griengl
Ionic liquids as media for enzymatic transformations (Roger Sheldon and Fred van Rantwijk)
Solid/gas biocatalysis (Isabelle Goubet, Marianne Graber, Sylvain Lamare, Thierry Maugard and Marie-Dominique Legoy)
Biocatalysis with undissolved solid substrates and products (Alessandra Basso, Sara Cantone, Cynthia Ebert, Peter Halling and Lucia Gardossi)

Über Autor(innen)

Dr. Giacomo Carrea joined the Italian National Research Council (CNR) in 1969 where presently he is Director of the Institute of Chemistry of Molecular Recognition. He has been working in such fields as enzyme catalysis in organic solvents, synthesis of fine chemicals catalyzed by hydrolases, dehydrogenases, peroxidases and monooxygenases, study of conformation of proteins and polypeptides and analytical applications of bioluminescent enzymes. He is a member of the Editorial Board of "Trends in Biotechnology" and "Biocatalysis and Biotransformation" and the author of about 220 publications in international peer reviewed journals.
 
Dr. Sergio Riva is a Senior Research Scientist at the Institute of the Chemistry of Molecular Recognition. He took his Laurea in Chemistry in 1983 and his Diploma di Specialita? in Organic Synthesis in 1989. In 1987 he was at M.I.T. (USA) working with Prof. A. Klibanov. In 1993 he was awarded the Ciamician medal by the Organic Chemical Division of the Italian Chemical Society for his research activity in biocatalysis, presently documented by more than 150 publications reporting on the isolation and characterization of enzymes and on the synthetic exploitation of these biocatalysts.