Regulation of Gene Expression in Animal Viruses

Softcover Nachdruck of the original 1. Auflage 1993
ISBN: 978-1-4613-6271-5
Verlag: Springer US

Buch, Englisch, Band 240, 325 Seiten, Paperback, Format (B × H): 170 mm x 244 mm, Gewicht: 581 g

Reihe: NATO Science Series A:

Viruses, being obligatory parasites of their host cells, rely on a vast supply of cellular components for their replication, regardless of whether infection leads to cell death or to the state of persistence. Animal viruses are providing scientists with relatively simple models to study the molecular biology of genome replication and gene expression. Whereas viruses use, in general, pathways of macromolecular biosynthesis common to the host cell, they have a cunning ability to adopt unusual mechanisms of gene expression and gene replication, provided these special pathways offer an advantage in competition for cellular resources. Any study of viral gene expression and replication is likely to lead also to new insights in cellular metabolism. The discoveries of cis-acting regulatory elements in transcription, the phenomenon of splicing of pre­ mRNA, and cap-dependent and cap-independent initiation of translation may be cited as examples. In addition, animal virus genomes contain elements and encode proteins that are very useful for the design of vectors for gene cloning and expression in mammalian cells. Apart from the basic interest in their biology, viruses have gained notoriety, of course, because they are pathogens. Human animal viruses may cause diseases ranging from the deadly (AIDS) to the benign (common cold). All studies on animal viruses potentially lead to the development of tools for their control, be it through prevention by immunization or treatment with antiviral drugs. Finally, viruses have yielded invaluable reagents in molecular biology as, for example, the vaccinia virus vector for the expression of foreign genes.

Zielgruppe

Research

Autoren/Hrsg.

Carrasco, Luis

Wimmer, Eckard

Sonenberg, Nahum

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften Ökologie
• Naturwissenschaften Biowissenschaften Tierkunde / Zoologie
• Naturwissenschaften Biowissenschaften Mikrobiologie
• Naturwissenschaften Biowissenschaften Zellbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik
• Naturwissenschaften Biowissenschaften Botanik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Medizinische Mikrobiologie & Virologie

Inhaltsverzeichnis

Structure of a human rhinovirus complexed with its receptor molecule.- Cascade regulation of vaccinia virus gene expression.- Regulation of alpha and gamma gene expression in cells infected with herpes simplex viruses.- Transcriptional activation by the adenovirus E1A proteins.- Mechanisms regulating nucleocapsid formation of the hepatitis B viruses.- Transcriptional activation by the hepatitis B virus X protein.- Regulation of human immunodeficiency virus structural protein expression and virion formation.- Transcription factors of the ETS family: The example of C-ETS1.- Infectious influenza viruses from cDNA-derived RNA: reverse genetics.- Structure and function of the vesicular stomatitis virus RNA-dependent RNA polymerase.- RNA Synthesis and mRNA Editing in Paramyxovirus Infections.- Antigenic variation of human respiratory syncytial virus G Glycoprotein: Genetic mechanisms and evolutionary significance.- Translation regulation by reovirus structural proteins.- The regulation of Coronavirus gene expression.- Interaction of initiation factors and capsid protein with the cap structure of chimaeric MRNAS containing the 5? untranslated regions of the RNAS of semliki forest virus.- Aspects of the molecular biology of poliovirus replication.- 3CD Cleavage of the poliovirus P1 precursor: a model for complex proteinase/substrate interactions.- Studies on the mechanism of internal initiation of translation on poliovirus RNA.- Picornavirus Variation.- Modification of membrane permeability by animal viruses.- Miguel Angel Sanz and Ma José Ayala, Poliovirus neurovirulence and its attenuation.