Carlton Pharmaceutical Microscopy

1. Auflage 2011
ISBN: 978-1-4419-8831-7
Verlag: Springer US
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 321 Seiten, eBook

Microscopy plays an integral role in the research and development of new medicines. Pharmaceutical Microscopy describes a wide variety of  techniques together with numerous practical  applications of importance in drug development. The first section  presents general methods and applications with an emphasis on the physical science aspects. Techniques covered include optical crystallography, thermal microscopy, scanning electron microscopy, energy dispersive x-ray spectrometry, microspectroscopy (infrared and Raman), and particle size and shape by image analysis. The second section presents applications of these techniques to specific topics of pharmaceutical interest, including studies of polymorphism, particle size and shape analysis, and contaminant identification.  Pharmaceutical Microscopy is designed for those scientists who must use these techniques to solve pharmaceutical problems but do not need to become expert microscopists.  Consequently, eachsection has exercises designed to teach the reader how to use and apply the techniques in the book.  Although the focus is on pharmaceutical development, workers in other fields such as food science and organic chemistry will also benefit from the discussion of techniques and the exercises.Provides comprehensive coverage of key microscopy techniques used in pharmaceutical development Helps the reader to solve specific problems in pharmaceutical quality assuranceOriented and designed for pharmaceutical scientists who need to use microscopy but are not expert microscopistsIncludes a large number of practical exercises to give the reader hands-on experience with the techniquesWritten by an author with 21 years of experience in the pharmaceutical industry

Zielgruppe

Research

Autoren/Hrsg.

Carlton, Robert Allen

Inhaltsverzeichnis

Chapter 1: Introduction.- METHODS AND TECHNIQUESChapter 2: Polarized Light Microscopy: Theory of PLM.- Polarized Light.- Optical Crystallography.- Types of Instruments.- Köhler Illumination.- Chapter 3: Thermal Microscopy.- Introduction.- Instruments and Methods.- Calibration.- Observations.- Exercises.- Chapter 4: SEM and EDS: Scanning Electron Microscopy.- Energy Dispersive X-ray Spectrometry.- Exercises.- Chapter  5: Microspectroscopy: Theory.- Infrared Microspectroscopy.- Raman Microspectroscopy.- Chemical Imaging.- Exercises.- Chapter 6: Other Types of Microscopy: Confocal Microscopy.- Atomic Force Microscopy.- Transmission Electron Microscopy.- DIC.- Phase contrast.- Dispersion staining.- Flourescence.- Freeze dry microscopy.- Chapter 7: Image Analysis: Digital Image Analysis.- Statistical Analysis.- Exercises (using ImageJ or Joys program).- APPLICATIONSChapter 8: Polymorphism: Theory.- Early Stage Development Studies.- Late Stage Development Studies.- Exercises.- Chapter 9: Size and Shape Analysis: Theory.- Sampling.- Comparison with other Techniques.- Automation.- Validation.- Exercises.- Chapter 10: Contaminant Analysis: General Approach.- Examples.- Exercises.- Chapter 11: Conclusion.- Chapter 12: References and Bibliography.-