Multimodal Concepts for Integration of Cytotoxic Drugs

2006
ISBN: 978-3-540-25655-7
Verlag: Springer Berlin Heidelberg

Buch, Englisch, 352 Seiten, HC runder Rücken kaschiert, Format (B × H): 195 mm x 276 mm, Gewicht: 1093 g

Reihe: Radiation Oncology

The first part of this book summarizes the rationale and the preclinical data for combined treatment with ionizing radiation and pharmaceutical agents. Individual chapters focus on forms of combined treatment, with due consideration being given to a range of drugs and to emerging combinations with small molecules and antibodies. The second part comprises a series of disease-specific chapters in which the clinical results of combined modality treatment are presented.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Brown, Martin J.

Mehta, M. P.

Nieder, Carsten

Weitere Mitwirkende

Brady, L.W.

Heilmann, H.-P.

Molls, M.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Chirurgie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Pneumologie, Atmung, Asthma
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Bildgebende Verfahren, Nuklearmedizin, Strahlentherapie Nuklearmedizin, PET, Radiotherapie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Bildgebende Verfahren, Nuklearmedizin, Strahlentherapie Radiologie, Bildgebende Verfahren

Inhaltsverzeichnis

Preclinical Part.- Biological Basis of Combined Radio- and Chemotherapy.- Combinations of Antimetabolites and Ionizing Radiation.- Combinations of Taxanes and Ionizing Radiation.- Combinations of Topoisomerase Inhibitors and Ionizing Radiation.- Combinations of Hypoxia-Targeting Compounds and Radiation-Activated Prodrugs with Ionizing Radiation.- Combinations of Platinum Compounds and Ionizing Radiation.- Combinations of Cytotoxic Drugs, Ionizing Radiation, and Angiogenesis Inhibitors.- Combinations of Cytotoxic Drugs, Ionizing Radiation and EGFR Inhibitors.- Combinations of Cytotoxic Drugs, Ionizing Radiation, and Mammalian Target of Rapamycin (mTOR) Inhibitors.- Combinations of Ionizing Radiation and Other Sensitizing Agents.- Radiotherapy and Tumor-Targeted Drug Delivery.- Clinical Part.- Applications in Malignant Brain Tumors.- Applications in Head and Neck Cancer.- Applications in Esophageal and Gastric Cancer.- Novel Chemoradiation in Localized Pancreatic Cancer: Clinical Studies.- Applications in Lung Cancer.- Integration of Radiation Therapy and Systemic Therapy for Breast Cancer.- Applications in Rectal and Anal Cancer.- Concomitant Radiation and Chemotherapy in Muscle-Invasive Bladder Cancer.- Applications to Gynecological Cancers.- Early and Late Treatment-Induced Toxicity.- Feasibility of Combined Chemo- and Radiation Treatment in Elderly/Comorbid Patients.

Über Autor(innen)

J. Martin Brown, PhD, is a Professor of Radiation Oncology at Stanford University. He was president of the Radiation Research Society and member of several program and award committees of the American Association for Cancer Research. Dr. Brown is currently the senior editor for biology for the International Journal of Radiation Oncology Biology Physics. He has received a number of awards, including an NIH M.E.R.I.T. Award, the Research Award from the Radiation Research Society, the 1999 Cain Memorial Award from the American Association for Cancer Research, the 1999 ASTRO Gold Medal, and the Weiss Medal from the Association for Radiation Research. Minesh P. Mehta, MD, is Professor and Chairman of the Department of Human Oncology, University of Wisconsin Medical School, Madison. He is the Chairman of the Radiation Therapy Oncology Group Brain Tumor Committee and is on the editorial board of the Journal of Neuro-Oncology and the International Journal of Cancer Research.Carsten Nieder, MD, is head of the Radiation Oncology Section of the Multidisciplinary Cancer Center and deputy head of the Stereotactic Central Nervous System Radiotherapy program, Klinikum rechts der Isar, Munich. He has received a 2-year research scholarship from the Mildred Scheel Foundation and the Hanns Langendorff Award 2003. Dr. Nieder is on the editorial board of Reviews of Recent Randomized Trials.