Chemistry and Pharmacology of Naturally Occurring Bioactive Compounds

1. Auflage 2013
ISBN: 978-1-4398-9167-4
Verlag: CRC Press

Buch, Englisch, 584 Seiten, Format (B × H): 183 mm x 260 mm, Gewicht: 1282 g

Natural products play crucial roles in modern drug development, and constitute a prolific source of novel lead compounds or pharmacophores for ongoing drug discovery programs. Chemistry and Pharmacology of Naturally Occurring Bioactive Compounds presents cutting-edge research in the chemistry of bioactive natural products and demonstrates how natural product research continues to make significant contributions in the discovery and development of new medicinal entities.

In 21 chapters, this book highlights chemistry and pharmaceutical potential of natural products in modern drug discovery processes, and covers the synthesis and semi-synthesis of potentially bioactive natural products. Written for phytochemists, synthetic chemists, combinatorial chemists, as well as other practitioners and students in related fields, the book features chemical advances in naturally occurring organic compounds and describes their chemical transformations and structure–activity relationships.

Zielgruppe

Phytochemists, Synthetic chemists, Combinatorial Chemists, Phannacologists, Organic Chemists, Medicinal Chemists and Phannacologists, and students in related fields.

Autoren/Hrsg.

Brahmachari, Goutam

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
• Naturwissenschaften Chemie Organische Chemie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie

Inhaltsverzeichnis

Chemistry and Pharmacology of Naturally Occurring Bioactive Compounds: An Overview. Impact of Solid Supported Cyclization-Elimination Strategies towards the Development of Natural Product Inspired Molecules in Drug Discovery Research. Synthesis and Biological Studies of Novel b -Lactams. Applications of Isatin Chemistry in Organic Synthesis and Medicinal Chemistry. Role of Organic Carbamates in Anticancer Drug Design. Rational Design of New Molecules of Biological Significance from Phenolic Constituents of Some Tropical Plants as Renewable Materials. Synthesis and Biological Activity of Promising Azole Marine Products: Largazole and Neopeltolide. Omega-3 (O-3) Polyunsaturated Fatty Acids. Structure and Biological Activity of Natural Melanin Pigments. Recent Acquisitions on Naturally Occurring Oxyprenylated Secondary Plant Metabolites. Role of Curcumin in Ameliorating Neuroinflammation and Neurodegeneration Associated with Alzheimer’s Disease. Plant Metabolites - Inhibitors of NO Production. X-Ray Structural Behavior of Some Significant Bioactive Steroids and Their Chemistry in Crystal Packing and Related Matters. The Three-Dimensional Structure of Xanthones. Gambogic acid — A Caged Prenylated Garcinia Xanthone: Potent Anticancer Agent of Pharmaceutical Promise. Neuroplasticity as a New Approach to the Pathophisiology of Depression and the Role of Antidepressants in Inhibiting Brain Stress-induced Changes. The Statins: Fermentation Products for Cholesterol Control in Humans. Molecular Aspects of Fungal Bioactive Polyketides. Marine Micro-Algal Metabolites: A Promising Source of Pharmaceuticals. Rosmarinic acid: Biological, Pharmacological and in vitro Plant Cell Culture Approximation. Enhancement of Natural Antioxidants in Plants by Biosynthetic Pathway Modulation. Plant as Biofactories of Pharmaceuticals and Nutraceuticals. Index.

Über Autor(innen)

Goutam Brahmachari, Ph.D. is an Associate Professor within the Laboratory of Natural Products and Organic Synthesis, Department of Chemistry, at Visva-Bharati University, India.