Bradley / Harris / Jenner The Neuromodulators

1. Auflage 2005
ISBN: 978-0-08-046076-5
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band Volume 64, 296 Seiten, Web PDF

Reihe: International Review of Neurobiology

Glutamate and GABA are the main information carrying neurotransmitters in the brain. Their action is modulated by a further series of small molecules called neuromodulators. The major neuromodulators in the brain are acetylcholine (both muscarinic and nicotinic), dopamine, norepinephrine, epinephrine and serotonin. These have an enormous range of functions in a wide variety of brain mechanisms. This book attempts to give a general overview of this field with a section devoted to each of these. Each section starts with anatomy, both structural and functional. The various types of receptors for these agents are described and then the effects of stimulating these receptors. These receptors trigger a variety of electrical reactions that generally involve potassium, sodium or calcium channels. Also reviewed are other receptors that trigger a wide variety of post-synaptic signaling cascades that influence a large number of neuronal functions including receptor sensitivity, synaptic plasticity and gene manipulation. Finally the relevance of these systems to disease states is detailed. There are many reviews of individual neuromodulators but this is the only book where one author attempts to cover the whole field.

Autoren/Hrsg.

Jenner, Peter

Bradley, Ronald J.

Harris, R. Adron

Smythies, John

Inhaltsverzeichnis

1;front cover;1
2;copyright;5
3;table of contents;6
4;Preface;8
5;SECTION I THE CHOLINERGIC SYSTEM;9
5.1;PART I. INTRODUCTION;11
5.1.1;I. Anatomy;11
5.2;PART II. THE MUSCARINIC SYSTEM;12
5.2.1;I. Anatomy;12
5.2.2;II. Electrical Activity;16
5.2.3;III. Interactions with Other Transmitters;27
5.2.4;IV. Postsynaptic Cascades;32
5.2.5;V. Other Topics;37
5.3;PART III. THE NICOTINIC SYSTEM;63
5.3.1;I. Microanatomy;63
5.3.2;II. Functional Microanatomy;66
5.3.3;III. Interactions with Other Transmitters;69
5.3.4;IV. Learning;80
5.3.5;V. Miscellaneous Topics;85
5.4;Section I References;88
5.5;Section I Further Reading;125
6;SECTION II THE DOPAMINE SYSTEM;131
6.1;Section II Further Reading;178
6.2;Section II References;163
6.3;IX. Miscellaneous Items;163
6.4;VIII. Parkinson’s Disease;161
6.5;VII. Dopamine and Behavior;158
6.6;VI. Dopamine and Learning;156
6.7;V. Miscellaneous Items;151
6.8;IV. Dopamine-Induced Signaling Cascades;147
6.9;III. Interaction between Dopamine and other Transmitters;140
6.10;II. Electrical Reactions;137
6.11;I. Anatomy;132
7;SECTION III THE NOREPINEPHRINE SYSTEM;181
7.1;Section III Further Reading;219
7.2;Section III References;206
7.3;VIII. Miscellaneous Items;204
7.4;VII. Memory and Learning (LTP);200
7.5;VI. Tropins and Cytokines;199
7.6;V. Postsynaptic Cascades;193
7.7;IV. Interactions with Other Transmitters;188
7.8;III. Electrical Activity;186
7.9;II. Functional Neuroanatomy;183
7.10;I. Microanatomy;182
8;SECTION IV THE ADRENALINE SYSTEM;220
8.1;Section IV References;221
9;SECTION V SEROTONIN SYSTEM;223
9.1;Section V Further Readings;273
9.2;Section V References;255
9.3;VIII. Miscellaneous;251
9.4;VII. Sleep;250
9.5;VI. Serotonin and the Development of Neural Systems;249
9.6;V. Serotonin and Synaptic Plasticity;244
9.7;IV. Postsynaptic Cascades;242
9.8;III. Interactions Between Serotonin and Other Neurotransmitter Systems;234
9.9;II. Electrical Actions;229
9.10;I. Anatomy;224
10;SECTION VI CONCLUSION;275
10.1;Section VI References;277
11;Possibly Obscure Acronyms for some Readers;278
12;index;279